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Insgesamt wurde in den bisherigen \u00dcberarbeitungen der Leitlinie ein zunehmender Fokus auf die genetischen Aspekte der Erkrankung gelegt und entsprechende Risikogruppen f\u00fcr das Auftreten dieser Neoplasie konkretisiert (u.\u00a0a. das Vorliegen einer CDH1-Mutation oder HNPCC-Tr\u00e4ger*innen). Des Weiteren wurden auch zunehmend \u201eGrenzf\u00e4lle\u201c der Chirurgie in der Leitlinie betrachtet, etwa solche Patient*innen mit Oligometastasierung oder Peritonealkarzinose. Diese Patientenkollektive sollten jedoch weiterhin zun\u00e4chst nur im Rahmen von Studien behandelt werden. Schlie\u00dflich wird\n      in der Leitlinie neben dem derzeitigen chemotherapeutischen Standard der Behandlung analog zum FLOT-Regime auch der zunehmende Einsatz der Immuntherapie in aktuellen und zuk\u00fcnftigen Behandlungsregimen diskutiert. Neue zielgerichtete Therapieans\u00e4tze wie die monoklonalen Antik\u00f6rper gegen Claudin 18.2 werden die Behandlung des Magenkarzinoms erg\u00e4nzen und sicherlich Bestandteil der n\u00e4chsten Version der Leitlinie sein.<\/jats:p>","DOI":"10.1055\/a-2529-5300","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:15:41Z","timestamp":1744154141000},"page":"163-166","source":"Crossref","is-referenced-by-count":0,"title":["Neuerungen der aktuellen Leitlinie zum Magenkarzinom und Ausblick in die Zukunft"],"prefix":"10.1055","volume":"150","author":[{"given":"Robert","family":"Nowotny","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Viszeral-, Transplantations-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Leipzig, Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Rhode","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr 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