{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:47:56Z","timestamp":1741308476975,"version":"3.38.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A proportion of patients with primary aldosteronism (PA) have a paradox\n                    increasein plasma-Aldosterone (P-Aldosterone) concentration (PAC) during the\n                    Captopril Challenge Test (CCT). This study aimed to investigate if a paradoxical\n                    rise in PAC during CCT, was associated with clinical characteristics or outcomes\n                    inpatients with PA. We hypothesized that a paradoxical response to CCT is\n                    ameasure of disease severity, reflected by a higher baseline\n                    aldosterone\/renin-ratio (ARR). A retrospective study of patients with\n                    PA,confirmed by CCT, who were referred for adrenal venous sampling between May\n                    2011and August 2021 were eligible. Patients with an increase in PAC&gt;10%\n                    frombaseline during CCT were classified as cases, while patients with 10 to 30%\n                    suppression were classified as controls. Of 167 patients referred, 116 (70%)\n                    were eligible for this study. Based on the CCT, 61\/116 (53%) were classified as\n                    cases while 55\/116 (47%) were classified as controls. The baseline ARR was\n                    122\u2009pmol\/mIU (IQR: 65 to 223) for cases and 137 pmol\/mIU (IQR: 65 to 223) for\n                    controls (p=0.66). Cases had lower systolic blood pressure (p=0.02) and\n                    higherpotassium levels (p=0.05) compared to controls. Complete clinical\n                    remission was obtained in 22 of 31 (71%) of the cases and 13 of 27 (48%) of the\n                    controls (p=0.03) after adrenalectomy. In conclusion, a paradoxical response to\n                    CCT wasnot associated with ARR. By contrast, patients with a paradoxical\n                    response did have lower systolic blood pressure, higher potassium levels, and\n                    markedly higher odds of full clinical remission after adrenalectomy.<\/jats:p>","DOI":"10.1055\/a-2528-7526","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:03:51Z","timestamp":1741305831000},"page":"156-162","source":"Crossref","is-referenced-by-count":0,"title":["Primary Aldosteronism: Clinical Characteristics of Patients with a\n                    Paradoxical Increase in P-Aldosterone in Response to Captopril Challenge\n                    Test"],"prefix":"10.1055","volume":"57","author":[{"given":"Camilla","family":"Grindskar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Endocrinology and Metabolism, Copenhagen\n                    University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Endocrinology and Metabolism, Copenhagen\n                    University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen,\n                    Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus Larsen","family":"Feltoft","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital \u2013 Herlev,\n                    Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebbe","family":"Eldrup","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital \u2013 Herlev,\n                    Herlev, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen,\n                    Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi Kj\u00e6rsgaard","family":"Ugleholdt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Copenhagen University Hospital \u2013 Herlev,\n                    Herlev, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen,\n                    Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas Rye","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Translational Research Centre, Copenhagen University Hospital \u2013\n                    Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen,\n                    Denmark"},{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital \u2013\n                    Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"M\u00f8rup","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Endocrinology and Metabolism, Copenhagen\n                    University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Endocrinology and Metabolism, Copenhagen\n                    University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Krogh","sequence":"additional","affiliation":[{"name":"Clinic for Pituitary Disorders, Department of Medicine,\n                    Zealand University Hospital Koge, Koge, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen,\n                    Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/jc.2016-1472","article-title":"Study heterogeneity and estimation of prevalence of primary aldosteronism: a\n                    systematic review and meta-regression analysis","volume":"101","author":"S C K\u00e4yser","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.5694\/mja2.51438","article-title":"Detecting primary aldosteronism in Australian primary care: a prospective\n                    study","volume":"216","author":"R Libianto","year":"2022","journal-title":"Med J Aust"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and\n                    treatment: an endocrine society clinical practice guideline","volume":"101","author":"J W Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1161\/HYPERTENSIONAHA.122.19377","article-title":"Performance of confirmatory tests for diagnosing primary aldosteronism: a\n                    systematic review and meta-analysis","volume":"79","author":"A A Leung","year":"2022","journal-title":"Hypertension"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1210\/clinem\/dgac654","article-title":"Exclusion tests in unilateral primary aldosteronism (ExcluPA) study","volume":"108","author":"R Zhu","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1210\/jc.2011-2504","article-title":"Confirmatory testing in primary aldosteronism","volume":"97","author":"K Nanba","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e230445","DOI":"10.1530\/EC-23-0445","article-title":"Captopril challenge test: an underutilized test in the diagnosis of primary\n                    aldosteronism","volume":"13","author":"S Jahan","year":"2024","journal-title":"Endocr Connect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1507\/endocrj.EJ20-0329","article-title":"Prediction of unilateral hyperaldosteronism on adrenal vein sampling using\n                    captopril challenge test in patients with primary aldosteronism","volume":"68","author":"N Wada","year":"2021","journal-title":"Endocr J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/cen.14836","article-title":"Prognostic value of contralateral suppression on kidney function after surgery\n                    in patients with primary aldosteronism","volume":"98","author":"N Voss","year":"2023","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/cen.14678","article-title":"Prognostic value of contralateral suppression for remission after surgery in\n                    patients with primary aldosteronism","volume":"96","author":"S M\u00f8rup","year":"2022","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.plabm.2016.11.002","article-title":"Screening for primary aldosteronism using the newly developed\n                        IDS-iSYS\u00ae automated assay system","volume":"7","author":"P M O\u2019Shea","year":"2016","journal-title":"Pract Lab Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an\n                    international consensus on outcome measures and analysis of remission rates in\n                    an international cohort","volume":"5","author":"T A Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ecl.2019.08.012","article-title":"Adrenal venous sampling: where do we atand?","volume":"48","author":"G P Rossi","year":"2019","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1183161","DOI":"10.3389\/fendo.2023.1183161","article-title":"Captopril challenge test in the diagnosis of primary aldosteronism: consistency\n                    between 1- and 2- h sampling","volume":"14","author":"X Liu","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e762","DOI":"10.1210\/clinem\/dgz190","article-title":"Kinetics and interrelations of the renin aldosterone response to acute\n                    psychosocial stress: a neglected stress system","volume":"105","author":"A Gideon","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s42000-024-00583-6","article-title":"Examining aldosterone plasma concentration alterations post-ACTH stimulation in\n                    healthy subjects: a systematic literature review and meta-analysis on ACTH\u2019s\n                    role in aldosterone secretion","volume":"23","author":"G Stathori","year":"2024","journal-title":"Hormones (Athens)"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2528-7526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:04:14Z","timestamp":1741305854000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2528-7526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":16,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,3,6]]},"published-print":{"date-parts":[[2025,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2528-7526","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}