{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:16:34Z","timestamp":1787073394986,"version":"build-2736575974"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n            Background\u2002Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer. High-risk colorectal colitis-associated neoplasia (HR-CAN) can be difficult to treat using traditional endoscopic resection methods. This study evaluated the outcomes of endoscopic submucosal dissection (ESD) in patients with IBD and HR-CANs.<\/jats:p><jats:p>\n            Methods\u2002This retrospective multicenter study consecutively included patients with IBD who were referred to expert Italian endoscopy centers for ESD or hybrid ESD (hESD) of HR-CANs. The main outcomes were rates of en bloc, R0, and curative resections, adverse events, local recurrence, metachronous lesions, and post-resection surgery. Kaplan\u2013Meier method was used to analyze survival rates. Risk factors associated with the main outcomes were investigated by univariable analysis.<\/jats:p><jats:p>\n            Results\u200291 patients with colonic IBD (disease duration 15.3 [SD 8.7] years, 82.4\u200a% with ulcerative colitis) with 96 HR-CANs (mean size 34.8 [SD 16.2] mm, 53.1\u200a% high grade dysplasia\/adenocarcinoma) were included. ESD and hESD were performed in 82.3\u200a% and 17.7\u200a%, respectively. En bloc, R0, and curative resections were achieved in 95.8\u200a% (95\u200a%CI 89.6\u201398.8), 85.4\u200a% (95\u200a%CI 76.7\u201391.7), and 83.3\u200a% (95\u200a%CI 74.3\u201390.1). Adverse events occurred in 12.5\u200a% (95\u200a%CI 6.6\u201320.8), which were all conservatively managed. After a mean follow-up of 23.4 (SD 16.1) months, local recurrence and metachronous lesions each occurred in 3.1\u200a%. Post-resection surgery was required in 11.5\u200a%.<\/jats:p><jats:p>\n            Conclusions\u2002ESD of HR-CANs showed favorable outcomes on the medium- and long-term course in patients with IBD.<\/jats:p>","DOI":"10.1055\/a-2524-3553","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T23:48:27Z","timestamp":1737676107000},"page":"658-666","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of endoscopic submucosal dissection for high-risk colorectal colitis-associated neoplasia in inflammatory bowel disease"],"prefix":"10.1055","volume":"57","author":[{"given":"Roberta","family":"Maselli","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"de Sire","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"},{"name":"IBD Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-5952","authenticated-orcid":false,"given":"Paolo","family":"Cecinato","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, IRCCS Azienda Ospedaliera Universitaria di Bologna, Bologna, Italy"},{"name":"Gastroenterology and Digestive Endoscopy, Azienda USL di Reggio Emilia, IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Andrisani","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Campus Bio-Medico, University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Rosa-Rizzotto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, St. Anthony Hospital, Azienda Ospedale-Universit\u00e0, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sferrazza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, ARNAS Civico \u2013 Di Cristina \u2013 Benfratelli, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarla","family":"Fiori","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, Istituto Europeo di Oncologia, IRCCS, Milan, 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Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spadaccini","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-2266","authenticated-orcid":false,"given":"Antonio","family":"Capogreco","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Massimi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Alfarone","sequence":"additional","affiliation":[{"name":"Gastroenterology, Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Francesco","family":"Chiappetta","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gubbiotti","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, St. Anthony Hospital, Azienda Ospedale-Universit\u00e0, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Menini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy"},{"name":"Division of Gastroenterology, St. Michael\u2019s 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