{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:14:21Z","timestamp":1758046461847,"version":"3.44.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although amnioinfusion decreases the rate of uterine atony, its effect on postpartum hemorrhage (PPH) is uncertain. This study aimed to assess whether amnioinfusion reduces the risk of PPH in laboring individuals.<\/jats:p><jats:p>A retrospective study of all laboring singletons at a tertiary center between January 2013 and December 2022 at \u226534 weeks. Individuals with known major fetal anomalies, stillbirths, or missing delivery records were excluded. The primary outcome was PPH. Neonatal and secondary maternal outcomes were also explored. Adjusted odds ratios (aOR) were estimated using multivariable regression models.<\/jats:p><jats:p>Out of 113,816 deliveries during the study period, 83,152 (77.1%) met inclusion criteria, and among them 4,597 (4.03%) had amnioinfusion. Laboring individuals with amnioinfusion were more commonly nulliparous, had more polyhydramnios, oligohydramnios, preeclampsia, gestational diabetes, and fetal growth restriction. Furthermore, individuals with amnioinfusion had a higher rate of labor induction (54.54 vs. 27.8%; p\u2009&lt;\u20090.01) and a higher cesarean rate (36.9 vs. 9.5%; p\u2009&lt;\u20090.01). Following multivariable regression, there was no significant difference in the rate of PPH among individuals who had an amnioinfusion (2.6%) versus those who did not (3.1%; aOR: 0.95, 95% confidence interval [CI]: 0.87, 1.27). The rates of endometritis (aOR: 1.4; 95% CI: 1.04\u20131.89) and postpartum fever (aOR: 1.70; 95% CI: 1.36\u20132.12) were higher in those who had amnioinfusion compared with those that did not.<\/jats:p><jats:p>Among laboring individuals \u2265 34 weeks, intrapartum amnioinfusion was not associated with a reduction in the rate of PPH and was associated with a higher likelihood of infectious morbidity.<\/jats:p>","DOI":"10.1055\/a-2535-8109","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T19:04:33Z","timestamp":1739214273000},"page":"1771-1777","source":"Crossref","is-referenced-by-count":0,"title":["The Yield of Amnioinfusion in the Prevention of Postpartum Hemorrhage"],"prefix":"10.1055","volume":"42","author":[{"given":"Keren","family":"Zloto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sivan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakefet","family":"Yoeli-Ullman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shali","family":"Mazaki-Tovi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneet P.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal Fishel","family":"Bartal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"S 01","key":"ref1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1471-0528.12636","article-title":"Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health","volume":"121","author":"W R Sheldon","year":"2014","journal-title":"BJOG"},{"issue":"02","key":"ref3","first-page":"CD007412","article-title":"Active versus expectant management for women in the third stage of labour","volume":"2","author":"C M Begley","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref5","first-page":"CD000013","article-title":"Amnioinfusion for potential or suspected umbilical cord compression in labour","volume":"1","author":"G J Hofmeyr","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0020-7292(03)00041-9","article-title":"Prophylactic transcervical amnioinfusion in laboring women with oligohydramnios","volume":"81","author":"A F Amin","year":"2003","journal-title":"Int J Gynaecol Obstet"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0301-2115(01)00354-2","article-title":"Meconium-stained amniotic fluid in labor: a randomized trial of prophylactic amniofusion","volume":"99","author":"A Puertas","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00404-009-1196-8","article-title":"Does amnioinfusion reduce caesarean section rate in meconium-stained amniotic fluid","volume":"282","author":"D Choudhary","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S1179","DOI":"10.1016\/j.ajog.2022.07.047","article-title":"Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis","volume":"228","author":"J D Davis","year":"2023","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"51.e1","DOI":"10.1016\/j.ajog.2013.03.011","article-title":"Risk factors for uterine atony\/postpartum hemorrhage requiring treatment after vaginal delivery","volume":"209","author":"L A Wetta","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/AOG.0b013e318242da74","article-title":"Higher-dose oxytocin and hemorrhage after vaginal delivery: a randomized controlled trial","volume":"119","author":"A TN Tita","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"S 03","key":"ref12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/jp.2008.162","article-title":"Meconium aspiration syndrome: historical aspects","volume":"28","author":"A A Fanaroff","year":"2008","journal-title":"J Perinatol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1038\/s41598-023-30839-x","article-title":"Incidence and predictors of severe postpartum hemorrhage after cesarean delivery in South Central Ethiopia: a retrospective cohort study","volume":"13","author":"D Zewdu","year":"2023","journal-title":"Sci Rep"},{"issue":"10","key":"ref14","first-page":"721","article-title":"Amnioinfusion for preventing puerperal infection. 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