{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:01:35Z","timestamp":1790193695573,"version":"4.1.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endoscopic vacuum therapy (EVT) is a well-established method for managing gastrointestinal perforations. During the COVID pandemic, case reports demonstrated the effective use of EVT in controlling COVID-related diffuse duodenal bleeding. Owing to its unique mechanism of action, this approach may also be effective for other types of nonvariceal upper gastrointestinal bleeding (NVUGIB). This study aimed to assess EVT in the treatment of NVUGIB.<\/jats:p><jats:p>This retrospective analysis of a prospectively collected database included patients who underwent EVT for the treatment of NVUGIB. The primary outcome was clinical success. Secondary outcomes included technical success and safety. Subgroup analysis comparing the outcomes for patients with and without COVID was conducted.<\/jats:p><jats:p>19 patients underwent EVT for NVUGIB, with 57.9% having failed other therapies. Technical success occurred in all patients, and clinical success was achieved in 89.5%. There was no difference in the clinical success rates between patients with or without COVID (88% versus 91%, respectively). No procedure-related adverse events occurred. <\/jats:p><jats:p>EVT appears to be safe and effective in the management of NVUGIB. This approach could be particularly useful in refractory or diffuse bleeding. Larger studies are warranted to validate these findings.<\/jats:p>","DOI":"10.1055\/a-2544-6448","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:29:56Z","timestamp":1740166196000},"page":"883-889","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic vacuum therapy for the management of nonvariceal upper gastrointestinal bleeding: a valuable resource for the endoscopist\u2019s toolbox"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1272-8860","authenticated-orcid":false,"given":"Paulo Ferreira","family":"Mega","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit, Department of Gastroenterology, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3722","authenticated-orcid":false,"given":"Eduardo Guimar\u00e3es Hourneaux","family":"de Moura","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit, Department of Gastroenterology, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil"},{"name":"Gastrointestinal Endoscopy Division, Instituto D'Or de Pesquisa e Ensino, Hospital Vila Nova Star, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-2169","authenticated-orcid":false,"given":"Alexandre Moraes","family":"Bestetti","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit, Department of Gastroenterology, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil"},{"name":"Gastrointestinal Endoscopy Division, Instituto D'Or de Pesquisa e Ensino, Hospital Vila Nova Star, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Ramai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Kumar","sequence":"additional","affiliation":[{"name":"Piedmont Physicians Gastroenterology, Piedmont Healthcare Inc, Atlanta, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludhmila Abrah\u00e3o","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Division, Instituto D'Or de Pesquisa e Ensino, Hospital Vila Nova Star, Sao Paulo, Brazil"},{"name":"Department of Clinical Emergencies and Intensive Care, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-5270","authenticated-orcid":false,"given":"Christopher C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0355","authenticated-orcid":false,"given":"Diogo Turiani Hourneaux","family":"de Moura","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit, Department of Gastroenterology, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil"},{"name":"Gastrointestinal Endoscopy Division, Instituto D'Or de Pesquisa e Ensino, Hospital Vila Nova Star, Sao Paulo, 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