{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:34:52Z","timestamp":1789731292450,"version":"4.0.1"},"reference-count":127,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circadian rhythms (CRs) are entrainable endogenous rhythms that respond to external stimuli and regulate physiological functions. The suprachiasmatic nucleus (SCN) in the hypothalamus is the mammalian master clock that synchronizes all other tissue-specific peripheral clocks, primarily through gamma-aminobutyric acid (GABA) and vasoactive intestinal polypeptide (VIP). The SCN follows Earth's 24-hour cycle by light entrainment through the retinohypothalamic tract. At the cellular level, the core clock genes CLOCK, BMAL1, PER1\u2013PER3, CRY1, and CRY2 regulate CRs in a negative feedback loop. The circadian disruption of the sleep\u2013wake cycle manifests in at least six distinct clinical conditions. These are the circadian rhythm sleep\u2013wake disorders (CRSWDs). Their diagnosis is made by history, sleep diaries, and actigraphy. Treatment involves a combination of timed light exposure, melatonin\/melatonin agonists, and behavioral interventions. In addition, CR disturbances and subsequent misalignment can increase the risk of a variety of illnesses. These include infertility and menstrual irregularities as well as diabetes, obesity, fatty liver disease, and other metabolic syndromes. In addition, a disruption in the gut microbiome creates a proinflammatory environment. CR disturbances increase the risk for mood disorders, hence the utility of light-based therapies in depression. People with neurodegenerative disorders demonstrate significant disturbances in their CRs, and in their sleep\u2013wake cycles. Circadian realignment therapies can also help decrease the symptomatic burden of these disorders. Certain epilepsy syndromes, such as juvenile myoclonic epilepsy (JME), have a circadian pattern of seizures. Circadian disturbances in epilepsy can be both the consequence and cause for breakthrough seizures. The immune system has its own CR. Disturbances in these due to shift work, for instance, can increase the risk of infections. CR disturbances can also increase the risk of cancer by impacting DNA repair, apoptosis, immune surveillance, and cell cycle regulation. Moreover, the timing of chemotherapeutic agents has been shown to increase their therapeutic impact in certain cancers.<\/jats:p>","DOI":"10.1055\/a-2538-3259","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:19:51Z","timestamp":1739837991000},"page":"317-332","source":"Crossref","is-referenced-by-count":23,"title":["Clinical Chronobiology: Circadian Rhythms in Health and Disease"],"prefix":"10.1055","volume":"45","author":[{"given":"Shizuka","family":"Tomatsu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabra M.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, 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Genet"},{"issue":"6315","key":"ref3","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"S Panda","year":"2016","journal-title":"Science"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ncl.2019.03.001","article-title":"Circadian neurobiology and the physiologic regulation of sleep and wakefulness","volume":"37","author":"W J Schwartz","year":"2019","journal-title":"Neurol Clin"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Y Leng","year":"2019","journal-title":"Lancet Neurol"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cmet.2014.11.008","article-title":"Diet and feeding pattern affect the diurnal dynamics of the gut microbiome","volume":"20","author":"A Zarrinpar","year":"2014","journal-title":"Cell Metab"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ncl.2019.05.002","article-title":"Genetics of circadian rhythms","volume":"37","author":"M H Vitaterna","year":"2019","journal-title":"Neurol Clin"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuron.2023.09.023","article-title":"Circadian rhythms and mood disorders: time to see the light","volume":"112","author":"H K Dollish","year":"2024","journal-title":"Neuron"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"bqaa167","DOI":"10.1210\/endocr\/bqaa167","article-title":"Circadian rhythms and the gastrointestinal tract: relationship to metabolism and gut hormones","volume":"161","author":"A Martchenko","year":"2020","journal-title":"Endocrinology"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13311-021-01031-8","article-title":"Circadian rhythm sleep-wake disorders: a contemporary review of neurobiology, treatment, and dysregulation in neurodegenerative disease","volume":"18","author":"T A Steele","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"04","key":"ref11","first-page":"988","article-title":"Circadian rhythm sleep-wake disorders","volume":"26","author":"P C Zee","year":"2020","journal-title":"Continuum (Minneap Minn)"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jsmc.2015.08.003","article-title":"Neurobiology of circadian rhythm regulation","volume":"10","author":"A M Rosenwasser","year":"2015","journal-title":"Sleep Med Clin"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12915-018-0623-3","article-title":"Circadian oscillator proteins across the kingdoms of life: structural aspects","volume":"17","author":"R Saini","year":"2019","journal-title":"BMC Biol"},{"issue":"02","key":"ref14","first-page":"251","article-title":"Effects of BMAL1 manipulation on the brain's master circadian clock and behavior","volume":"92","author":"S N Haque","year":"2019","journal-title":"Yale J Biol Med"},{"issue":"6105","key":"ref15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.1226339","article-title":"Transcriptional architecture and chromatin landscape of the core circadian clock in mammals","volume":"338","author":"N Koike","year":"2012","journal-title":"Science"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13073-019-0704-0","article-title":"Genomics of circadian rhythms in health and disease","volume":"11","author":"F Rijo-Ferreira","year":"2019","journal-title":"Genome Med"},{"key":"ref17","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine (AASM)","year":"2023","edition":"3rd Edition, Te"},{"key":"ref18","volume-title":"Sleep Medicine Pearls","author":"R B Berry","year":"2015","edition":"3rd ed."},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/074873049701200614","article-title":"Exogenous melatonin's phase-shifting effects on the endogenous melatonin profile in sighted humans: a brief review and critique of the literature","volume":"12","author":"A J Lewy","year":"1997","journal-title":"J Biol Rhythms"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1210\/jc.2009-2590","article-title":"Human phase response curves to three days of daily melatonin: 0.5\u2009mg versus 3.0\u2009mg","volume":"95","author":"H J Burgess","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/07420529209064550","article-title":"Melatonin shifts human circadian rhythms according to a phase-response curve","volume":"9","author":"A J Lewy","year":"1992","journal-title":"Chronobiol Int"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"zsaa281","DOI":"10.1093\/sleep\/zsaa281","article-title":"Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities","volume":"44","author":"J F Duffy","year":"2021","journal-title":"Sleep"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.5664\/jcsm.5100","article-title":"Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015: an American Academy of Sleep Medicine clinical practice guideline","volume":"11","author":"R R Auger","year":"2015","journal-title":"J Clin Sleep Med"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1017\/S1092852900016576","article-title":"Delayed sleep phase in severe obsessive-compulsive disorder: a systematic case-report survey","volume":"13","author":"S Mukhopadhyay","year":"2008","journal-title":"CNS Spectr"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jad.2012.06.006","article-title":"Delayed sleep phase in young people with unipolar or bipolar affective disorders","volume":"145","author":"R Robillard","year":"2013","journal-title":"J Affect Disord"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s41105-018-0188-0","article-title":"ADHD symptoms in adults with delayed sleep phase disorder","volume":"17","author":"M A Snitselaar","year":"2019","journal-title":"Sleep Biol Rhythms"},{"issue":"02","key":"ref28","first-page":"108","article-title":"A prospective study of delayed sleep phase syndrome in patients with severe resistant obsessive-compulsive disorder","volume":"6","author":"J Turner","year":"2007","journal-title":"World Psychiatry"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2017.03.027","article-title":"Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder","volume":"169","author":"A Patke","year":"2017","journal-title":"Cell"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"zsaa132","DOI":"10.1093\/sleep\/zsaa132","article-title":"Circadian tau differences and rhythm associations in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder","volume":"44","author":"G Micic","year":"2021","journal-title":"Sleep"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"zsad222","DOI":"10.1093\/sleep\/zsad222","article-title":"What's in a name? delayed by any other name is still a circadian disorder: a call for improved nomenclature for delayed sleep-wake phase disorder subtypes","volume":"46","author":"S M Abbott","year":"2023","journal-title":"Sleep"},{"issue":"09","key":"ref32","doi-asserted-by":"crossref","first-page":"e0204621","DOI":"10.1371\/journal.pone.0204621","article-title":"The pupillary light reflex distinguishes between circadian and non-circadian delayed sleep phase disorder (DSPD) phenotypes in young adults","volume":"13","author":"E M McGlashan","year":"2018","journal-title":"PLoS One"},{"issue":"5423","key":"ref33","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1126\/science.284.5423.2177","article-title":"Stability, precision, and near-24-hour period of the human circadian pacemaker","volume":"284","author":"C A Czeisler","year":"1999","journal-title":"Science"},{"issue":"09","key":"ref34","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/sleep\/30.9.1225","article-title":"Delayed sleep phase disorder in temporal isolation","volume":"30","author":"S S Campbell","year":"2007","journal-title":"Sleep"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/0748730416650069","article-title":"Circadian melatonin and temperature taus in delayed sleep-wake phase disorder and non-24-hour sleep-wake rhythm disorder patients: an ultradian constant routine study","volume":"31","author":"G Micic","year":"2016","journal-title":"J Biol Rhythms"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.sleep.2016.04.002","article-title":"Personality differences in patients with delayed sleep-wake phase disorder and non-24-h sleep-wake rhythm disorder relative to healthy sleepers","volume":"30","author":"G Micic","year":"2017","journal-title":"Sleep Med"},{"issue":"06","key":"ref37","doi-asserted-by":"crossref","first-page":"e1002587","DOI":"10.1371\/journal.pmed.1002587","article-title":"Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: a double-blind, randomised clinical trial","volume":"15","author":"T L Sletten","year":"2018","journal-title":"PLoS Med"},{"issue":"05","key":"ref38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamaneurol.2017.4719","article-title":"Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease","volume":"75","author":"E S Musiek","year":"2018","journal-title":"JAMA Neurol"},{"issue":"09","key":"ref39","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/12502","article-title":"Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans","volume":"5","author":"C R Jones","year":"1999","journal-title":"Nat Med"},{"issue":"5506","key":"ref40","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.1057499","article-title":"An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome","volume":"291","author":"K L Toh","year":"2001","journal-title":"Science"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tig.2012.08.002","article-title":"Genetic insights on sleep schedules: this time, it's PERsonal","volume":"28","author":"S Y Chong","year":"2012","journal-title":"Trends Genet"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1880-6805-31-7","article-title":"Pathophysiology and pathogenesis of circadian rhythm sleep disorders","volume":"31","author":"A Hida","year":"2012","journal-title":"J Physiol Anthropol"},{"key":"ref43","first-page":"109","volume-title":"Advanced sleep-wake disorder","author":"E K Lee","year":"2020"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s43042-021-00177-6","article-title":"PERIOD3 gene P415A\/H417R polymorphism-linked familial advanced sleep phase","volume":"22","author":"C E Okechukwu","year":"2021","journal-title":"Egypt J Med Hum Genet"},{"issue":"14","key":"ref45","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1074\/jbc.M111.224014","article-title":"Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability","volume":"286","author":"N P Shanware","year":"2011","journal-title":"J Biol Chem"},{"issue":"7033","key":"ref46","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature03453","article-title":"Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome","volume":"434","author":"Y Xu","year":"2005","journal-title":"Nature"},{"issue":"07","key":"ref47","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/archneur.58.7.1089","article-title":"Familial advanced sleep phase syndrome","volume":"58","author":"K J Reid","year":"2001","journal-title":"Arch Neurol"},{"issue":"04","key":"ref48","first-page":"1149","article-title":"Circadian rhythm sleep-wake disorders","volume":"29","author":"F B Consens","year":"2023","journal-title":"Continuum (Minneap Minn)"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/07420528.2014.885036","article-title":"Identifying advanced and delayed sleep phase disorders in the general population: a national survey of New Zealand adults","volume":"31","author":"S J Paine","year":"2014","journal-title":"Chronobiol Int"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"zsz148","DOI":"10.1093\/sleep\/zsz148","article-title":"Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep-wake phase disorder in a sleep clinic population","volume":"42","author":"B J Curtis","year":"2019","journal-title":"Sleep"},{"issue":"05","key":"ref51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/sleep\/16.5.436","article-title":"The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs","volume":"16","author":"L Lack","year":"1993","journal-title":"Sleep"},{"issue":"08","key":"ref52","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1532-5415.1993.tb06179.x","article-title":"Alleviation of sleep maintenance insomnia with timed exposure to bright light","volume":"41","author":"S S Campbell","year":"1993","journal-title":"J Am Geriatr Soc"},{"issue":"06","key":"ref53","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3171\/jns.2003.98.6.1208","article-title":"The efficacy and safety of aprotinin for hemostasis during intracranial surgery","volume":"98","author":"J D Palmer","year":"2003","journal-title":"J Neurosurg"},{"issue":"04","key":"ref54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1532-5415.2002.50154.x","article-title":"Failure of timed bright light exposure to alleviate age-related sleep maintenance insomnia","volume":"50","author":"A G Suhner","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"07","key":"ref55","first-page":"923","article-title":"Melantonin for the treatment of advanced sleep phase disorder","volume":"31","author":"P C Zee","year":"2008","journal-title":"Sleep"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jsmc.2015.08.005","article-title":"Irregular sleep-wake rhythm disorder","volume":"10","author":"S M Abbott","year":"2015","journal-title":"Sleep Med Clin"},{"issue":"02","key":"ref57","first-page":"295","article-title":"Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin","volume":"76","author":"D R Weaver","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0887-8994(00)00161-2","article-title":"Melatonin improves sleep-wake patterns in psychomotor retarded children","volume":"23","author":"G Pillar","year":"2000","journal-title":"Pediatr Neurol"},{"key":"ref59","first-page":"617","volume-title":"Shift-work disorder and treatment","author":"B Bjorvatn","year":"2023"},{"issue":"22","key":"ref60","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/jama.299.22.2642","article-title":"Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial","volume":"299","author":"R F Riemersma-van der Lek","year":"2008","journal-title":"JAMA"},{"key":"ref61","first-page":"1051","article-title":"Circadian rhythm sleep-wake disorders","volume":"23","author":"M Pavlova","year":"2017","journal-title":"Continuum (Minneap Minn)"},{"issue":"05","key":"ref62","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/sleep\/22.5.616","article-title":"Sleep and activity rhythms are related to circadian phase in the blind","volume":"22","author":"S W Lockley","year":"1999","journal-title":"Sleep"},{"issue":"04","key":"ref63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jsmc.2015.07.006","article-title":"Non-24-hour sleep-wake rhythm disorder in sighted and blind patients","volume":"10","author":"M Uchiyama","year":"2015","journal-title":"Sleep Med Clin"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/0748730414536852","article-title":"Circadian rhythm disorders and melatonin production in 127 blind women with and without light perception","volume":"29","author":"E E Flynn-Evans","year":"2014","journal-title":"J Biol Rhythms"},{"issue":"11","key":"ref65","first-page":"3763","article-title":"Relationship between melatonin rhythms and visual loss in the blind","volume":"82","author":"S W Lockley","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"01","key":"ref66","first-page":"127","article-title":"Circadian rhythm abnormalities in totally blind people: incidence and clinical significance","volume":"75","author":"R L Sack","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"02","key":"ref67","doi-asserted-by":"crossref","first-page":"zsaa184","DOI":"10.1093\/sleep\/zsaa184","article-title":"Melanopsin-dependent phototransduction is impaired in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder","volume":"44","author":"S M Abbott","year":"2021","journal-title":"Sleep"},{"key":"ref68","first-page":"624","volume-title":"Non-24-h sleep-wake disorder in sighted and blind patients","author":"S W Lockley","year":"2023"},{"issue":"04","key":"ref69","doi-asserted-by":"crossref","first-page":"603","DOI":"10.5664\/jcsm.7054","article-title":"Diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder","volume":"14","author":"R G Malkani","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"1693","key":"ref70","first-page":"2485","article-title":"Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses","volume":"277","author":"S Tsujimura","year":"2010","journal-title":"Proc Biol Sci"},{"issue":"06","key":"ref71","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1167\/iovs.14-16233","article-title":"The post-illumination pupil response (PIPR)","volume":"56","author":"P Adhikari","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"01","key":"ref72","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/comp.2002.29849","article-title":"Time zone change and major psychiatric morbidity: the results of a 6-year study in Jerusalem","volume":"43","author":"G Katz","year":"2002","journal-title":"Compr Psychiatry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tmaid.2018.05.008","article-title":"Jetlag related sleep problems and their management: a review","volume":"24","author":"C Cingi","year":"2018","journal-title":"Travel Med Infect Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tmaid.2007.12.002","article-title":"Jet lag: therapeutic use of melatonin and possible application of melatonin analogs","volume":"6","author":"V Srinivasan","year":"2008","journal-title":"Travel Med Infect Dis"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jsmc.2009.02.006","article-title":"How to travel the world without jet lag","volume":"4","author":"C I Eastman","year":"2009","journal-title":"Sleep Med Clin"},{"key":"ref76","first-page":"632","volume-title":"Jet lag type","author":"D Blum","year":"2023"},{"issue":"03","key":"ref77","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ncl.2019.03.003","article-title":"Shift work disorder","volume":"37","author":"P Cheng","year":"2019","journal-title":"Neurol Clin"},{"issue":"05","key":"ref78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/smrv.2001.0215","article-title":"Bright light, dark and melatonin can promote circadian adaptation in night shift workers","volume":"6","author":"H J Burgess","year":"2002","journal-title":"Sleep Med Rev"},{"issue":"11","key":"ref79","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/sleep\/32.11.1481","article-title":"A compromise circadian phase position for permanent night work improves mood, fatigue, and performance","volume":"32","author":"M R Smith","year":"2009","journal-title":"Sleep"},{"key":"ref80","first-page":"636","volume-title":"Shift work disorder and treatment","author":"C Sagong","year":"2023"},{"issue":"04","key":"ref81","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1046\/j.1365-2869.1998.00121.x","article-title":"Promoting alertness with a short nap during a night shift","volume":"7","author":"M Sallinen","year":"1998","journal-title":"J Sleep Res"},{"issue":"01","key":"ref82","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/sleep\/29.1.39","article-title":"Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work","volume":"29","author":"P K Schweitzer","year":"2006","journal-title":"Sleep"},{"issue":"49","key":"ref83","doi-asserted-by":"crossref","first-page":"eabg9910","DOI":"10.1126\/sciadv.abg9910","article-title":"Daytime eating prevents internal circadian misalignment and glucose intolerance in night work","volume":"7","author":"S L Chellappa","year":"2021","journal-title":"Sci Adv"},{"issue":"01","key":"ref84","doi-asserted-by":"crossref","first-page":"2313769","DOI":"10.1080\/19490976.2024.2313769","article-title":"Gut microbiota regulates host melatonin production through epithelial cell MyD88","volume":"16","author":"B Liu","year":"2024","journal-title":"Gut Microbes"},{"issue":"04","key":"ref85","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41574-023-00927-z","article-title":"The intersection between ghrelin, metabolism and circadian rhythms","volume":"20","author":"S S Kulkarni","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"06","key":"ref86","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/MED.0000000000000511","article-title":"Impact of circadian rhythms on female reproduction and infertility treatment success","volume":"26","author":"J Mills","year":"2019","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"05","key":"ref87","doi-asserted-by":"crossref","first-page":"e37668","DOI":"10.1371\/journal.pone.0037668","article-title":"Environmental perturbation of the circadian clock disrupts pregnancy in the mouse","volume":"7","author":"K C Summa","year":"2012","journal-title":"PLoS One"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.smrv.2014.10.005","article-title":"Sleep, sleep disturbance, and fertility in women","volume":"22","author":"J D Kloss","year":"2015","journal-title":"Sleep Med Rev"},{"issue":"09","key":"ref89","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.sleep.2012.06.024","article-title":"Systematic evaluation of Axis-I DSM diagnoses in delayed sleep phase disorder and evening-type circadian preference","volume":"13","author":"K J Reid","year":"2012","journal-title":"Sleep Med"},{"issue":"01","key":"ref90","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/da.22422","article-title":"Chronotype associations with depression and anxiety disorders in a large cohort study","volume":"33","author":"N Antypa","year":"2016","journal-title":"Depress Anxiety"},{"issue":"08","key":"ref91","first-page":"1045","article-title":"Associations between chronotype, morbidity and mortality in the UK Biobank cohort","volume":"35","author":"K L Knutson","year":"2018","journal-title":"Chronobiol Int"},{"issue":"06","key":"ref92","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/depr.3050010602","article-title":"Biological rhythms and depression: the role of zeitgebers and zeitstorers","volume":"1","author":"C L Ehlers","year":"1993","journal-title":"Depression"},{"issue":"01","key":"ref93","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0165-1781(91)90110-B","article-title":"Diurnal variation of symptoms in seasonal affective disorder","volume":"37","author":"P Graw","year":"1991","journal-title":"Psychiatry Res"},{"issue":"04","key":"ref94","first-page":"705","article-title":"Light therapy in patients with rapid cycling bipolar disorder: preliminary results","volume":"31","author":"E Leibenluft","year":"1995","journal-title":"Psychopharmacol Bull"},{"issue":"02","key":"ref95","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-1781(90)90065-D","article-title":"Is seasonal affective disorder a variant of atypical depression? Differential response to light therapy","volume":"33","author":"J W Stewart","year":"1990","journal-title":"Psychiatry Res"},{"issue":"08","key":"ref96","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0006-3223(98)00289-3","article-title":"A rapid-cycling bipolar patient treated with long nights, bedrest, and light","volume":"45","author":"A Wirz-Justice","year":"1999","journal-title":"Biol Psychiatry"},{"issue":"09","key":"ref97","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/archpsyc.62.9.996","article-title":"Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder","volume":"62","author":"E Frank","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"ref98","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/archpsyc.1988.01800340076012","article-title":"Social zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression","volume":"45","author":"C L Ehlers","year":"1988","journal-title":"Arch Gen Psychiatry"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI90328","article-title":"The aging clock: circadian rhythms and later life","volume":"127","author":"S Hood","year":"2017","journal-title":"J Clin Invest"},{"issue":"11","key":"ref100","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1136\/bjo.2008.141747","article-title":"Circadian photoreception: ageing and the eye's important role in systemic health","volume":"92","author":"P L Turner","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"04","key":"ref101","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jamaneurol.2013.6239","article-title":"Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease","volume":"71","author":"A Videnovic","year":"2014","journal-title":"JAMA Neurol"},{"issue":"01","key":"ref102","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1755-3768.2011.02291.x","article-title":"Short wavelength light filtering by the natural human lens and IOLs\u2014implications for entrainment of circadian rhythm","volume":"91","author":"A E Br\u00f8ndsted","year":"2013","journal-title":"Acta Ophthalmol"},{"issue":"01","key":"ref103","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-200478","article-title":"Fiat lux: the light became therapy. An overview on the bright light therapy in Alzheimer's disease sleep disorders","volume":"77","author":"I Roccaro","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"04","key":"ref104","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/07420529908998724","article-title":"Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods","volume":"16","author":"E J Van Someren","year":"1999","journal-title":"Chronobiol Int"},{"issue":"12","key":"ref105","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s00415-009-5196-1","article-title":"Delayed onset of the diurnal melatonin rise in patients with Huntington's disease","volume":"256","author":"N A Aziz","year":"2009","journal-title":"J Neurol"},{"issue":"01","key":"ref106","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease","volume":"25","author":"A J Morton","year":"2005","journal-title":"J Neurosci"},{"issue":"10","key":"ref107","doi-asserted-by":"crossref","first-page":"zsz154","DOI":"10.1093\/sleep\/zsz154","article-title":"Sleep in Huntington's disease: a systematic review and meta-analysis of polysomongraphic findings","volume":"42","author":"Y Zhang","year":"2019","journal-title":"Sleep"},{"issue":"01","key":"ref108","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/07420528.2020.1842752","article-title":"Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington's disease","volume":"38","author":"M Khyati","year":"2021","journal-title":"Chronobiol Int"},{"issue":"S 01","key":"ref109","first-page":"S49","article-title":"Circadian\/multidien molecular oscillations and rhythmicity of epilepsy (MORE)","volume":"62","author":"C Bernard","year":"2021","journal-title":"Epilepsia"},{"issue":"04","key":"ref110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jamaneurol.2020.5370","article-title":"Seizure cycles in focal epilepsy","volume":"78","author":"M G Leguia","year":"2021","journal-title":"JAMA Neurol"},{"issue":"02","key":"ref111","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/1535759721989674","article-title":"Untangling a Web: basic mechanisms of the complex interactions between sleep, circadian rhythms, and epilepsy","volume":"21","author":"R K Maganti","year":"2021","journal-title":"Epilepsy Curr"},{"issue":"12","key":"ref112","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S1474-4422(18)30335-1","article-title":"Circadian rhythm and epilepsy","volume":"17","author":"S Khan","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.yebeh.2017.11.008","article-title":"Juvenile myoclonic epilepsy and sleep","volume":"80","author":"L Xu","year":"2018","journal-title":"Epilepsy Behav"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"941354","DOI":"10.1155\/2015\/941354","article-title":"Chronotypes in patients with epilepsy: does the type of epilepsy make a difference?","volume":"2015","author":"H Kendis","year":"2015","journal-title":"Behav Neurol"},{"issue":"02","key":"ref115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/joim.13795","article-title":"Circadian and ultradian rhythms: clinical implications","volume":"296","author":"S L Lightman","year":"2024","journal-title":"J Intern Med"},{"issue":"02","key":"ref116","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00281-021-00889-2","article-title":"Glucocorticoid circadian rhythms in immune function","volume":"44","author":"I Olejniczak","year":"2022","journal-title":"Semin Immunopathol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1000951","DOI":"10.3389\/fimmu.2022.1000951","article-title":"Potential effects of shift work on skin autoimmune diseases","volume":"13","author":"S Stenger","year":"2023","journal-title":"Front Immunol"},{"issue":"02","key":"ref118","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s40675-017-0071-6","article-title":"Shift work: disrupted circadian rhythms and sleep\u2014implications for health and well-being","volume":"3","author":"S M James","year":"2017","journal-title":"Curr Sleep Med Rep"},{"issue":"11","key":"ref119","doi-asserted-by":"crossref","first-page":"e167339","DOI":"10.1172\/JCI167339","article-title":"Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients","volume":"133","author":"G Hazan","year":"2023","journal-title":"J Clin Invest"},{"issue":"01","key":"ref120","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41467-023-35979-2","article-title":"Influence of circadian clocks on adaptive immunity and vaccination responses","volume":"14","author":"L M Ince","year":"2023","journal-title":"Nat Commun"},{"issue":"03","key":"ref121","doi-asserted-by":"crossref","first-page":"e1008514","DOI":"10.1371\/journal.pcbi.1008514","article-title":"Modeling the circadian regulation of the immune system: sexually dimorphic effects of shift work","volume":"17","author":"S MC Abo","year":"2021","journal-title":"PLOS Comput Biol"},{"issue":"01","key":"ref122","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13045-022-01238-y","article-title":"Circadian rhythms and cancers: the intrinsic links and therapeutic potentials","volume":"15","author":"L Zhou","year":"2022","journal-title":"J Hematol Oncol"},{"issue":"06","key":"ref123","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/07487304211044301","article-title":"Circadian rhythms, disease and chronotherapy","volume":"36","author":"Y Lee","year":"2021","journal-title":"J Biol Rhythms"},{"issue":"9079","key":"ref124","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0140-6736(97)03358-8","article-title":"Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer","volume":"350","author":"F L\u00e9vi","year":"1997","journal-title":"Lancet"},{"issue":"04","key":"ref125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00001813-199904000-00006","article-title":"Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion","volume":"10","author":"C Focan","year":"1999","journal-title":"Anticancer Drugs"},{"issue":"05","key":"ref126","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11095-020-02828-6","article-title":"Phase I pharmacological study of continuous chronomodulated capecitabine treatment","volume":"37","author":"J Roosendaal","year":"2020","journal-title":"Pharm Res"},{"issue":"12","key":"ref127","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1158\/1078-0432.CCR-18-3185","article-title":"Phase 1 open-label, multicenter study of first-in-class ROR\u03b3 agonist LYC-55716 (cintirorgon): safety, tolerability, and preliminary evidence of antitumor activity","volume":"25","author":"D Mahalingam","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"01","key":"ref128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10637-018-0610-0","article-title":"Phase Ib study of pevonedistat, a NEDD8-activating enzyme inhibitor, in combination with docetaxel, carboplatin and paclitaxel, or 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