{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:58:40Z","timestamp":1782345520840,"version":"3.54.5"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"13","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"crossref","award":["Research Grant 8716"],"award-info":[{"award-number":["Research Grant 8716"]}],"id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to compare growth outcomes and tolerance among very low birth weight (VLBW) infants receiving a new, liquid human milk fortifier (LHMF-NEW) or a human milk fortifier-acidified liquid (HMF-AL).<\/jats:p><jats:p>Retrospective, multicenter study of 515 VLBW infants in three regional neonatal intensive care units. The primary objective was to compare growth velocity (g\/kg\/d) during fortification between groups by repeated measures regression. Secondary outcomes of interest were feeding tolerance and the incidence of late-onset sepsis, necrotizing enterocolitis, and metabolic acidosis. Student's t, analysis of variance, Wilcoxon, and Kruskal\u2013Wallis tests were used for numeric variables, or chi-squared and Fisher's exact test for categorical variables.<\/jats:p><jats:p>No demographic differences were identified between the groups (HMF-AL, n\u2009=\u2009242; LHMF-NEW, n\u2009=\u2009273). Growth velocity during fortification was significantly higher in the group receiving LHMF-NEW, despite relatively similar total fluid, calorie, or protein intake (p\u2009=\u20090.001). Feeding intolerance was comparable between fortifiers. Necrotizing enterocolitis and late-onset sepsis did not differ between groups and metabolic acidosis was diagnosed less frequently with the LHMF-NEW. Anthropometric measures at discharge and length of stay were comparable.<\/jats:p><jats:p>Infants receiving human milk fortified with the LHMF-NEW had faster growth velocity during fortification, similar tolerance, and less metabolic acidosis compared with an earlier cohort of infants who received human milk fortified with an HMF-AL.<\/jats:p>","DOI":"10.1055\/a-2527-4638","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:53:27Z","timestamp":1738176807000},"page":"1729-1737","source":"Crossref","is-referenced-by-count":3,"title":["Improved Growth Velocity Using a New Liquid Human Milk Fortifier in Very Low Birth Weight Infants: A Multicenter, Retrospective Study"],"prefix":"10.1055","volume":"42","author":[{"given":"Fernando","family":"Moya","sequence":"additional","affiliation":[{"name":"Betty Cameron Children's Hospital and University of North Carolina Medical School, Wilmington, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fowler","sequence":"additional","affiliation":[{"name":"East Carolina University Health Medical Center, Greenville, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Florens","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kidz Medical Services, Palm Beach Children's Hospital, Palm Beach, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Dombrowski","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kidz Medical Services, Palm Beach Children's Hospital, Palm Beach, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kidz Medical Services, Palm Beach Children's Hospital, Palm Beach, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffony","family":"Blanks","sequence":"additional","affiliation":[{"name":"Betty Cameron Children's Hospital and University of North Carolina Medical School, Wilmington, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Gratton","sequence":"additional","affiliation":[{"name":"Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"issue":"21","key":"ref1","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.3390\/nu15214644","article-title":"The influence of early nutrition on neurodevelopmental outcomes in preterm infants","volume":"15","author":"R C 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