{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:06:23Z","timestamp":1760403983847,"version":"build-2065373602"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this single center cohort study was to examine the possible effects of SARS-CoV-2 infection, especially the Omicron variant, on outcome of pregnancy and birth after infertility treatment with assisted reproduction.<\/jats:p><jats:p>A total of 51 pregnancies and births after assisted reproduction were investigated in the period from 01\/2022 to 12\/2022 in a university fertility center with regards to SARS-CoV-2 infections and vaccination status. Eight multiple pregnancies were assessed separately. 20 women with singleton pregnancy had a confirmed SARS-CoV-2 infection in the six months prior to or during the pregnancy. This group was compared to 23 singleton pregnancies without SARS-CoV-2 infection or with infection had occurred more than six months before assisted reproduction.<\/jats:p><jats:p>The comparison of single pregnancy with or without SARS-CoV-2 showed no differences considering age or body mass index. Complications of pregnancy such as preeclampsia, pregnancy-induced hypertension, placenta previa, placental insufficiency, and preterm labor were also comparable for both groups. There were no significant differences between the two groups with regards to gestational age at delivery, birth weight, birth mode, and APGAR scores. A comparison of the course of pregnancy in women with and women without basic immunization also showed no significant differences.<\/jats:p><jats:p>In the study period of 2022, infection with SARS-CoV-2, in most cases with the Omicron variant, during or up to six months prior to a pregnancy following assisted reproduction did not significantly affect the risk of maternal and fetal complications of pregnancy from the 2nd trimester of pregnancy or the fetoneonatal outcome.<\/jats:p>","DOI":"10.1055\/a-2524-2474","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:42:37Z","timestamp":1747683757000},"page":"1081-1089","source":"Crossref","is-referenced-by-count":0,"title":["Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction"],"prefix":"10.1055","volume":"85","author":[{"given":"Violet","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Gla\u00df","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Schaar","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Wimberger","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-2424","authenticated-orcid":false,"given":"Maren","family":"Goeckenjan","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ejogrb.2023.11.027","article-title":"Does SARS Cov-2 infection affect the IVF outcome \u2013 A systematic review and meta-analysis","volume":"292","author":"H Kaur","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1093\/humrep\/deab218","article-title":"Outcomes of SARS-CoV-2 infected pregancies after medically assisted reproduction","volume":"36","author":"B Ata","year":"2021","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00404-023-07228-w","article-title":"Assisted reproduction after SARS-CoV-2-infection: results of a single-center cohort-study","volume":"309","author":"V Eckstein","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255994","article-title":"COVID-19 and cause of pregnancy loss during the pandemic: A systematic review","volume":"16","author":"SN Kazemi","year":"2021","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s00129-020-04637-9","article-title":"Schwangerschaft, Geburt und Wochenbett mit SARS-CoV-2 und COVID-19 [Pregnancy, birth, and puerperium with SARS-CoV-2 and COVID-19]","volume":"53","author":"C Hagenbeck","year":"2020","journal-title":"Gynakologe"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1093\/humrep\/deac062","article-title":"SARS-CoV-2 infection in the first trimester and the risk of early miscarriage: a UK population-based prospective cohort study of 3041 pregnancies conceived during the pandemic","volume":"37","author":"N Balachandren","year":"2022","journal-title":"Hum Reprod"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3238\/arztebl.m2022.0266","article-title":"The CRONOS registry. 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Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study","volume":"401","author":"J Villar","year":"2023","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e2434","DOI":"10.1002\/rmv.2434","article-title":"Effects of COVID-19 vaccination during pregnancy on SARS-CoV-2 infection and maternal and neonatal outcomes: A systematic review and meta-analysis","volume":"33","author":"M Rahmati","year":"2023","journal-title":"Rev Med Virol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.fertnstert.2022.12.022","article-title":"The type of SARS-CoV-2 vaccine does not affect ovarian function in assisted reproduction cycle","volume":"119","author":"A Requena","year":"2023","journal-title":"Fertil Steril"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3238\/arztebl.m2023.0072","article-title":"Immunity Against SARS-CoV-2 in the German Population","volume":"120","author":"K Schulze-Wundling","year":"2023","journal-title":"Dtsch Arztebl Int"}],"container-title":["Geburtshilfe und Frauenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2524-2474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:39:57Z","timestamp":1760395197000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2524-2474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,13]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2524-2474","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0016-5751","1438-8804"],"issn-type":[{"type":"print","value":"0016-5751"},{"type":"electronic","value":"1438-8804"}],"subject":[],"published":{"date-parts":[[2025,5,19]]}}}