{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:53:25Z","timestamp":1755219205860,"version":"3.43.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extra\u2013Intracranial (EC\u2013IC) bypass surgery is an effective procedure to restore hemodynamic insufficiency and mitigating cerebral ischemia. With increasing life expectancy, the incidence of patients with hemodynamic insufficiency is expected to rise further. Here we aimed to analyze the complications and patency rate of patients \u226570 years that underwent EC\u2013IC bypass and compare it with a younger cohort (&lt;70 years).<\/jats:p><jats:p>Patient charts were retrospectively reviewed for diagnosis, patient presentation, type of bypass, postoperative course, and follow-up. A total of 175 patients underwent arterial bypass during the study period. A total of 158 patients were &lt;70 years old compared with 17 patients \u226570 years old.<\/jats:p><jats:p>EC\u2013IC bypass was performed with a scalp artery in 88.2% cases in the older group and 88.0% cases in the younger group. The younger group was more likely to undergo bilateral bypass (28.1%) than the older group (0%; p\u2009=\u20090.01). There were no significant differences in overall medical and surgical complication rates between older and younger patients undergoing arterial bypass (p\u2009=\u20090.61). Direct postoperative graft patency was similar between groups. Follow-up patency data were available in 97.7% of patients (average 18.0\u2009\u00b1\u200925.1 months). Graft patency rate at follow-up was 88.3%, with rates 88.2% in the older group and 88.3% in the younger group.<\/jats:p><jats:p>Our data confirm previous data in the literature on the safety and efficacy of EC\u2013IC Bypass in the elderly population. These results suggest that variables other than age may be more important in determining potential benefit from EC\u2013IC bypass treatment.<\/jats:p>","DOI":"10.1055\/a-2521-3005","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:09:18Z","timestamp":1747336158000},"page":"459-466","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Complications and Patency Rates in Young and Elderly Patients Undergoing Extra\u2013Intracranial Bypass Surgery"],"prefix":"10.1055","volume":"86","author":[{"given":"Davide M.","family":"Croci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Farooq","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Monsour","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Vakharia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsz","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Mhaskar","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry van","family":"Loveren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siviero","family":"Agazzi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00701-012-1412-3","article-title":"STA-MCA bypass","volume":"154","author":"B A Gross","year":"2012","journal-title":"Acta Neurochir (Wien)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-7091-0661-7_10","article-title":"STA-MCA bypass for the treatment of ischemic stroke","volume":"112","author":"K Kanamaru","year":"2011","journal-title":"Acta Neurochir Suppl (Wien)"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4103\/ajns.AJNS_220_18","article-title":"Superficial temporal artery: middle cerebral artery bypass, our series of 20 cases, surgical technique and indications with illustrative cases","volume":"14","author":"A Cheikh","year":"2019","journal-title":"Asian J Neurosurg"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1227\/NEU.0b013e318207a9de","article-title":"Superficial temporal artery to middle cerebral artery bypass in acute ischemic stroke and stroke in progress","volume":"68","author":"G Hwang","year":"2011","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1227\/01.NEU.0000315873.41953.74","article-title":"Cerebral revascularization for ischemia, aneurysms, and cranial base tumors","volume":"62","author":"L N Sekhar","year":"2008","journal-title":"Neurosurgery"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13311-011-0053-1","article-title":"Stroke epidemiology: advancing our understanding of disease mechanism and therapy","volume":"8","author":"B Ovbiagele","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref7","first-page":"18","volume-title":"Risk factors for stroke, assessing risk, and the mass and high-risk approaches for stroke prevention","author":"J SR Chong","year":"2005"},{"issue":"04","key":"ref8","first-page":"e18","article-title":"Heart disease and stroke statistics\u20132011 update: a report from the American Heart Association","volume":"123","author":"V L Roger","year":"2011","journal-title":"Circulation"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1161\/01.STR.29.10.2109","article-title":"Incidence of transient ischemic attack in Rochester, Minnesota, 1985-1989","volume":"29","author":"R D Brown Jr","year":"1998","journal-title":"Stroke"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.atherosclerosis.2018.12.015","article-title":"Risk factors for intracranial atherosclerosis: a systematic review and meta-analysis","volume":"281","author":"Y H Ma","year":"2019","journal-title":"Atherosclerosis"},{"issue":"18","key":"ref11","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1001\/jama.2011.1610","article-title":"Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial","volume":"306","author":"W J Powers","year":"2011","journal-title":"JAMA"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"e599","DOI":"10.1161\/STROKEAHA.120.033991","article-title":"Patients receiving extracranial to intracranial bypass for atherosclerotic vessel occlusion today differ significantly from the COSS population","volume":"52","author":"L Wessels","year":"2021","journal-title":"Stroke"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1227\/ons.0000000000000280","article-title":"Extracranial-to-intracranial bypass for distal internal carotid artery and\/or proximal middle cerebral artery steno-occlusive disease: a case series of clinical outcomes at a single, high-volume cerebrovascular center","volume":"23","author":"S B Housley","year":"2022","journal-title":"Oper Neurosurg (Hagerstown)"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000354159","article-title":"Extra-intracranial standard bypass in the elderly: perioperative risk, bypass patency and outcome","volume":"36","author":"N Sandow","year":"2013","journal-title":"Cerebrovasc Dis"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1227\/NEU.0000000000001846","article-title":"Factors influencing long-term blood flow in extracranial-to-intracranial bypass for symptomatic internal carotid artery occlusive disease: a quantitative study","volume":"90","author":"Y Murai","year":"2022","journal-title":"Neurosurgery"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10143-016-0736-5","article-title":"Long-term patency of superficial temporal artery to middle cerebral artery bypass for cerebral atherosclerotic disease: factors determining the bypass patent","volume":"39","author":"F Matano","year":"2016","journal-title":"Neurosurg Rev"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2521-3005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T22:42:48Z","timestamp":1754520168000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2521-3005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":16,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,8,6]]},"published-print":{"date-parts":[[2025,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2521-3005","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"type":"print","value":"2193-6315"},{"type":"electronic","value":"2193-6323"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}