{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:47:53Z","timestamp":1793119673780,"version":"4.5.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"name":"The Second Century Fund (C2F), Chulalongkorn University","id":[{"id":"https:\/\/ror.org\/028wp3y58","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology annual fund, Chulalongkorn University","id":[{"id":"https:\/\/ror.org\/028wp3y58","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The detection of portal venous circulating tumor cells (CTCs) may better reflect vascular metastasis and predict micrometastasis risk than peripheral blood in patients with pancreatic ductal adenocarcinoma (PDAC). We hypothesize that portal CTCs could better represent micrometastasis and can predict survival in PDAC patients.<\/jats:p>\n                  <jats:p>A single-center, prospective cohort study of patients with stage I\u2013III PDAC was conducted. Portal venous blood was obtained via endoscopic ultrasound-guided sampling, and peripheral blood was collected on the same day. CTCs were detected using EpCAM and mucin1 antibodies and reported as cells\/8 mL of blood.<\/jats:p>\n                  <jats:p>Among 35 patients, the portal and peripheral CTC detection rates were 94.3% and 82.9%, respectively. Advanced PDAC with locoregional metastasis had higher portal CTCs than less aggressive disease (P &lt; 0.05), while peripheral CTCs showed no significant differences. During the 50-month follow-up, patients with portal CTCs \u22658 had poorer survival (6.1 vs. 19.0 months; P = 0.001) and patients with peripheral CTCs \u22653 also had poorer survival (4.6 vs. 14.2 months; P = 0.002). In multivariable analysis, both portal CTCs \u22658 and peripheral CTCs \u22653 showed significant adjusted associations with survival (adjusted hazard ratio 3.4 [P = 0.009] and 2.7 [P = 0.02], respectively).<\/jats:p>\n                  <jats:p>Higher CTC counts in both the portal and peripheral systems were significantly associated with poorer survival in stage I\u2013III PDAC; however, only portal CTCs reflected tumor aggression and locoregional metastasis.<\/jats:p>","DOI":"10.1055\/a-2535-7440","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T20:46:22Z","timestamp":1738961182000},"page":"901-909","source":"Crossref","is-referenced-by-count":4,"title":["Portal versus peripheral circulating tumor cells as prognostic biomarkers in patients with stage I\u2013III pancreatic ductal adenocarcinoma"],"prefix":"10.1055","volume":"57","clinical-trial-number":[{"clinical-trial-number":"tctr20210202006","registry":"10.18810\/tctr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-9874","authenticated-orcid":false,"given":"Thaninee","family":"Prasoppokakorn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roongruedee","family":"Chaiteerakij","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Faculty of Medicine, Chuallongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeya","family":"Buntho","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praewphan","family":"Ingrungruanglert","sequence":"additional","affiliation":[{"name":"Center of Excellence in Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Excellence Center for Stem Cell and Cell Therapy, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipan","family":"Israsena","sequence":"additional","affiliation":[{"name":"Center of Excellence in Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Excellence Center for Stem Cell and Cell Therapy, King Chulalongkorn Memorial Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiriyaporn","family":"Rittitid","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Faculty of Medicine, Chuallongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-2794","authenticated-orcid":false,"given":"Phonthep","family":"Angsuwatcharakon","sequence":"additional","affiliation":[{"name":"Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parit","family":"Mekaroonkamol","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-9217","authenticated-orcid":false,"given":"Pradermchai","family":"Kongkam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-6886","authenticated-orcid":false,"given":"Rungsun","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Center of Excellence for Innovation and Endoscopy in Gastrointestinal Oncology, Faculty of Medicine, Chuallongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.3390\/cancers12071930","article-title":"Circulating tumor cell detection technologies and clinical utility: challenges and opportunities","volume":"12","author":"Z Habli","year":"2020","journal-title":"Cancers (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.5306\/wjco.v14.i11.504","article-title":"Circulating tumor cells as potential prognostic biomarkers for early-stage pancreatic cancer: A systematic review and meta-analysis","volume":"14","author":"ZH Zhang","year":"2023","journal-title":"World J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"107223","DOI":"10.18632\/oncotarget.19928","article-title":"Circulating and disseminated tumor cells in pancreatic cancer and their role in patient prognosis: a systematic 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Shmueli","year":"2010","journal-title":"Stat Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e3407","DOI":"10.1097\/MD.0000000000003407","article-title":"A high circulating tumor cell count in portal vein predicts liver metastasis from periampullary or pancreatic cancer: a high portal venous CTC count predicts liver metastases","volume":"95","author":"YW Tien","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.7150\/jca.23989","article-title":"Detection of CTCs in portal vein was associated with intrahepatic metastases and prognosis in patients with advanced pancreatic cancer","volume":"9","author":"X Liu","year":"2018","journal-title":"J Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"7649","DOI":"10.2147\/CMAR.S330473","article-title":"Endoscopic ultrasound-guided acquisition of portal venous circulating tumor cells as a potential diagnostic and prognostic tool for 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Song","year":"2020","journal-title":"Front Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.3390\/cancers13246153","article-title":"Circulating tumor cells enumeration from the portal vein for risk stratification in early pancreatic cancer patients","volume":"13","author":"J Padillo-Ruiz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.4103\/eus.eus_28_18","article-title":"EUS-guided portal vein sampling","volume":"7","author":"CG Chapman","year":"2018","journal-title":"Endosc Ultrasound"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1245\/s10434-020-09518-y","article-title":"Measurement of portal vein blood circulating tumor cells is safe and may correlate with outcomes in resected pancreatic ductal adenocarcinoma","volume":"28","author":"MG White","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/aje\/kws412","article-title":"The table 2 fallacy: presenting and interpreting confounder and modifier coefficients","volume":"177","author":"D Westreich","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1053\/j.gastro.2024.05.032","article-title":"Organoids for functional precision medicine in advanced pancreatic cancer","volume":"167","author":"A Boileve","year":"2024","journal-title":"Gastroenterology"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2535-7440.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T22:31:00Z","timestamp":1753828260000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2535-7440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":20,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,7,29]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2535-7440","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2,7]]},"published":{"date-parts":[[2025,2,7]]}}}