{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:08:02Z","timestamp":1744690082697,"version":"3.40.4"},"reference-count":59,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der regelrechte Blutfluss durch mikrochirurgisch anastomosierte Gef\u00e4\u00dfe ist f\u00fcr\n                    den Therapieerfolg der rekonstruktiven Mikrochirurgie post operationem\n                    entscheidend. Im Gegensatz zu inzwischen in weiten Teilen ausgereiften und\n                    standardisierten Anastomosentechniken steht die erfolgsentscheidende\n                    Partnerdisziplin der evidenzbasierten mikrochirurgischen H\u00e4mostaseologie und\n                    H\u00e4morheologie allerdings noch am Anfang. Prospektive klinische Studien und\n                    daraus ableitbare evidenzbasierte Empfehlungen fehlen. Lediglich\n                    standortspezifische Erfahrungswerte bilden heutzutage die Grundlage des\n                    perioperativen Managements in der Mikrochirurgie. Gemeinsames Ziel dieser\n                    mannigfaltigen Bem\u00fchungen sind die pr\u00e4operative Identifikation erh\u00f6hter\n                    Gerinnungsneigungen (Hyperkoagulabilit\u00e4t) oder Gerinnungsaktivit\u00e4ten\n                    (Thrombophilie) und die Formulierung korrespondierender Antikoagulationsregime.\n                    Im Zuge der 43. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft f\u00fcr\n                    Mikrochirurgie (DAM) im November 2022 in Frankfurt wurden Grundlagen der\n                    Gerinnung und Physiologie von Experten der Mikrochirurgie, H\u00e4mostaseologie und\n                    An\u00e4sthesie diskutiert, sowie zusammen mit einem Literatur\u00fcberblick\n                    Konsensusempfehlungen f\u00fcr das perioperative Management von Hyperkoagulopathien\n                    erarbeitet. Im Anschluss wurden im Gremium Vorgehensweisen evaluiert,\n                    Entscheidungskriterien erfragt und schlie\u00dflich ein Empfehlungskonsens der DAM\n                    bzgl. eines perioperativen Algorithmus erarbeitet, der in diesem Positionspapier\n                    festgehalten ist.<\/jats:p>","DOI":"10.1055\/a-2535-2467","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:31:46Z","timestamp":1743723106000},"page":"92-101","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Diagnostik und Management von Hyperkoagulabilit\u00e4t und\n                    Thrombophilie in der Mikrochirurgie \u2013 Konsensus-Bericht der Deutschsprachigen\n                    Arbeitsgemeinschaft f\u00fcr Mikrochirurgie (DAM)"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-178X","authenticated-orcid":false,"given":"Benjamin","family":"Thomas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hand, Plastische und Rekonstruktive Chirurgie,\n                    Schwerbrandverletztenzentrum, BG Unfallklinik Ludwigshafen, Ludwigshafen am\n                    Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Steinfeldt","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr An\u00e4sthesie, Intensivmedizin und Schmerztherapie, BG\n                    Unfallklinik Frankfurt am Main, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Seyfert","sequence":"additional","affiliation":[{"name":"H\u00e4mostaseologie und Transfusionsmedizin, Institut f\u00fcr Blut Forschung,\n                    Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Megerle","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Handchirurgie, Mikrochirurgie und plastische Chirurgie,\n                    Sch\u00f6n Klinik M\u00fcnchen Harlaching, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf-Dieter","family":"Bader","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Mund-, Kiefer- und Gesichtschirurgie,\n                    Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Radtke","sequence":"additional","affiliation":[{"name":"Plastic, Reconstructive and Aesthetic Surgery, Medizinische Universitat\n                    Wien, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-8671","authenticated-orcid":false,"given":"Christoph","family":"Hirche","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Plastische Chirurgie, Hand- und Rekonstruktive\n                    Mikrochirurgie, Handtrauma- und Replantationszentrum, BG Unfallklinik Frankfurt\n                    am Main, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-5132","authenticated-orcid":false,"given":"Amir K.","family":"Bigdeli","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Plastische, Rekonstruktive, \u00c4sthetische und Handchirurgie,\n                    Klinikum Kassel GmbH, Kassel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Kneser","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hand, Plastische und Rekonstruktive Chirurgie,\n                    Schwerbrandverletztenzentrum, BG Unfallklinik Ludwigshafen, Ludwigshafen am\n                    Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Gazyakan","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hand, Plastische und Rekonstruktive Chirurgie,\n                    Schwerbrandverletztenzentrum, BG Unfallklinik Ludwigshafen, Ludwigshafen am\n                    Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurij","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Plastic Surgery, Orlando Health, Orlando, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Behr","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Plastische, Rekonstruktive und \u00c4sthetische Chirurgie, KEM\n                    Evang. Kliniken Essen-Mitte gGmbH, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0094-1298(20)30793-8","article-title":"Free flap surgery. The second decade","volume":"19","author":"R K Khouri","year":"1992","journal-title":"Clin Plast Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1097\/PRS.0000000000004200","article-title":"5000 Free Flaps and Counting","volume":"141","author":"M J Carney","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1055\/a-0874-2159","article-title":"The interdisciplinary Microsurgeon \u2013 Results of the Consensus Workshop of the\n                    German Speaking Society for Microsurgery of Peripheral Nerves and Vessels","volume":"51","author":"V J Schmidt","year":"2019","journal-title":"Handchirurgie Mikrochirurgie Plast Chir"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1002\/MICR.20809","article-title":"Modern adjuncts and technologies in microsurgery: An historical and\n                    evidence-based review","volume":"30","author":"G F Pratt","year":"2010","journal-title":"Microsurgery"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"915e","DOI":"10.1097\/PRS.0000000000002715","article-title":"Advances and Innovations in Microsurgery","volume":"138","author":"J E Park","year":"2016","journal-title":"Plast Reconstr Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/micr.30460","article-title":"Soft tissue free flap for reconstruction of upper extremities: A meta-analysis\n                    on outcome and safety","volume":"39","author":"Y Zhang","year":"2019","journal-title":"Microsurgery"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/micr.30020","article-title":"Free flaps for reconstruction of soft tissue defects in lower extremity: A\n                    meta-analysis on microsurgical outcome and safety","volume":"36","author":"L Xiong","year":"2016","journal-title":"Microsurgery"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/jcm10051016","article-title":"Overall Complication Rates of DIEP Flap Breast Reconstructions in Germany \u2013 A\n                    Multi-Center Analysis Based on the DGPR\u00c4C Prospective National Online Registry\n                    for Microsurgical Breast Reconstructions","volume":"10","author":"P I Heidekrueger","year":"2021","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/01.sap.0000262740.34106.1b","article-title":"The Fate of Lower Extremities With Failed Free Flaps","volume":"59","author":"A T Culliford","year":"2007","journal-title":"Ann Plast Surg"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/704206","article-title":"Catastrophic Outcomes in Free Tissue Transfer: A Six-Year Review of the NSQIP\n                    Database","volume":"2014","author":"D W Grant","year":"2014","journal-title":"Plast Surg Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/PRS.0000000000001134","article-title":"Cost-Effectiveness Analysis of Implants versus Autologous Perforator Flaps Using\n                    the BREAST-Q","volume":"135","author":"E Matros","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1055\/s-0041-1729639","article-title":"The Cost of Care Associated with Microvascular Free Tissue Transfer by\n                    Anatomical Region: A Time-Driven Activity-Based Model","volume":"06","author":"J S Lindell","year":"2021","journal-title":"J Reconstr Microsurg Open"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0007-1226(88)90141-5","article-title":"Analysis of 200 free flaps","volume":"41","author":"T Harashina","year":"1988","journal-title":"Br J Plast Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0094-1298(20)30797-5","article-title":"Thrombosis and antithrombotic therapy in microvascular surgery","volume":"19","author":"P C Johnson","year":"1992","journal-title":"Clin Plast Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1097\/PRS.0b013e3181811ca0","article-title":"Strategy for Reoperative Free Flaps after Failure of a First Flap","volume":"122","author":"S Baumeister","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/PRS.0b013e3181adcf35","article-title":"Microvascular Free Flap Failure Caused by Unrecognized Hypercoagulability","volume":"124","author":"S P Davison","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/SAP.0b013e31823ed606","article-title":"Preoperative Anemia Predicts Thrombosis and Free Flap Failure in Microvascular\n                    Reconstruction","volume":"69","author":"J B Hill","year":"2012","journal-title":"Ann Plast Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1097\/00006534-199906000-00019","article-title":"Algorithm for Recipient Vessel Selection in Free Tissue Transfer to the Lower\n                    Extremity","volume":"103","author":"S Park","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/PRS.0b013e3181addafa","article-title":"Free Tissue Transfer for Lower Extremity Reconstruction: A Study of the Role of\n                    Computed Angiography in the Planning of Free Tissue Transfer in the\n                    Posttraumatic Setting","volume":"124","author":"A Duymaz","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1055\/s-0031-1291317","article-title":"Perioperatives Gerinnungsmanagement in der Mikrochirurgie \u2013 Bericht der\n                    Konsensus-Workshops im Rahmen der 31. und 32. Jahrestagung der Deutschsprachigen\n                    Arbeitsgemeinschaft f\u00fcr Mikrochirurgie der peripheren Nerven und Gef\u00e4\u00dfe (DAM) im\n                    November 2009 in Erla","volume":"43","author":"M Schmitz","year":"2011","journal-title":"Handchirurgie \u00b7 Mikrochirurgie Plast Chir"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3205\/gpras000005","article-title":"A survey of anticoagulation practice among German speaking microsurgeons \u2013\n                    Perioperative management of anticoagulant therapy in free flap surgery","volume":"2","author":"A Jokuszies","year":"2012","journal-title":"GMS Ger Plast Reconstr Aesthet Surg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-0042-108806","article-title":"Perioperatives Management in der Mikrochirurgie \u2013 Konsensus-Statement der\n                    Deutschsprachigen Arbeitsgemeinschaft f\u00fcr Mikrochirurgie der peripheren Nerven\n                    und Gef\u00e4\u00dfe","volume":"48","author":"T Kremer","year":"2016","journal-title":"Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plast Chir"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1126\/science.145.3638.1310","article-title":"Waterfall Sequence for Intrinsic Blood Clotting","volume":"145","author":"E W Davie","year":"1964","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1161\/01.ATV.0000193624.28251.83","article-title":"What Does It Take to Make the Perfect Clot?","volume":"26","author":"D M Monroe","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref25","first-page":"8","volume-title":"H\u00e4mostasesystem. In: H\u00e4mostaseologie. 2nd ed","author":"K Madlener","year":"2010"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/S0140-6736(98)10266-0","article-title":"Venous thrombosis: a multicausal disease","volume":"353","author":"F Rosendaal","year":"1999","journal-title":"Lancet."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2450\/2010.0066-10","article-title":"Risk factors for venous and arterial thrombosis","volume":"9","author":"E Previtali","year":"2011","journal-title":"Blood Transfus"},{"key":"ref28","first-page":"104","article-title":"Lindhoff-Last E. Basiswissen Gerinnungslabor","author":"B Luxembourg","year":"2007","journal-title":"Dtsch Arztebl"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00108-022-01331-x","article-title":"Gerinnungsdiagnostik im klinischen Alltag \u2013 Teil 1","volume":"63","author":"M Metze","year":"2022","journal-title":"Die Inn Medizin"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/PRS.0b013e31823aec4d","article-title":"Free Tissue Transfer in the Hypercoagulable Patient","volume":"129","author":"T Y Wang","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1055\/s-0032-1315771","article-title":"Hypercoagulability in microvascular breast reconstruction: An algorithmic\n                    approach for an underestimated situation","volume":"28","author":"B Sezgin","year":"2012","journal-title":"J Reconstr Microsurg"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"545e","DOI":"10.1097\/PRS.0000000000001591","article-title":"Microsurgery and the Hypercoagulable State: A Hematologist\u2019s Perspective","volume":"136","author":"C J Pannucci","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.bjps.2016.12.001","article-title":"Prevention of thrombosis in hypercoagulable patients undergoing microsurgery: A\n                    novel anticoagulation protocol","volume":"70","author":"J A Nelson","year":"2017","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675145","article-title":"Lower Extremity Free Tissue Transfer in the Setting of Thrombophilia: Analysis\n                    of Perioperative Anticoagulation Protocols and Predictors of Flap Failure","volume":"1","author":"M DeFazio","year":"2018","journal-title":"J Reconstr Microsurg"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1055\/s-0039-3400531","article-title":"Does Anticoagulation Improve Flap Outcomes in Hypercoagulable Patients? A\n                    Systematic Review","volume":"36","author":"V S Kotamarti","year":"2020","journal-title":"J Reconstr Microsurg"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"14e","DOI":"10.1097\/PRS.0000000000008099","article-title":"The Impact of Coagulopathy on Clinical Outcomes following Microsurgical Breast\n                    Reconstruction","volume":"148","author":"F C Liu","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"95S","DOI":"10.1097\/PRS.0000000000009499","article-title":"Microsurgical Breast Reconstruction in Patients with Disorders of Hemostasis:\n                    Perioperative Risks and Management","volume":"150","author":"N E Speck","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12893-022-01639-3","article-title":"The prognostic role of extended preoperative hypercoagulability work-up in\n                    high-risk microsurgical free flaps: a single-center retrospective case series of\n                    patients with heterozygotic factor V Leiden thrombophilia","volume":"22","author":"F Falkner","year":"2022","journal-title":"BMC Surg"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1007\/s00266-015-0575-8","article-title":"Flap Failure and Wound Complications in Autologous Breast Reconstruction: A\n                    National Perspective","volume":"39","author":"B B Massenburg","year":"2015","journal-title":"Aesthetic Plast Surg"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/hed.23624","volume-title":"Influence of diabetes mellitus on postoperative complications and failure in\n                    head and neck free flap reconstruction: A systematic review and meta-analysis.\n                    Eisele DW, ed. Head Neck","author":"P Rosado","year":"2015"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/SAP.0000000000000400","article-title":"Effects of obesity on postoperative complications after breast reconstruction\n                    using free muscle-sparing transverse rectus Abdominis Myocutaneous, deep\n                    inferior epigastric perforator, and superficial inferior epigastric artery flap:\n                    A systematic review and","volume":"76","author":"K T Lee","year":"2016","journal-title":"Ann Plast Surg"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MD.0000000000004072","article-title":"Is obesity a predisposing factor for free flap failure and complications?\n                    Comparison between breast and nonbreast reconstruction","volume":"95","author":"J Y Shin","year":"2016","journal-title":"Med (United States)"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1002\/hed.26349","article-title":"Diabetes mellitus in major head and neck cancer surgery: Systematic review and\n                    meta-analysis","volume":"42","author":"M P Caputo","year":"2020","journal-title":"Head Neck"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.bjps.2022.02.053","article-title":"Impact of diabetes on outcomes in breast reconstruction: A systematic review and\n                    meta-analysis","volume":"75","author":"Q Liu","year":"2022","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/00005373-198908000-00005","article-title":"Reconstruction of the Lower Extremity with Microvascular Free Flaps","volume":"29","author":"R K Khouri","year":"1989","journal-title":"J Trauma Inj Infect Crit Care"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/PRS.0000000000002893","article-title":"Preoperative Platelet Count Predicts Lower Extremity Free Flap Thrombosis","volume":"139","author":"E H Cho","year":"2017","journal-title":"Plast Reconstr Surg"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-017-4146-3","article-title":"Complications and thromboembolic events associated with tamoxifen therapy in\n                    patients with breast cancer undergoing microvascular breast reconstruction: a\n                    systematic review and meta-analysis","volume":"163","author":"R P Parikh","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.889999","volume-title":"Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery\n                    and Anticoagulation","author":"C M Bunch","year":"2022"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1055\/s-0040-1714426","article-title":"Impact of smoking status in free deep inferior epigastric artery perforator flap\n                    breast reconstruction: A multicenter study","volume":"36","author":"L Prantl","year":"2020","journal-title":"J Reconstr Microsurg"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"595e","DOI":"10.1097\/PRS.0000000000000971","article-title":"Evidence to support controversy in microsurgery","volume":"135","author":"K L Fan","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/micr.30156","article-title":"The systematic review and meta-analysis of free flap safety in the elderly\n                    patients","volume":"37","author":"G G \u00dcst\u00fcn","year":"2017","journal-title":"Microsurgery"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"840e","DOI":"10.1097\/PRS.0000000000004990","article-title":"Assessing Age as a Risk Factor for Complications in Autologous Breast\n                    Reconstruction","volume":"142","author":"R Torabi","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1055\/s-0040-1715880","article-title":"Impact of Intraoperative Hypothermia on Microsurgical Free Flap\n                    Reconstructions","volume":"37","author":"N Moellhoff","year":"2021","journal-title":"J Reconstr Microsurg"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/cancers13071545","article-title":"Impact of Goal Directed Therapy in Head and Neck Oncological Surgery with\n                    Microsurgical Reconstruction: Free Flap Viability and Complications","volume":"13","author":"B Tapia","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1055\/s-0039-1687914","article-title":"Perioperative Vasopressor Use in Free Flap Surgery: A Systematic Review and\n                    Meta-Analysis","volume":"35","author":"CS L Goh","year":"2019","journal-title":"J Reconstr Microsurg"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bjps.2022.08.069","article-title":"Vasopressors improve outcomes in autologous free tissue transfer: A systematic\n                    review and meta-analysis","volume":"81","author":"O Noori","year":"2022","journal-title":"J Plast Reconstr Aesthetic Surg"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1055\/s-0038-1648244","article-title":"Effects of Transfusion on Free Flap Survival: Searching for an Optimal\n                    Hemoglobin Threshold for Transfusion","volume":"34","author":"M J Kim","year":"2018","journal-title":"J Reconstr Microsurg"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"001","DOI":"10.1055\/s-0036-1592191","article-title":"Topical Vasodilators in Microsurgery: What Is the Evidence?","volume":"33","author":"J Rinkinen","year":"2016","journal-title":"J Reconstr Microsurg"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1055\/s-0037-1612601","article-title":"Current Practices in the Management of Postoperative Arterial Vasospasm in\n                    Microsurgery","volume":"34","author":"S Turin","year":"2018","journal-title":"J Reconstr Microsurg"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2535-2467.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T22:49:43Z","timestamp":1744670983000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2535-2467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":59,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,4,14]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2535-2467","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"type":"print","value":"0722-1819"},{"type":"electronic","value":"1439-3980"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}