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Sleep disorders during the prodromal synucleinopathy period, primarily isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and daytime hypersomnolence correlate best with the recently proposed \u201cbody-first\u201d Lewy body disease progression. iRBD is the most widely recognized form of prodromal \u03b1-synucleinopathy, and patients with iRBD show abnormal \u03b1-synuclein in tissues and biofluids even in the absence of cognitive or motor symptoms. More importantly, individuals with iRBD have an elevated risk for near-term development of a clinically diagnosable symptomatic synucleinopathy. Other sleep disorders such as hypersomnia and circadian rhythm dysfunction also occur across the synucleinopathy spectrum, although their prognostic significance is less well understood than iRBD. Finally, isolated REM sleep without atonia may represent an even earlier stage of prodromal synucleinopathy, but further studies are needed.<\/jats:p>","DOI":"10.1055\/a-2544-1482","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:29:46Z","timestamp":1742257786000},"page":"348-357","source":"Crossref","is-referenced-by-count":3,"title":["Sleep and Prodromal Synucleinopathies"],"prefix":"10.1055","volume":"45","author":[{"given":"Johnson D.","family":"Pounders","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology, Division of Behavioral Neurology Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"McCarter","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology, Division of Behavioral Neurology Rochester, Minnesota"},{"name":"Mayo Clinic Center for Sleep Medicine, Division of Pulmonology, Rochester, 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of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group","volume":"45","author":"M Cesari","year":"2022","journal-title":"Sleep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"101745","DOI":"10.1016\/j.smrv.2023.101745","article-title":"Quantification of REM sleep without atonia: a review of study methods and meta-analysis of their performance for the diagnosis of RBD","volume":"68","author":"M Puligheddu","year":"2023","journal-title":"Sleep Med Rev"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5664\/jcsm.2670","article-title":"Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in a community-based sample","volume":"9","author":"B F Boeve","year":"2013","journal-title":"J Clin Sleep 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Kashiwagi","year":"2024","journal-title":"Cell"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"H Braak","year":"2003","journal-title":"Neurobiol Aging"},{"issue":"03","key":"ref41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/JPD-240002","article-title":"Parkinson's disease and dementia with Lewy bodies: one and the same","volume":"14","author":"P Borghammer","year":"2024","journal-title":"J Parkinsons Dis"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study","volume":"143","author":"J Horsager","year":"2020","journal-title":"Brain"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.clinph.2024.08.004","article-title":"Cortical activation in REM behavior disorder mimics voluntary movement. An electroencephalography study","volume":"166","author":"O Manzanilla","year":"2024","journal-title":"Clin Neurophysiol"},{"issue":"02","key":"ref44","doi-asserted-by":"crossref","first-page":"zsy227","DOI":"10.1093\/sleep\/zsy227","article-title":"Abnormal activation of motor cortical network during phasic REM sleep in idiopathic REM sleep behavior disorder","volume":"42","author":"J S Sunwoo","year":"2019","journal-title":"Sleep"},{"issue":"03","key":"ref45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/mds.30091","article-title":"Subthalamic \u03b3 Oscillation Underlying Rapid Eye Movement Sleep Abnormality in Parkinsonian Patients","volume":"40","author":"L Guan","year":"2025","journal-title":"Mov Disord"},{"issue":"06","key":"ref46","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/WNL.0b013e3181ec7fac","article-title":"REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century","volume":"75","author":"D O Claassen","year":"2010","journal-title":"Neurology"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41531-024-00813-z","article-title":"Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study","volume":"10","author":"B Orso","year":"2024","journal-title":"NPJ Parkinsons Dis"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1474-4422(23)00404-0","article-title":"A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria","volume":"23","author":"G U H\u00f6glinger","year":"2024","journal-title":"Lancet Neurol"},{"issue":"02","key":"ref49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1474-4422(23)00405-2","article-title":"A biological definition of neuronal \u03b1-synuclein disease: towards an integrated staging system for research","volume":"23","author":"T Simuni","year":"2024","journal-title":"Lancet Neurol"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00401-020-02160-8","article-title":"Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies","volume":"140","author":"M Rossi","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"03","key":"ref51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1474-4422(20)30449-X","article-title":"Detection of \u03b1-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study","volume":"20","author":"A Iranzo","year":"2021","journal-title":"Lancet Neurol"},{"issue":"18","key":"ref52","doi-asserted-by":"crossref","first-page":"e1944","DOI":"10.1212\/WNL.0000000000207147","article-title":"Misfolded \u03b1-synuclein assessment in the skin and CSF by RT-QuIC in isolated REM sleep behavior disorder","volume":"100","author":"A Iranzo","year":"2023","journal-title":"Neurology"},{"issue":"02","key":"ref53","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/brain\/awab431","article-title":"Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies","volume":"145","author":"I Poggiolini","year":"2022","journal-title":"Brain"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.3233\/JPD-230429","article-title":"Biofluid detection of pathological \u03b1-synuclein in the prodromal phase of synucleinopathies","volume":"14","author":"A Kluge","year":"2024","journal-title":"J Parkinsons Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"105567","DOI":"10.1016\/j.ebiom.2025.105567","article-title":"Evidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional study","volume":"112","author":"K Marek","year":"2025","journal-title":"EBioMedicine"},{"issue":"05","key":"ref56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1474-4422(23)00109-6","article-title":"Assessment of heterogeneity among participants in the Parkinson's progression markers Initiative cohort using \u03b1-synuclein seed amplification: a cross-sectional study","volume":"22","author":"A Siderowf","year":"2023","journal-title":"Lancet Neurol"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S1474-4422(24)00395-8","article-title":"Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study","volume":"23","author":"Y Ma","year":"2024","journal-title":"Lancet Neurol"},{"issue":"22","key":"ref58","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1212\/WNL.0000000000003989","article-title":"Skin nerve phosphorylated \u03b1-synuclein deposits in idiopathic REM sleep behavior 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stool","volume":"9","author":"A Schaffrath","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"issue":"20","key":"ref62","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1212\/WNL.0000000000002126","article-title":"Enteric nervous system \u03b1-synuclein immunoreactivity in idiopathic REM sleep behavior disorder","volume":"85","author":"F S Sprenger","year":"2015","journal-title":"Neurology"},{"issue":"23","key":"ref63","first-page":"e2364","article-title":"REM sleep behavior disorder and its possible prodromes in general population: prevalence, polysomnography findings, and associated factors","volume":"101","author":"W J Lee","year":"2023","journal-title":"Neurology"},{"issue":"10","key":"ref64","doi-asserted-by":"crossref","first-page":"zsz124","DOI":"10.1093\/sleep\/zsz124","article-title":"Normative and isolated rapid eye movement sleep without atonia in adults without REM sleep behavior disorder","volume":"42","author":"J C Feemster","year":"2019","journal-title":"Sleep"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.5664\/jcsm.5184","article-title":"Long-term follow-up investigation of isolated rapid eye movement sleep without atonia without rapid eye movement sleep behavior disorder: a pilot study","volume":"11","author":"A Stefani","year":"2015","journal-title":"J Clin Sleep Med"},{"issue":"06","key":"ref66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/ane.13156","article-title":"Rapid eye movement sleep without atonia constitutes increased risk for neurodegenerative disorders","volume":"140","author":"H O Dede","year":"2019","journal-title":"Acta Neurol Scand"},{"issue":"06","key":"ref67","first-page":"e627","article-title":"Evolution of prodromal REM sleep behavior disorder to neurodegeneration: a retrospective longitudinal case-control study","volume":"99","author":"Y Liu","year":"2022","journal-title":"Neurology"},{"issue":"06","key":"ref68","doi-asserted-by":"crossref","first-page":"551","DOI":"10.5664\/jcsm.27988","article-title":"Night-to-night variability of muscle tone, movements, and vocalizations in patients with REM sleep behavior disorder","volume":"6","author":"F Cygan","year":"2010","journal-title":"J Clin Sleep Med"},{"issue":"01","key":"ref69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.smrv.2010.02.004","article-title":"Sleep disorders and the natural history of Parkinson's disease: the contribution of epidemiological studies","volume":"15","author":"S Zoccolella","year":"2011","journal-title":"Sleep Med Rev"},{"issue":"06","key":"ref70","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/gps.1709","article-title":"Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease","volume":"22","author":"F Boddy","year":"2007","journal-title":"Int J Geriatr Psychiatry"},{"issue":"11","key":"ref71","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1002\/alz.13350","article-title":"Sleep disorders in Lewy body dementia: mechanisms, clinical relevance, and unanswered questions","volume":"19","author":"L TJ Townsend","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"05","key":"ref72","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ncpneuro0775","article-title":"Sleep disturbances in patients with parkinsonism","volume":"4","author":"V C De Cock","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"issue":"05","key":"ref73","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/mds.26865","article-title":"Alterations of the circadian system in Parkinson's disease patients","volume":"32","author":"K Fifel","year":"2017","journal-title":"Mov Disord"},{"issue":"05","key":"ref74","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/ije\/dyy098","article-title":"Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men","volume":"47","author":"Y Leng","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"09","key":"ref75","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1212\/01.wnl.0000183056.89590.0d","article-title":"Excessive daytime sleepiness and subsequent development of Parkinson disease","volume":"65","author":"R D Abbott","year":"2005","journal-title":"Neurology"},{"issue":"10","key":"ref76","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.5665\/sleep.5040","article-title":"Sleepiness in idiopathic REM sleep behavior disorder and Parkinson disease","volume":"38","author":"I 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