{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:43:37Z","timestamp":1789825417994,"version":"4.0.1"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["HE 1646\/5-1,HE 1646\/5-2"],"award-info":[{"award-number":["HE 1646\/5-1,HE 1646\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["HE 1646\/5-1,HE 1646\/5-2"],"award-info":[{"award-number":["HE 1646\/5-1,HE 1646\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die randomisierte kontrollierte, multizentrische TOSYMA-Studie zeigte eine \u00dcberlegenheit der Kombination aus digitaler Brust-Tomosynthese und synthetischer Mammografie (DBT+SM) gegen\u00fcber der digitalen Mammografie (DM) hinsichtlich der Detektionsrate invasiver Mammakarzinome im Stadium UICC I. In dieser Subanalyse wurden die mammografischen Tumorzeichen der in jedem Studienarm entdeckten Mammakarzinome im Stadium I, stratifiziert nach dem histologischen Grad, verglichen.<\/jats:p>\n                  <jats:p>Diese Subanalyse inkludierte im DBT+SM-Arm 49\u00a0462 Frauen und im DM-Arm 49 669 Frauen nach 1:1 Randomisierung von 7\/2018 bis 12\/2020. Die in der Konsensuskonferenz dokumentierten mammografischen Auff\u00e4lligkeiten wurden f\u00fcr Mammakarzinome im Stadium UICC I basierend auf verschiedenen Tumorzeichen (wie Herdbefunde, Mikroverkalkungen, Architekturst\u00f6rungen bzw. deren Kombination) erhoben. Berechnet wurden die Detektionsraten (pro 10\u00a0000 gescreenter Frauen) mit Differenzierung des Grads 1 von den Graden 2 oder 3.<\/jats:p>\n                  <jats:p>G1-Karzinome wurden mit DBT+SM bei 6,5\/10\u00a0000 gescreenter Frauen allein durch Herdbefunde (+1,5\/10\u00a0000 versus DM), bei 2,4\/10\u00a0000 (+1,6\/10\u00a0000) durch Architekturst\u00f6rungen und bei 1,2\/10\u00a0000 (+0,8\/10\u00a0000) durch Mikroverkalkungen detektiert. Mehrere Tumorzeichen (Kombinationen) lagen bei 7,9\/10\u00a0000 (+6,1\/10\u00a0000) vor. Grad-2- oder -3-Karzinome wurden mit DBT+SM bei 13,7\/10\u00a0000 allein durch Herdbefunde (+2,6\/10\u00a0000 versus DM), bei 4,9\/10\u00a0000 durch Mikroverkalkungen (+2,3\/10\u00a0000) und bei 3,6\/10\u00a0000 durch Architekturst\u00f6rungen (+2,0\/10\u00a0000) detektiert. Kombinationen von Tumorzeichen lagen bei 10,1\/10\u00a0000 (+6,3\/10\u00a0000) vor.<\/jats:p>\n                  <jats:p>Die Detektionsrate von Mammakarzinomen im UICC-Stadium I ist im DBT+SM-Screening h\u00f6her als im DM-Screening: Dazu tragen sowohl singul\u00e4re Tumorzeichen als auch ihre Kombinationen bei. Dabei werden im DBT+SM-Screening vor allem h\u00e4ufiger Mammakarzinome Grad 2 oder 3 im UICC-Stadium I entdeckt, was \u00fcberwiegend auf Kombinationen radiologischer Tumorzeichen zur\u00fcckzuf\u00fchren ist.<\/jats:p>","DOI":"10.1055\/a-2544-9085","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T19:36:39Z","timestamp":1743017799000},"page":"85-92","source":"Crossref","is-referenced-by-count":2,"title":["Radiologische Tumorzeichen von Mammakarzinomen im UICC-Stadium I: Subanalyse der randomisierten kontrollierten Studie TOSYMA"],"prefix":"10.1055","volume":"198","clinical-trial-number":[{"clinical-trial-number":"nct03377036","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-8831","authenticated-orcid":false,"given":"Stefanie","family":"Weigel","sequence":"additional","affiliation":[{"name":"Clinic for Radiology and Reference Center for Mammography M\u00fcnster, University of M\u00fcnster Faculty 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