{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:45:52Z","timestamp":1788594352237,"version":"build-2803163510"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>5-Fluorouracil (5-FU) is an antimetabolite that inhibits fibroblast proliferation and collagen synthesis, making it valuable in facial plastic surgery for scar modulation and other conditions. This systematic review examines the indications, outcomes, and safety of 5-FU in facial plastic surgery. Due to methodological heterogeneity across studies, a narrative synthesis was performed. A comprehensive search of MEDLINE, Cochrane, SCOPUS, EMBASE, PubMed, and Web of Science identified 32 eligible studies (1,456 patients) from 4,772 screened articles. Indications included keloids, hypertrophic scars, contractures, periocular scars, granulomas from filler complications, nasal skin thickening, infections following thread lifts, resistant facial warts, and hypochromic lesions. Most studies reported reductions in scar size, erythema, and recurrence rates, with combination therapies enhancing outcomes. Adverse effects were mild and transient. However, variability in dosing, administration frequency, and follow-up underscores the need for standardized treatment guidelines and long-term studies.<\/jats:p>","DOI":"10.1055\/a-2541-2644","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T19:18:31Z","timestamp":1739906311000},"page":"028-038","source":"Crossref","is-referenced-by-count":2,"title":["5-Fluorouracil in Facial Plastic Surgery: Indications, Efficacy, and Safety \u2013 A Systematic Review and Narrative Synthesis"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-9861","authenticated-orcid":false,"given":"Ahmad","family":"Bogari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Facial Plastic Surgery Unit, King Saud University College of Medicine, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Jomah","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Facial Plastic Surgery Unit, King Saud University College of Medicine, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif","family":"Alshehri","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad F.","family":"Alrabiah","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Binghaith","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"AlOsaimi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Aldhwaihy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, Security Forces Hospital in Riyadh, Riyadh, Riyadh Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Baghazal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, AlSalamah Hospital, Jeddah, Makkah Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Bogari","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Makkah Province, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"issue":"08","key":"ref1","first-page":"1079","article-title":"Adverse granulomatous reaction to Artecoll treated by intralesional 5-fluorouracil and triamcinolone injections","volume":"32","author":"J S Conejo-Mir","year":"2006","journal-title":"Dermatol Surg"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.burns.2018.02.017","article-title":"The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: a randomized control trial","volume":"44","author":"F A Khalid","year":"2018","journal-title":"Burns"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0037-1617420","article-title":"Use of 5-fluorouracil for management of the thick-skinned 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