{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:42:47Z","timestamp":1769114567536,"version":"3.49.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In patients with primary hyperparathyroidism (pHPT), the importance of oxyphil cells for 99mTc-sestamibi uptake is uncertain.<\/jats:p><jats:p>This retrospective observational study of pHPT patients evaluated independent associations between oxyphil cell content (OCC) and preoperative scintigraphic (SC) findings, using logistic regression analyses.<\/jats:p><jats:p>We studied 76 patients with pHPT before and after operation. Preoperative SC was able to definitively identify abnormal parathyroid tissue in 47 patients (61.8%). The median relative OCC (postoperative histopathological examination) was 10% (IQR 0.25% \u2013 40%) and the median absolute OCC was 0.09 cm3 (IQR 0.00 \u2013 0.59 cm3). After adjustment for confounders, an iPTH concentration &gt;200 pg\/ml and increasing OCC was the only significant independent predictor of a definitively positive SC result (per category of relative OCC: adjusted odds ratio (aOR) 2.40, 95% confidence interval (CI) 1.02 \u2013 5.65, p=0.045).<\/jats:p><jats:p>In patients with pHPT, a higher OCC was associated with a significantly higher probability of a clearly positive SC finding.<\/jats:p>","DOI":"10.1055\/a-2535-1067","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:22:51Z","timestamp":1741306971000},"page":"215-224","source":"Crossref","is-referenced-by-count":1,"title":["Importance of oxyphil cells for 99mTc-sestamibi uptake in primary hyperparathyroidism: a retrospective observational study"],"prefix":"10.1055","volume":"64","author":[{"given":"Jan Axl","family":"Dropmann","sequence":"additional","affiliation":[{"name":"LMU University Hospital, Department of General, Visceral and Transplantation Surgery, Ludwig Maximilian University of Munich, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Kleespies","sequence":"additional","affiliation":[{"name":"LMU University Hospital, Department of General, Visceral and Transplantation Surgery, Ludwig Maximilian University of Munich, M\u00fcnchen, Germany"},{"name":"Department of General, Visceral, Thoracic and Oncological Surgery, HELIOS Amper-Klinikum Dachau, Dachau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Fuerst","sequence":"additional","affiliation":[{"name":"Division of Thyroid Surgery, Isar Klinikum, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Kremer","sequence":"additional","affiliation":[{"name":"Institute of Pathology, M\u00fcnchen Klinik Neuperlach, Munchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Drefs","sequence":"additional","affiliation":[{"name":"LMU University Hospital, Department of General, Visceral and Transplantation Surgery, Ludwig Maximilian University of Munich, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Neuberger","sequence":"additional","affiliation":[{"name":"LMU University Hospital, Department of General, Visceral and Transplantation Surgery, Ludwig Maximilian University of Munich, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/s0001-2998(95)80012-3","article-title":"Sestamibi parathyroid imaging","volume":"25","author":"M McBiles","year":"1995","journal-title":"Semin Nucl 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