{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T03:16:22Z","timestamp":1766546182045,"version":"3.40.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n      In den Industrienationen nimmt die Inzidenz und Pr\u00e4valenz der Harnsteinerkrankung zu. Ein Anstieg wird vor allem bei jungen Erwachsenen und Frauen beobachtet. Die Verteilung zwischen den Geschlechtern (historisch 3:1) gleicht sich immer mehr an. F\u00fcr die USA wurde bereits ein Geschlechtergleichstand (1:1) dokumentiert.\n   Frauen weisen in Studien im Vergleich zu M\u00e4nnern h\u00f6here Urin-pH-Werte auf, die eine Kalziumphosphatkristallisation beg\u00fcnstigen. Die bevorzugte Kalziumoxalat- und Harns\u00e4uresteinbildung bei M\u00e4nnern wird durch die im Vergleich niedrigeren Urin-pH-Werte hervorgerufen.\n      \n     Die Fehlern\u00e4hrung in Kombination mit Bewegungsmangel und dem vermehrten Auftreten des metabolischen Syndroms mit den zugrunde liegenden Erkrankungen (Insulinresistenz, Diabetes mellitus Typ 2, Adipositas, Dyslipid\u00e4mie) wird als Ursache der Zunahme der Harnsteinerkrankung in den Industriel\u00e4ndern diskutiert. Zu den Folgeerkrankungen des metabolischen Syndroms wird die nicht-alkoholische Leberverfettung (NAFLD) als h\u00e4ufigste Lebererkrankung mit einer Pr\u00e4valenz von ca. 23% in Deutschland gez\u00e4hlt.\n      \n   Tierexperimentelle und klinische Untersuchungen konnten einen Zusammenhang zwischen der NAFLD und einer erh\u00f6hten Oxals\u00e4ureausscheidung im Urin nachweisen. In Kenntnis der Literatur stellt die NAFLD einen m\u00f6glichen, geschlechter\u00fcbergreifenden Risikofaktor der Harnsteinbildung dar und ger\u00e4t somit in das Blickfeld der allgemein modifizierbaren Risikofaktoren der rezidivierenden Harnsteinerkrankung. Einfache, die NAFLD betreffende Empfehlungen sollten die allgemeine Steinmetaphylaxe im klinischen Alltag erweitern.\n    <\/jats:p>","DOI":"10.1055\/a-2528-0260","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:06:11Z","timestamp":1741824371000},"page":"145-149","source":"Crossref","is-referenced-by-count":1,"title":["Geschlechtsspezifische Unterschiede der Harnsteinerkrankung unter Beachtung des Oxalatstoffwechsels der Leber"],"prefix":"10.1055","volume":"56","author":[{"given":"Roman","family":"Herout","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Urologie, Universit\u00e4tsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Oehlschl\u00e4ger","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Urologie, Universit\u00e4tsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"volume-title":"Die 50 h\u00e4ufigsten Diagnosestellungen (ICD-10 Schl\u00fcssel-nummern) des Gesamtjahres 2006 f\u00fcr 12 ausgew\u00e4hlte Fachgebiete","year":"2007","author":"H Koch","key":"ref1"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s001200050026","article-title":"Socioeconomic aspects of urinary calculi and metaphylaxis of urinary calculi","volume":"39","author":"WL Strohmaier","year":"2000","journal-title":"Urologe A"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.juro.2012.03.021","article-title":"Temporal trends in incidence of kidney stones among children: a 25-year population based study","volume":"188","author":"ME Dwyer","year":"2012","journal-title":"J 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