{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:26:12Z","timestamp":1783700772649,"version":"3.55.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82273014"],"award-info":[{"award-number":["No. 82273014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"crossref","award":["LGD22H050002"],"award-info":[{"award-number":["LGD22H050002"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the diagnostic accuracy of uroflowmetry in detecting pediatric urethral strictures following tubularized incised plate (TIP) and non-TIP urethroplasty.<\/jats:p><jats:p>A retrospective cohort study was conducted on children who underwent primary hypospadias repairs from June 2016 to June 2023 at our institution. Patients were categorized into the TIP and the non-TIP groups. Urethral calibration and uroflowmetry were used to evaluate urethral patency following urethroplasty. Data on demographic characteristics, perioperative information, uroflowmetry results, urethral calibration outcomes, and postoperative complications were collected.<\/jats:p><jats:p>The relationship between calibration and uroflowmetry and the diagnostic accuracy of uroflowmetry for urethral strictures were analyzed.<\/jats:p><jats:p>A total of 62 cases were included, with 38 in the TIP group and 24 in the non-TIP group. Ten patients were diagnosed with urethral strictures. The maximum urinary flow rate (Qmax) exhibited a higher area under the curve (AUC) than the average urinary flow rate (Qave) in both the TIP and non-TIP groups. The Qmax in the non-TIP group demonstrated a higher AUC than in the TIP group (non-TIP: AUC\u2009=\u20090.94, cutoff\u2009=\u20096.65\u2009ml\/s, sensitivity\u2009=\u2009100%, specificity\u2009=\u200981.0%; TIP: AUC\u2009=\u20090.80, cutoff\u2009=\u20095.75\u2009ml\/s, sensitivity\u2009=\u2009100%, specificity\u2009=\u200958.1%). A significant quadratic correlation was found between Qmax and urethral calibration (non-TIP: C\n                  2\u2009=\u200914.72 * Qmax, R\n                  2\u2009=\u20090.96; TIP: C\n                  2\u2009=\u200914.76 * Qmax, R\n                  2\u2009=\u20090.88). The Qmax nomogram interval\u2009\u2264\u2009\u22123 standard deviation was a significant predictor for non-TIP urethral strictures (kappa\u2009=\u20090.70).<\/jats:p><jats:p>Uroflowmetry, particularly Qmax, shows promise as a noninvasive screening tool for detecting urethral strictures after hypospadias repair. It has high diagnostic accuracy in non-TIP cases but limited utility in TIP cases.<\/jats:p>","DOI":"10.1055\/a-2536-4549","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T20:12:51Z","timestamp":1739304771000},"page":"309-315","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Accuracy of Uroflowmetry for Urethral Strictures in Pediatric Hypospadias: TIP versus Non-TIP Outcomes"],"prefix":"10.1055","volume":"35","author":[{"given":"Wei","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhe","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"61.e1","DOI":"10.1016\/j.jpurol.2020.11.010","article-title":"Identification of risk factors associated with numerous reoperations following primary hypospadias repair","volume":"17","author":"W Ru","year":"2021","journal-title":"J Pediatr Urol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/JU.0000000000003482","article-title":"Urethral Stricture Disease Guideline Amendment (2023)","volume":"210","author":"H Wessells","year":"2023","journal-title":"J Urol"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrurol.2013.164","article-title":"Failed hypospadias in paediatric patients","volume":"10","author":"M Cimador","year":"2013","journal-title":"Nat Rev Urol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s11255-021-02994-5","article-title":"Retrograde urethrography, sonouretrography and magnetic resonance urethrography in evaluation of male urethral strictures. Should the novel methods become the new standard in radiological diagnosis of urethral stricture disease?","volume":"53","author":"F Mikolaj","year":"2021","journal-title":"Int Urol Nephrol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1089\/end.2018.0316","article-title":"Urethral stricture disease: evaluation of the male urethra","volume":"34","author":"J Gelman","year":"2020","journal-title":"J Endourol"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/luts.12499","article-title":"Uroflowmetry parameters in healthy children between 5 and 15\u2009years old","volume":"15","author":"Y D \u00d6zt\u00fcrk","year":"2023","journal-title":"Low Urin Tract Symptoms"},{"key":"ref7","volume-title":"Campbell-Walsh Urology. 11th ed","author":"A J Wein","year":"2016"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.juro.2013.11.098","article-title":"Reduced flow after tubularized 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