{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:29:56Z","timestamp":1744172996941,"version":"3.40.3"},"reference-count":67,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>In den letzten Jahrzehnten wurden erhebliche Fortschritte in der Behandlung des Rektumkarzinoms erzielt, die zu einer Reduktion der Lokalrezidivrate und einer Verbesserung der Prognose gef\u00fchrt haben. Die noch aktuelle S3-Leitlinie zum kolorektalen Karzinom empfiehlt die neoadjuvante Therapie bei Tumoren des mittleren und unteren Rektums im UICC-Stadium II und III. Die prim\u00e4re Operation wird weiterhin bei UICC-I-Tumoren empfohlen, wobei f\u00fcr bestimmte Subgruppen, wie cT1\/2-Tumoren mit fraglichem Lymphknotenbefall, Ausnahmen diskutiert werden. Aktuelle Studien konzentrieren sich auf multimodale Therapiekonzepte, insbesondere auf die total neoadjuvante Therapie (TNT), die in mehreren Phase-II- und Phase-III-Studien untersucht wurde. Dar\u00fcber hinaus werden Therapien mit selektivem Verzicht auf eine neoadjuvante Bestrahlung sowie organerhaltende Ans\u00e4tze untersucht. Die vorliegende \u00dcbersichtsarbeit gibt einen umfassenden \u00dcberblick \u00fcber die aktuelle Evidenzlage zur neoadjuvanten\n      Therapie des Rektumkarzinoms, beleuchtet neue multimodale Therapieans\u00e4tze und diskutiert zuk\u00fcnftige Herausforderungen und M\u00f6glichkeiten, um die Therapie stadiengerecht zu optimieren und Patienten individuell bestm\u00f6glich zu behandeln.<\/jats:p>","DOI":"10.1055\/a-2539-5533","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:15:41Z","timestamp":1744154141000},"page":"140-150","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvante Therapie beim Rektumkarzinom \u2013 f\u00fcr wen, wie und mit welchem Ziel?"],"prefix":"10.1055","volume":"150","author":[{"given":"Franziska","family":"Willis","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg, Standort 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