{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:26:46Z","timestamp":1776871606130,"version":"3.51.2"},"reference-count":70,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although endoscopic resection (ER) is recommended as first-choice treatment for early esophageal neoplasia, patients with esophageal varices are considered a high-risk group owing to an increased risk of bleeding. This systematic review aimed to evaluate the effectiveness and safety of ER in this specific patient category.<\/jats:p><jats:p>We searched for studies reporting on clinical outcomes of ER in the presence of esophageal varices, irrespective of study design or follow-up time. End points included the incidence of prophylactic measures to reduce the risk of variceal hemorrhage, radical and curative resection rates, and adverse events.<\/jats:p><jats:p>After screening 2371 studies, 42 studies (including our own unpublished cohort) with a total of 186 patients were included in this systematic review. Endoscopic band ligation (72\/186; 39%) and endoscopic injection sclerotherapy (22\/186; 12%) were the prophylactic measures most widely adopted to eradicate varices prior to ER. Other frequently described prophylactic measures included direct varix coagulation during ER (18\/186; 10%) and the placement of a transjugular intrahepatic portosystemic shunt prior to ER (9\/186; 5%). While the radical and curative resection rates were high (86% and 72%, respectively), the periprocedural and delayed bleeding risks were reported to be relatively low (6% and 3%, respectively). In all studies, no procedure-related mortality was observed.<\/jats:p><jats:p>ER appeared to be a safe and effective treatment option in selected patients with concurrent early esophageal neoplasia and esophageal varices, provided that a tailored approach of adequate prophylactic measures to prevent bleeding is applied.<\/jats:p>","DOI":"10.1055\/a-2524-4148","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:06:17Z","timestamp":1737763577000},"page":"769-777","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic resection of early esophageal neoplasia in patients with esophageal varices: a systematic review"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-1253","authenticated-orcid":false,"given":"Charlotte N.","family":"Frederiks","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, Netherlands"},{"name":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura S.","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, Netherlands"},{"name":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas","family":"Gloudemans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Alvarez Herrero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Antonius Hospital, 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