{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:23:44Z","timestamp":1770906224910,"version":"3.50.1"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since the first intrauterine interventions were carried out in the 1970\u200as under what today would be considered basic conditions, the range of prenatal interventions has steadily expanded, as has the frequency with which these interventions are carried out at specialized centers. Although most of these procedures are minimally invasive, they are invariably associated with considerable risks for the fetus and, depending on the surgical method, also for the expectant mother. For this reason, most centers worldwide limit themselves to interventions for fetal diseases which, if untreated, have a fatal course or experience a significant deterioration in the postnatal prognosis during the course of intrauterine development. This is all the more significant as only a small proportion of prenatal interventions have been successfully investigated in controlled clinical trials. The only exceptions are laser therapy for feto-fetal transfusion syndrome, intrauterine closure of spina bifida, and tracheal occlusion for diaphragmatic hernia with severe pulmonary hypoplasia. This article is intended to provide an overview of the fetal conditions that are candidates for intrauterine therapy and of the evidence for the individual interventions.<\/jats:p>","DOI":"10.1055\/a-2524-5787","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T21:13:01Z","timestamp":1741986781000},"page":"440-471","source":"Crossref","is-referenced-by-count":2,"title":["Intrauterine Therapy"],"prefix":"10.1055","volume":"46","author":[{"given":"Ingo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, Gynecological Sonography and Fetal Surgery, University of Cologne, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Christin","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, Gynecological Sonography and Fetal Surgery, University of Cologne, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivonne","family":"Bedei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Prenatal Medicine, University Hospitals Gie\u00dfen and Marburg, Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Prenatal Medicine, University Hospitals Gie\u00dfen and Marburg, Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-7097","authenticated-orcid":false,"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[{"name":"Department for Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Prenatal Medicine, Gynecological Sonography and Fetal Surgery, University of Cologne, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bpobgyn.2022.03.013","article-title":"Twin-to-twin transfusion syndrome: Controversies in the diagnosis and management","volume":"84","author":"C Bamberg","year":"2022","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1515\/JPM.2010.147","article-title":"Twin-to-twin transfusion syndrome (TTTS)","volume":"39","author":"WAPM Consensus Group on Twin-to-Twin Transfusion, Baschat A, Chmait RH, et al","year":"2011","journal-title":"J Perinat Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1056\/NEJMoa032597","article-title":"Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome","volume":"351","author":"M-V Senat","year":"2004","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/uog.17520","article-title":"Fetoscopic laser coagulation in 1020 pregnancies with twin\u2013twin transfusion syndrome demonstrates improvement in double-twin survival rate","volume":"50","author":"W Diehl","year":"2017","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"n\/a","DOI":"10.1002\/uog.12492","article-title":"Fetoscopic laser ablation of placental anastomoses in twin-twin transfusion syndrome using \u201cSolomon technique\u201d","volume":"25","author":"R Ruano","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.placenta.2017.02.023","article-title":"What is the impact of placental tissue damage after laser surgery for twin-twin transfusion syndrome?","volume":"52","author":"J Akkermans","year":"2017","journal-title":"A secondary analysis of the Solomon trial. 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