{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:21:48Z","timestamp":1742962908378,"version":"3.40.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oncomfort","award":["Funding Oncomfort provided the VRD device"],"award-info":[{"award-number":["Funding Oncomfort provided the VRD device"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colonoscopy is associated with discomfort that requires intravenous sedation (IVS). The aim of this randomized controlled trial (RCT) was to explore the feasibility of virtual reality distraction (VRD) for colonoscopy using two primary endpoints: cecal intubation rate and the rate of rescue with IVS.<\/jats:p><jats:p>Patients scheduled for elective colonoscopy with IVS were randomized in a 2:1 ratio in favor of VRD, with rescue IVS by propofol if needed. VRD involved use of a device providing a visual and auditive experience similar to clinical hypnosis.<\/jats:p><jats:p>Ninety patients were included (VRD:60, IVS: 30). Cecal intubation rate was similar in both groups (92.8% for VRD vs 100% for IVS, P=0.3). The rate of rescue IVS in the VRD group was 63.6%. There was a decrease in median total dose of propofol per patient in the VRD group (1.15 mg\/kg for VRD and 4.41 mg\/kg for IVS, P &lt;0.001) and in the subgroup of VRD patients who received IVS rescue (3.17 mg\/kg for VRD and 4.41 mg\/kg for IVS, P=0.003). The median level of pain was higher and the median level of comfort was lower in the VRD group (respectively 3 vs 0, P &lt;0.001 and 7 vs 10, P &lt;0.001).<\/jats:p><jats:p>This RCT provides preliminary data to better understand the feasibility of VRD for colonoscopy. We have not identified differences in procedure outcomes compared with conventional IVS, but nevertheless, higher pain and lower comfort scores were reported.<\/jats:p>","DOI":"10.1055\/a-2520-9768","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:49:08Z","timestamp":1737420548000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Impact of virtual reality distraction during colonoscopy vs intravenous deep sedation: Results of a single-center randomized controlled trial"],"prefix":"10.1055","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct04465383","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Anastasia","family":"Pavlidi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Oncology and Hepatopancreatology, HUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, 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Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-0167","authenticated-orcid":false,"given":"Arnaud","family":"Lemmers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Oncology and Hepatopancreatology, HUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-574X","authenticated-orcid":false,"given":"Vincent","family":"Huberty","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Oncology and Hepatopancreatology, HUB H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Forget","sequence":"additional","affiliation":[{"name":"Anaesthesia, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Department of Anaesthesia, NHS Grampian, Aberdeen, United Kingdom, Aberdeen, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hannen","sequence":"additional","affiliation":[{"name":"Anaesthesia, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Department of Anaesthesia, NHS Grampian, Aberdeen, United Kingdom, Aberdeen, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Quolin","sequence":"additional","affiliation":[{"name":"European Organisation for Research and Treatment in Cancer (EORTC), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgay","family":"Tuna","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, HUB H\u00f4pital Erasme, Universit\u00e9 Libre de 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