{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:52:32Z","timestamp":1770742352199,"version":"3.49.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evaluation of the possible role of microvascular imaging (MI) for the detection of vascularization of renal lesions, while comparing it with contrast-enhanced ultrasound (CEUS).<\/jats:p>\n                  <jats:p>137 patients (160 renal lesions, 64 solid and 96 cystic) were enrolled in this single-center, retrospective, observational study. For solid masses, both the intralesional and the peripheral vascularization was analyzed and quantified by MI and then compared to peak enhancement on CEUS. Regarding cystic lesions, we evaluated the presence or absence of vascularization within the cystic wall and\/or septa. MI results were compared with CEUS findings using Pearson\u2019s Chi square test. An optimal size cut-off for renal lesions was determined with the Youden test.<\/jats:p>\n                  <jats:p>For solid lesions, a statistically significant correlation (p &lt;0.05) was observed between the MI parameters and the peak enhancement on CEUS. The detection rate (DR) for lesional vascularization on MI was 87.5%, while if we consider only lesions larger than the optimal cut-off (14mm), the DR increases to 98%. In cystic lesions, the MI showed a high specificity (93.9%) in predicting CEUS results and a high positive predictive value (84.2%). The concordance was 100% in Bosniak I lesions and 80% in Bosniak IV lesions, while it was lower for the other classes. Furthermore, we found a statistically significant correlation (p &lt;0.05) between Bosniak grade and lesional vascularity on MI.<\/jats:p>\n                  <jats:p>Our preliminary study shows that MI cannot replace CEUS, but could reduce its use, especially in solid lesions larger than 14mm and in cysts classified as Bosniak IV, a goal that is particularly important in an active surveillance setting.<\/jats:p>","DOI":"10.1055\/a-2532-6772","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T19:12:19Z","timestamp":1743448339000},"page":"75-85","source":"Crossref","is-referenced-by-count":1,"title":["Microvascular imaging versus CEUS in the characterization of renal masses: preliminary experience in a tertiary care referral university hospital"],"prefix":"10.1055","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-7733","authenticated-orcid":false,"given":"Elena","family":"Bertelli","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5822-1935","authenticated-orcid":false,"given":"Michele","family":"Vizzi","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Lattavo","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Ruzga","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7028-9047","authenticated-orcid":false,"given":"Diletta","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Valeri","sequence":"additional","affiliation":[{"name":"Health Physics, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Agostini","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Miele","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Careggi, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.eururo.2018.08.036","article-title":"Epidemiology of Renal Cell Carcinoma","volume":"75","author":"U Capitanio","year":"2019","journal-title":"Eur Urol"},{"issue":"03","key":"ref2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1001\/jamasurg.2018.4602","article-title":"Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014","volume":"154","author":"JH Kim","year":"2019","journal-title":"JAMA Surg"},{"issue":"05","key":"ref3","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.juro.2015.11.029","article-title":"Diagnostic Accuracy and Risks of Biopsy in the Diagnosis of a Renal Mass Suspicious for Localized Renal Cell Carcinoma: Systematic Review of the Literature","volume":"195","author":"HD Patel","year":"2016","journal-title":"J Urol"},{"issue":"04","key":"ref4","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.eururo.2015.07.072","article-title":"Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy","volume":"69","author":"L Marconi","year":"2016","journal-title":"Eur Urol"},{"issue":"02","key":"ref6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1055\/a-1300-1727","article-title":"EFSUMB 2020 Proposal for a Contrast-Enhanced Ultrasound-Adapted Bosniak Cyst Categorization \u2013 Position Statement. EFSUMB 2020 \u2013 Vorschlag f\u00fcr eine an den kontrastverst\u00e4rkten Ultraschall adaptierte Bosniak-Klassifikation von Zysten \u2013 Eine Stellungnahme","volume":"42","author":"V Cantisani","year":"2021","journal-title":"Ultraschall in Med"},{"issue":"04","key":"ref7","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.euo.2019.08.013","article-title":"Comparison of the Diagnostic Performance of Contrast-enhanced Ultrasound with That of Contrast-enhanced Computed Tomography and Contrast-enhanced Magnetic Resonance Imaging in the Evaluation of Renal Masses: A Systematic Review and Meta-analysis","volume":"3","author":"MA Furrer","year":"2020","journal-title":"Eur Urol Oncol"},{"issue":"07","key":"ref8","doi-asserted-by":"publisher","first-page":"e19190","DOI":"10.1097\/MD.0000000000019190","article-title":"How does contrast-enhanced ultrasonography influence Bosniak classification for complex cystic renal mass compared with conventional ultrasonography?","volume":"99","author":"X Qiu","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"08","key":"ref9","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1007\/s00345-021-03589-6","article-title":"Contrast-enhanced ultrasound (CEUS) imaging for active surveillance of small renal masses","volume":"39","author":"E Bertelli","year":"2021","journal-title":"World J Urol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11604-021-01194-6","article-title":"Microvascular imaging ultrasound (MicroV) and power Doppler vascularization analysis in a pediatric population with early scrotal pain onset","volume":"40","author":"C Visalli","year":"2022","journal-title":"Jpn J Radiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"111513","DOI":"10.1016\/j.ejrad.2024.111513","article-title":"Assessment of quantitative microflow Vascular Index in testicular cancer","volume":"176","author":"P Spiesecke","year":"2024","journal-title":"Eur J Radiol"},{"issue":"06","key":"ref12","doi-asserted-by":"publisher","first-page":"696","DOI":"10.21037\/tau.2019.11.15.","article-title":"Impact of a novel ultrasound microvascular imaging and elastography on prostate cancer classification","volume":"8","author":"TT Shen","year":"2019","journal-title":"Transl Androl Urol"},{"issue":"10","key":"ref13","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/jum.15299","article-title":"Superb Microvascular Imaging Improves Detection of Vascularity in Indeterminate Renal Masses","volume":"39","author":"JY Leong","year":"2020","journal-title":"J Ultrasound Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6656877","DOI":"10.1155\/2021\/6656877","article-title":"Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor","volume":"2021","author":"M Chen","year":"2021","journal-title":"Contrast Media Mol Imaging"},{"issue":"05","key":"ref15","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3390\/cancers12051172","article-title":"Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches","volume":"12","author":"H Saman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170601","article-title":"The value of superb microvascular imaging in differentiating benign renal mass from malignant renal tumor: a retrospective study","author":"Y Mao","year":"2018","journal-title":"Br J Radiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20181038","article-title":"Superb microvascular imaging is a rational choice for accurate Bosniak classification of renal cystic masses","author":"J Mu","year":"2019","journal-title":"Br J Radiol"},{"issue":"04","key":"ref18","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.3390\/jcm11041112","article-title":"Expanding the Role of Ultrasound for the Characterization of Renal Masses","volume":"11","author":"E Roussel","year":"2022","journal-title":"J Clin Med"},{"issue":"09","key":"ref19","doi-asserted-by":"publisher","first-page":"292.e9","DOI":"10.1016\/j.urolonc.2024.04.026","article-title":"Evaluation of image-pro plus assisted superb microvascular imaging for differential diagnosis of renal masses","volume":"42","author":"Y Mao","year":"2024","journal-title":"Urol Oncol"},{"issue":"02","key":"ref20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.14366\/usg.17043.","article-title":"Up-to-date Doppler techniques for breast tumor vascularity: superb microvascular imaging and contrast-enhanced ultrasound","volume":"37","author":"AY Park","year":"2018","journal-title":"Ultrasonography"}],"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2532-6772.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:42:41Z","timestamp":1770680561000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2532-6772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":19,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,2,9]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2532-6772","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]}}}