{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:26Z","timestamp":1787004866895,"version":"build-2736575974"},"reference-count":118,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Coronaviren (CoVs) sind positiv einzelstr\u00e4ngige RNA-Viren, die verschiedene\n                    Tierarten sowie Menschen infizieren k\u00f6nnen. Besonders relevant f\u00fcr Katzen ist\n                    das feline Coronavirus (FCoV), das in Katzenpopulationen weltweit verbreitet\n                    ist. Eine Infektion mit FCoV verl\u00e4uft in der Regel ohne Symptome. In\n                    Mehrkatzenhaushalten entwickeln jedoch etwa 5\u201312% der FCoV-infizierten Katzen\n                    aufgrund von Mutationen im Spike-Gen die feline infekti\u00f6se Peritonitis (FIP).\n                    FIP ist eine immunvermittelte Erkrankung, die bislang immer t\u00f6dlich verlief. Die\n                    Mutationen f\u00fchren zu einem Tropismus-Wechsel von Enterozyten zu Monozyten und\n                    Makrophagen. Der damit verbundene Wechsel in der Virulenz von FCoV f\u00fchrt zu der\n                    charakteristischen granulomat\u00f6sen Vaskulitis und Perivaskulitis, die bei FIP\n                    beobachtet wird. In letzter Zeit gibt es zahlreiche neue Erkenntnisse zur FIP.\n                    So zeigen Studien, dass humanmedizinische antivirale Medikamente, wie das\n                    Nukleosidanalogon GS-441524, bei FIP wirksam sind und betroffenen Katzen eine\n                    \u00dcberlebenschance von bis zu 100% bieten. Zudem wurde eine neuartige\n                    FCoV-Variante, das FCoV-23, bei Katzen aus Zypern identifiziert. Dieses Virus\n                    entstand nach derzeitigem Kenntnisstand durch eine Rekombination zwischen FCoV\n                    und dem hochvirulenten pantropischen caninen Coronavirus; es kann direkt von\n                    Katze zu Katze \u00fcbertragen werden und FIP ausl\u00f6sen. Dar\u00fcber hinaus gibt es immer\n                    mehr Hinweise darauf, dass FIP h\u00e4ufig mit einer Myokarditis assoziiert ist.\n                    Dieser Artikel bietet einen \u00dcberblick \u00fcber den aktuellen Wissensstand der FIP,\n                    unter Ber\u00fccksichtigung der Pathologie, klinischer Symptome, wirksamer\n                    Therapiem\u00f6glichkeiten und Pr\u00e4ventionsma\u00dfnahmen.<\/jats:p>","DOI":"10.1055\/a-2524-3760","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T19:03:36Z","timestamp":1744743816000},"page":"96-102","source":"Crossref","is-referenced-by-count":2,"title":["Die feline infekti\u00f6se Peritonitis \u2013 ein aktueller\n                    \u00dcberblick"],"prefix":"10.1055","volume":"53","author":[{"given":"Katharina","family":"Zwicklbauer","sequence":"additional","affiliation":[{"name":"Kleintierklinik, LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Kleintierklinik, LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Alberer","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr P\u00e4diatrische Infektionskrankheiten, Dr. von Haunersches\n                    Kinderspital, LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"von Both","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr P\u00e4diatrische Infektionskrankheiten, Dr. von Haunersches\n                    Kinderspital, LMU M\u00fcnchen"},{"name":"Deutsches Zentrum f\u00fcr Infektionsforschung (DZIF), Partnerstandort\n                    M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Kleintierklinik, LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803109-4.00017-9","article-title":"Family coronaviridae","volume":"158","author":"S Payne","year":"2017","journal-title":"Viruses"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0065-3527(06)66005-3","article-title":"The molecular biology of coronaviruses","volume":"66","author":"P S Masters","year":"2006","journal-title":"Adv Virus Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"F 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