{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:34:06Z","timestamp":1768487646472,"version":"3.49.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonsurgical rhinoplasty has emerged as a preferred nasal aesthetic treatment due to its safety, predictability, and high patient satisfaction. It utilizes dermal fillers, primarily hyaluronic acid (HA), to enhance nasal profiles and correct defects. However, limited data exist on the effects of HA-containing dermal fillers on nasal cartilage. This study aimed to evaluate these effects histopathologically. Sixteen New Zealand white rabbits were divided into two groups (A and B). Group A's right lateral cartilages (AR) received 0.1\u2009mL of VYC-20L filler, while the left (AL) received isotonic saline. Group B's right lateral cartilages (BR) received 0.1\u2009mL of VYC-25L filler, with the left (BL) serving as the control. After 90 days, the rabbits were sacrificed, and cartilage samples were analyzed histopathologically for cartilage thickness, chondrocyte nucleus loss, inflammation, fibrosis, giant cells, granulation tissue, abscess, and necrosis. Statistical significance was set at p\u2009&lt;\u20090.05. Significant differences were found between groups for chondrocyte nucleus loss, fibrosis, and giant cells (p\u2009=\u20090.005, 0.018, &lt;0.001, respectively). No difference was observed in cartilage thickness between AR and BR (p\u2009=\u20090.918). Chondrocyte nucleus loss was present in AR and BR but absent in AL and BL. Giant cells were detected in all VYC-20L and VYC-25L samples. Chronic inflammation and fibrosis varied but were not statistically significant. No abscess or necrosis was observed. This study demonstrated the histopathological effects of VYC-20L and VYC-25L on nasal cartilage using a rabbit model. Further studies with larger samples and diverse fillers are recommended.<\/jats:p>","DOI":"10.1055\/a-2541-2508","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T19:18:31Z","timestamp":1739906311000},"page":"039-045","source":"Crossref","is-referenced-by-count":0,"title":["Nonsurgical Rhinoplasty: Histopathological Effects of Dermal Fillers on Nasal Cartilage in a Rabbit Model"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-8412","authenticated-orcid":false,"given":"\u0130brahim \u00d6mer","family":"G\u00fcrlek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-214X","authenticated-orcid":false,"given":"Filiz","family":"G\u00fcl\u00fcstan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9232-6429","authenticated-orcid":false,"given":"Burak Kaan","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-6984","authenticated-orcid":false,"given":"Ahmet Bahad\u0131r","family":"G\u00f6kta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mehmet Akif \u0130nan Training and Research Hospital, \u015eanl\u0131urfa, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-8882","authenticated-orcid":false,"given":"\u00d6znur","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"\u0130stanbul Experimental Research, Development and Education Center (\u0130DEA), Mehmet Akif Ersoy Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-7835","authenticated-orcid":false,"given":"\u0130brahim","family":"Say\u0131n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-8177","authenticated-orcid":false,"given":"Kamil Hakan","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & Head and Neck Surgery, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/s-0042-1742431","article-title":"Nonsurgical rhinoplasty: long-term follow-up of high G\u2032 HA nasal injections","volume":"38","author":"D Bertossi","year":"2022","journal-title":"Facial Plast Surg"},{"issue":"23","key":"ref2","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1007\/s00266-024-04161-4","article-title":"Nonsurgical rhinoplasty: an updated systematic review of 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Esthet"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1001\/archfaci.10.4.250","article-title":"Study of rabbit septal cartilage grafts placed on the nasal dorsum","volume":"10","author":"M M Ale de Souza","year":"2008","journal-title":"Arch Facial Plast Surg"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1097\/MLG.0b013e3180f62b36","article-title":"Viability of crushed and diced cartilage grafts wrapped in oxidized regenerated cellulose and esterified hyaluronic acid: an experimental study","volume":"117","author":"K C Kazikdas","year":"2007","journal-title":"Laryngoscope"},{"issue":"S 01","key":"ref14","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1097\/DSS.0000000000001582","article-title":"Biochemistry, physiology, and tissue interactions of contemporary biodegradable injectable dermal fillers","volume":"44","author":"J L Herrmann","year":"2018","journal-title":"Dermatol 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