{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:04:26Z","timestamp":1790417066024,"version":"4.1.0"},"reference-count":105,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as acute lung injury, heart disease, and viral infections due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties. This compound plays a protective role in human pathophysiology. This review provides a comprehensive overview of the effects of andrographolide on cardiovascular disease and examines its essential roles and mechanisms in cardiovascular disease and other vascular dysfunctions. The data collected in this review serve as a comprehensive reference for the role of andrographolide in cardiovascular disease and provide valuable insights for further research and the development of andrographolide as a novel therapeutic approach for cardiovascular disease.<\/jats:p>","DOI":"10.1055\/a-2542-0756","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T23:49:16Z","timestamp":1741391356000},"page":"259-270","source":"Crossref","is-referenced-by-count":6,"title":["Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review"],"prefix":"10.1055","volume":"91","author":[{"given":"Shenjie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokai","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tongzhou People\u02bcs Hospital, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 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Zhang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-8741(97)01509-2","article-title":"Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat","volume":"56","author":"C Y Zhang","year":"1997","journal-title":"J Ethnopharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/tox.22906","article-title":"Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice","volume":"35","author":"K H Lin","year":"2020","journal-title":"Environ Toxicol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3389\/fphar.2017.00808","article-title":"Andrographolide Protects against aortic banding-induced experimental cardiac hypertrophy by inhibiting MAPKs signaling","volume":"8","author":"Q Q Wu","year":"2017","journal-title":"Front Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"GBD 2013 Mortality and Causes of Death Collaborators","year":"2015","journal-title":"Lancet"},{"key":"ref10","volume-title":"Meeting the Challenges in Developing Countries","author":"Institute of Medicine (US) Committee on Preventing the Global Epidemic of Cardiovascular Disease","year":"2010"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1161\/CIRCULATIONAHA.113.004042","article-title":"Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: The global burden of disease 2010 study","volume":"129","author":"A E Moran","year":"2014","journal-title":"Circulation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1093\/eurheartj\/sut003","article-title":"Perspectives: The burden of cardiovascular risk factors and coronary heart disease in Europe and worldwide","volume":"16","author":"G Vilahur","year":"2014","journal-title":"Eur Heart J Suppl"},{"key":"ref13","volume-title":"Global Atlas on Cardiovascular Disease Prevention and Control","author":"S Mendis","year":"2011"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejmech.2017.07.034","article-title":"Recent discoveries of anticancer flavonoids","volume":"142","author":"D Raffa","year":"2017","journal-title":"Eur J Med Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.gde.2004.04.012","article-title":"Pathophysiology and biochemistry of cardiovascular disease","volume":"14","author":"J Scott","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"ref16","first-page":"96","article-title":"Andrographolide, the active constituent of Andrographis paniculata Nees; a preliminary communication","volume":"86","author":"R N Chakravarti","year":"1951","journal-title":"Ind Med Gaz"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.intimp.2008.12.002","article-title":"In vitro and in vivo anti-inflammatory effects of andrographolide","volume":"9","author":"A A Abu-Ghefreh","year":"2009","journal-title":"Int Immunopharmacol"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00705-016-3166-3","article-title":"Broad-spectrum antiviral properties of andrographolide","volume":"162","author":"S Gupta","year":"2017","journal-title":"Arch Virol"},{"key":"ref19","first-page":"3032","article-title":"Andrographolide: Solving chemical instability and poor solubility by means of cocrystals","volume":"19","author":"K Suresh","year":"2013","journal-title":"Chemistry \u2013 A European journal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/13880209.2013.836544","article-title":"Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS\/MS method","volume":"52","author":"R Bera","year":"2014","journal-title":"Pharm Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1211\/jpp.61.11.0005","article-title":"Evaluation of molecular pharmaceutical and in-vivo properties of spray-dried isolated andrographolide\u2013PVP","volume":"61","author":"C Bothiraja","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"ref22","first-page":"82","article-title":"Absorption, distribution, and toxicity prediction of andrographolide and its derivatives as anti-HIV drugs","volume":"22","author":"S Megantara","year":"2018","journal-title":"Res J Chem 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participants","volume":"14","author":"P Songvut","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2016.03.017","article-title":"14-Deoxy-11, 12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells","volume":"300","author":"H K Tan","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"104885","DOI":"10.1016\/j.antiviral.2020.104885","article-title":"14-Deoxy-11, 12-didehydroandrographolide inhibits apoptosis in influenza A(H5N1) virus-infected human lung epithelial cells via the caspase-9-dependent intrinsic apoptotic pathway which contributes to its antiviral activity","volume":"181","author":"W Cai","year":"2020","journal-title":"Antiviral Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/nu12020523","article-title":"A diterpenoid, 14-deoxy-11, 12-didehydroandrographolide, in Andrographis paniculata reduces steatohepatitis and liver injury in mice fed a high-fat and high-cholesterol diet","volume":"12","author":"Y T Liu","year":"2020","journal-title":"Nutrients"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ptr.1275","article-title":"Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility","volume":"17","author":"R A Burgos","year":"2003","journal-title":"Phytother Res"},{"key":"ref33","first-page":"1103","article-title":"14-Deoxyandrographolide desensitizes hepatocytes to tumor necrosis factor-alpha-induced apoptosis through calcium-dependent tumor necrosis factor receptor superfamily member 1A release via the NO\/cGMP pathway","volume":"16","author":"D N Roy","year":"2010","journal-title":"Br J Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.fct.2013.05.056","article-title":"14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats","volume":"59","author":"S Mandal","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1440-1681.1998.tb02226.x","article-title":"Vasorelaxation of rat thoracic aorta caused by 14-deoxyandrographolide","volume":"25","author":"C Y Zhang","year":"1998","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.csbj.2020.11.033","article-title":"Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth","volume":"18","author":"J Zhang","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1002\/tox.23350","article-title":"Amelioratory effect of neoandrographolide on myocardial ischemic-reperfusion injury by its anti-inflammatory and anti-apoptotic activities","volume":"36","author":"Y Liu","year":"2021","journal-title":"Environ Toxicol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1080\/07391102.2022.2048078","article-title":"Dealkenylation of neoandrographolide, a phytochemical from Andrographis paniculata, stimulates FXR (Farnesoid X Receptor) and enhances gallstone dissolution","volume":"41","author":"R Sharma","year":"2023","journal-title":"J Biomol Struct Dyn"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jchromb.2015.03.014","article-title":"Simultaneous determination of andrographolide, dehydroandrographolide, and neoandrographolide in dog plasma by LC-MS\/MS and its application to a dog pharmacokinetic study of Andrographis paniculata tablet","volume":"990","author":"F F Xu","year":"2015","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"111132","DOI":"10.1016\/j.cbi.2024.111132","article-title":"Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway","volume":"399","author":"Y Duan","year":"2024","journal-title":"Chem Biol Interact"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcp.2017.01.011","article-title":"Dehydroandrographolide inhibits oral cancer cell migration and invasion through NF-\u03baB-, AP-1-, and SP-1-modulated matrix metalloproteinase-2 inhibition","volume":"130","author":"M J Hsieh","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"154753","DOI":"10.1016\/j.phymed.2023.154753","article-title":"The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis","volume":"114","author":"Z Pu","year":"2023","journal-title":"*Phytomedicine: international journal of phytotherapy and phytopharmacology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"08","DOI":"10.12703\/P7-08","article-title":"Pathophysiology of coronary artery disease leading to acute coronary syndromes","volume":"7","author":"J A Ambrose","year":"2015","journal-title":"F1000Prime Rep"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1210\/en.2010-0027","article-title":"PDGF beta-receptor kinase activity and ERK1\/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL","volume":"151","author":"R Getachew","year":"2010","journal-title":"Endocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/1874091X00802010135","article-title":"Biosynthesis of natural and hyperelongated chondroitin sulfate glycosaminoglycans: New insights into an elusive process","volume":"2","author":"P J Little","year":"2008","journal-title":"Open Biochem J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrcardio.2017.33","article-title":"Inflammatory processes in cardiovascular disease: A route to targeted therapies","volume":"14","author":"N Ruparelia","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"M A Alam","year":"2014","journal-title":"Adv Nutr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"116424","DOI":"10.1016\/j.taap.2023.116424","article-title":"Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis","volume":"462","author":"C W Lo","year":"2023","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.ATV.0000064374.15232.C3","article-title":"Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice","volume":"23","author":"H Kirii","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0021-9150(01)00587-1","article-title":"Involvement of ICAM-1 in the progression of atherosclerosis in APOE-knockout mice","volume":"160","author":"K Kitagawa","year":"2002","journal-title":"Atherosclerosis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1142\/S0192415X23500933","article-title":"Andrographolide attenuates oxidized LDL-induced activation of the NLRP3 inflammasome in bone marrow-derived macrophages and mitigates HFCCD-induced atherosclerosis in mice","volume":"51","author":"C C Chen","year":"2023","journal-title":"Am J Chin Med (Gard City N Y)"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"724718","DOI":"10.1155\/2014\/724718","article-title":"Evaluation of the effect of andrographolide on atherosclerotic rabbits induced by Porphyromonas gingivalis","volume":"2014","author":"R Al Batran","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00210-014-1041-x","article-title":"Insights into the anti-atherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits","volume":"387","author":"R Batran","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.nano.2018.06.010","article-title":"Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation","volume":"14","author":"T Wu","year":"2018","journal-title":"Nanomedicine"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.3390\/ijms22083850","article-title":"Endothelial dysfunction, inflammation and coronary artery disease: Potential biomarkers and promising therapeutical approaches","volume":"22","author":"D J Medina-Leyte","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.21037\/apm-20-960","article-title":"Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-\u03baB signaling pathways","volume":"9","author":"J Shu","year":"2020","journal-title":"Ann Palliat Med"},{"key":"ref57","first-page":"907","article-title":"Aortocoronary bypass saphenous vein graft atherosclerosis","volume":"40","author":"J T Lie","year":"1997","journal-title":"Am J Cardiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1378\/chest.88.3.341","article-title":"Morphologic changes in long-term saphenous vein bypass grafts","volume":"88","author":"J B Atkinson","year":"1985","journal-title":"Chest"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12013-010-9144-6","article-title":"Andrographolide inhibits intimal hyperplasia in a rat model of autogenous vein grafts","volume":"60","author":"Z T Zhu","year":"2011","journal-title":"Cell Biochem Biophys"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: Signaling pathways and novel therapeutic targets","volume":"89","author":"Y K Tham","year":"2015","journal-title":"Arch Toxicol"},{"key":"ref61","first-page":"968","article-title":"In vitro and in vivo performance of novel spray dried andrographolide loaded scleroglucan based formulation for dry powder inhaler","volume":"14","author":"A J Mali","year":"2017","journal-title":"Curr Drug Deliv"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1055\/s-2007-967181","article-title":"Cardiovascular effects of 14-deoxy-11, 12-didehydroandrographolide and Andrographis paniculata extracts","volume":"73","author":"N Yoopan","year":"2007","journal-title":"Planta Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/13880209.2022.2157021","article-title":"Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress","volume":"61","author":"Q Tian","year":"2023","journal-title":"Pharm Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2016.07.018","article-title":"Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice","volume":"192","author":"Y L Hsieh","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref65","first-page":"8786","article-title":"Acute myocardial infarction and myocardial ischemia-reperfusion injury: A comparison","volume":"8","author":"S Hashmi","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"174194","DOI":"10.1016\/j.ejphar.2021.174194","article-title":"Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca2+ and increase of cardiac transient outward K+ currents","volume":"906","author":"S E Elasoru","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pbiomolbio.2016.02.002","article-title":"Osteogenesis in calcified aortic valve disease: From histopathological observation towards molecular understanding","volume":"122","author":"X Liu","year":"2016","journal-title":"Prog Biophys Mol Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e006339","DOI":"10.1161\/JAHA.117.006339","article-title":"Valve interstitial cells: The key to understanding the pathophysiology of heart valve calcification","volume":"6","author":"A Rutkovskiy","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1161\/ATVBAHA.120.314789","article-title":"Cell-type transcriptome atlas of human aortic valves reveal cell heterogeneity and endothelial to mesenchymal transition involved in calcific aortic valve disease","volume":"40","author":"K Xu","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/HM9.0000000000000028","article-title":"Effects of adjuvant Chinese patent medicine therapy on major adverse cardiovascular events in patients with coronary heart disease angina pectoris: A population-based retrospective cohort study","volume":"2","author":"Y Liu","year":"2022","journal-title":"Acupunct Herb Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"7671638","DOI":"10.1155\/2019\/7671638","article-title":"Comparison of rapidly proliferating, multipotent aortic valve-derived stromal cells and valve interstitial cells in the human aortic valve","volume":"2019","author":"Y Huang","year":"2019","journal-title":"Stem Cells Int"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/ATVBAHA.122.318004","article-title":"High-density lipoprotein and long-term incidence and progression of aortic valve calcification: The Multi-Ethnic Study of Atherosclerosis","volume":"42","author":"A E Bortnick","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1039\/D1FO00813G","article-title":"Cardamonin inhibits osteogenic differentiation of human valve interstitial cells and ameliorates aortic valve calcification via interfering in the NF-\u03baB\/NLRP3 inflammasome pathway","volume":"12","author":"C Wang","year":"2021","journal-title":"Food Funct"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"871748","DOI":"10.3389\/fphar.2022.871748","article-title":"The natural product andrographolide ameliorates calcific aortic valve disease by regulating the proliferation of valve interstitial cells via the MAPK-ERK pathway","volume":"13","author":"Y Huang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"109985","DOI":"10.1016\/j.biopha.2020.109985","article-title":"The natural compound andrographolide inhibits human aortic valve interstitial cell calcification via the NF-kappa B\/Akt\/ERK pathway","volume":"125","author":"Y Huang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"102495","DOI":"10.1016\/j.ceca.2021.102495","article-title":"Andrographolide ameliorates aortic valve calcification by regulation of lipid biosynthesis and glycerolipid metabolism targeting MGLL expression in vitro and in vivo","volume":"100","author":"C Wang","year":"2021","journal-title":"Cell Calcium"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1070922","DOI":"10.3389\/fphar.2022.1070922","article-title":"Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways","volume":"13","author":"F Xie","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"D Zhang","year":"2019","journal-title":"Nature"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/bph.16332","article-title":"Andrographolide regulates H3 histone lactylation by interfering with p\u200a300 to alleviate aortic valve calcification","volume":"181","author":"C Wang","year":"2024","journal-title":"Br J Pharmacol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"D M Yellon","year":"2007","journal-title":"N Engl J Med"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.cardiores.2004.09.027","article-title":"Baicalein protects rat cardiomyocytes from hypoxia\/reoxygenation damage via prooxidant mechanism","volume":"65","author":"A Y Woo","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref82","first-page":"226","article-title":"Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia\/reoxygenation injury","volume":"325","author":"A YH Woo","year":"2008","journal-title":"Pharmacol Rev"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7150\/ijbs.37269","article-title":"Andrographolide protects against adverse cardiac remodeling after myocardial infarction through enhancing Nrf2 signaling pathway","volume":"16","author":"S Xie","year":"2020","journal-title":"Int J Biol Sci"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"13595","DOI":"10.1021\/acs.joc.9b01864","article-title":"Unusual ent-labdane diterpenoid dimers and their selective activation of TRPV channels","volume":"84","author":"S Gao","year":"2019","journal-title":"J Org Chem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3892\/ijmm.2021.5019","article-title":"Protective effects of andrographolide against cerebral ischemia reperfusion injury in mice","volume":"48","author":"Y Li","year":"2021","journal-title":"Int J Mol Med"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"9086747","DOI":"10.1155\/2018\/9086747","article-title":"Andrographolide ameliorates diabetic cardiomyopathy in mice by blockage of oxidative damage and NF-\u03baB-mediated inflammation","volume":"2018","author":"E Liang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2337\/db11-0477","article-title":"Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy","volume":"61","author":"M Rajesh","year":"2012","journal-title":"Diabetes"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diabetes.50.6.1414","article-title":"IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress","volume":"50","author":"J Kajstura","year":"2001","journal-title":"Diabetes"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"M Rajesh","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A global burden of disease 2010 study","volume":"129","author":"S S Chugh","year":"2014","journal-title":"Circulation"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.jacc.2020.02.025","article-title":"Atrial fibrillation: JACC council perspectives","volume":"75","author":"M K Chung","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0140-6736(10)60096-7","article-title":"New antiarrhythmic drugs for treatment of atrial fibrillation","volume":"375","author":"D Dobrev","year":"2010","journal-title":"Lancet"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"P204","DOI":"10.1186\/1532-429X-14-S1-P204","article-title":"Left atrial scar burden determined by delayed enhancement cardiac magnetic resonance at post radiofrequency ablation: association with atrial fibrillation recurrence","volume":"14","author":"G Brunner","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/europace\/euaa015","article-title":"Sex differences in catheter ablation of atrial fibrillation: Results from AXAFA-AFNET 5","volume":"22","author":"M Kloosterman","year":"2020","journal-title":"Europace"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","article-title":"Celastrol attenuates angiotensin II-induced cardiac remodeling by targeting STAT3","volume":"126","author":"S Ye","year":"2020","journal-title":"Circ Res"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/FJC.0000000000000281","article-title":"Autonomic remodeling: how atrial fibrillation begets atrial fibrillation in the first 24 hours","volume":"66","author":"L Zhang","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1631\/jzus.B2300086","article-title":"Andrographolide protects against atrial fibrillation by alleviating oxidative stress injury and promoting impaired mitochondrial bioenergetics","volume":"24","author":"P Yu","year":"2023","journal-title":"J Zhejiang Univ Sci 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critical role of cellular energetics","volume":"41","author":"M Tokarska-Schlattner","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11033-022-08042-4","article-title":"Andrographolide protects against doxorubicin-and arsenic trioxide-induced toxicity in cardiomyocytes","volume":"50","author":"L Safaeian","year":"2023","journal-title":"Mol Biol Rep"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3390\/ph16091196","article-title":"Efficacy of Kan Jang\u00ae in patients with mild COVID-19: A randomized, quadruple-blind, placebo-controlled trial","volume":"16","author":"L Ratiani","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"592","DOI":"10.4103\/1735-5362.389947","article-title":"Andrographis paniculata extract versus placebo in the treatment of COVID-19: A double-blinded randomized control 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