{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T23:10:08Z","timestamp":1747350608009,"version":"3.40.5"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inguinal sentinel lymph node dissection has been shown to be safe in early vulvar cancer in several studies and is considered or even recommended in many guidelines. The prognosis of inguinal recurrence is often poor and associated with significant mortality. To ensure an acceptably low false-negative rate and recurrence, vulvar sentinel lymph node dissection should only be performed using high-quality standards. This retrospective study aims to investigate the incidence of isolated groin recurrence in daily practice in six large cancer centers in Germany.<\/jats:p><jats:p>We identified all patients with early vulvar cancer in 2009\u20132015 who underwent inguinal sentinel lymphonodectomy and presented with node-negative final histologic results. Patient details regarding disease stage, sentinel procedure, and follow-up were examined using local cancer databases and patient registries.<\/jats:p><jats:p>A total of 414 patients with available follow-up data were found, with a mean follow-up time of 38.4 months. The mean tumor size, measured in the dermal plane before surgery, was 40.0\u00a0mm, with a median tumor size of 36\u00a0mm. Isolated groin recurrence was found in 13 of 414 cases, leading to an isolated groin recurrence rate of 3.1%. The mean time to isolated groin recurrence was 17.7 months. There was no statistically significant association of any of the different quality requirements (tumor size &lt;\u00a04\u00a0cm, unifocal tumor, histologic ultra-staging, and preoperative exclusion of suspicious groins) with isolated groin recurrence.<\/jats:p><jats:p>Sentinel lymphadenectomy in vulvar cancer is a safe procedure in daily practice. The requirements of the cancer guidelines (unifocal tumor, \u2264\u00a04\u00a0cm, histologic ultrastaging, and exclusion of suspicious groins preoperatively) should be followed to ensure a low isolated groin recurrence rate. However, in this study, we could not find any difference between the patients who fulfilled the guideline requirements and those who did not.<\/jats:p>","DOI":"10.1055\/a-2541-2191","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:24:21Z","timestamp":1742955861000},"page":"533-540","source":"Crossref","is-referenced-by-count":0,"title":["Sentinel Lymphonodectomy in Early Vulvar Cancer in Daily Practice: a Multicenter Experience from Germany"],"prefix":"10.1055","volume":"85","author":[{"given":"Philipp","family":"Soergel","sequence":"additional","affiliation":[{"name":"University Women\u2019s Hospital, Johannes Wesling Klinikum Minden, Ruhr University Clinic, Minden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hempel","sequence":"additional","affiliation":[{"name":"University Women\u2019s Hospital, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gallwas","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University of Munich, Munich, Germany"},{"name":"Department of Gynecology and Obstetrics, University Hospital G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dannecker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Augsburg, Augsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn","family":"Woelber","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf and Colposcopy Center at the Jerusalem Hospital, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruediger","family":"Klapdor","sequence":"additional","affiliation":[{"name":"University Women\u2019s Hospital, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer","family":"Hantschmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Alt\u00f6tting Hospital, Alt\u00f6tting, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk M.","family":"Forner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cologne-Kalk Hospital, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gass","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-EMN, Friedrich Alexander University of Erlangen\u2013Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Hampl","sequence":"additional","affiliation":[{"name":"University Women\u2019s Hospital, University Hospital of D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the AGO Komission Vulva\/Vagina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ygyno.2008.01.041","article-title":"New aspects of vulvar cancer: Changes in localization and age of onset","volume":"109","author":"M Hampl","year":"2008","journal-title":"Gynecol Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"RL Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju426","article-title":"Adjuvant therapy in lymph node-positive vulvar cancer: The AGO-CaRE-1 study","volume":"107","author":"S Mahner","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/bjc.2011.407","article-title":"Risk factors for short- and long-term complications after groin surgery in vulvar cancer","volume":"105","author":"F Hinten","year":"2011","journal-title":"Br J Cancer"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.ygyno.2008.08.007","article-title":"Validation of the accuracy of the sentinel lymph node procedure in patients with vulvar cancer: Results of a multicenter study in Germany","volume":"111","author":"M Hampl","year":"2008","journal-title":"Gynecol Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1200\/JCO.2007.14.0566","article-title":"Sentinel node dissection is safe in the treatment of early-stage vulvar cancer","volume":"26","author":"AG Van der Zee","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ygyno.2015.09.077","article-title":"Sentinel nodes in vulvar cancer: Long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I","volume":"140","author":"NC Te Grootenhuis","year":"2016","journal-title":"Gynecol Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1055\/s-0042-103728","article-title":"Diagnosis, therapy, and follow-up care of vulvar cancer and its precursors. 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An analysis of the AGO-CaRE-1 multicenter study","volume":"154","author":"R Klapdor","year":"2019","journal-title":"Gynecol Oncol"}],"container-title":["Geburtshilfe und Frauenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2541-2191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T22:34:15Z","timestamp":1747348455000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2541-2191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":13,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,5,15]]},"published-print":{"date-parts":[[2025,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2541-2191","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0016-5751","1438-8804"],"issn-type":[{"type":"print","value":"0016-5751"},{"type":"electronic","value":"1438-8804"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}