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Emerging therapies targeting glutamate and adenosine receptors, alongside established dopamine agonists and \u03b12\u03b4 ligands, offer promising avenues for treatment.<\/jats:p>","DOI":"10.1055\/a-2538-3300","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:57:56Z","timestamp":1741741076000},"page":"368-382","source":"Crossref","is-referenced-by-count":4,"title":["Restless Legs Syndrome: Neurochemistry and Therapy"],"prefix":"10.1055","volume":"45","author":[{"given":"David","family":"Anguizola","sequence":"additional","affiliation":[{"name":"Instituto Europeo del Sue\u00f1o, Panam\u00e1, Panam\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Garcia Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Sleep Research Institute, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Moncada","sequence":"additional","affiliation":[{"name":"Sleep Research 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