{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:19:38Z","timestamp":1776223178344,"version":"3.50.1"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine the correlation between decreased or increased retinol-binding protein (RBP) levels during pregnancy and adverse pregnancy outcomes.<\/jats:p><jats:p>A retrospective cohort study was conducted to analyze the data of 16,094 pregnant women who participated in serum RBP level detection during pregnancy. The chi-square test or Mann\u2013Whitney U test was used for the univariate analysis of qualitative or quantitative data. Multiple logistic regression analysis, odds ratio (OR), and 95% confidence interval were used to evaluate the effect of RBP levels on adverse pregnancy outcomes.<\/jats:p><jats:p>The groups showed a significant difference in RBP levels (p\u2009&lt;\u20090.001). The results of multiple logistic regression analysis revealed that twins (OR\u2009=\u20092.631), upper respiratory tract infection (URTI, OR\u2009=\u20092.596), premature delivery (OR\u2009=\u20091.833), and macrosomia (OR\u2009=\u20091.524) were correlated with low retinol-binding protein (L-RBP), while preeclampsia (PE, OR\u2009=\u20090.147), intrahepatic cholestasis of pregnancy (OR\u2009=\u20091.654), gestational hypertension (GH, OR\u2009=\u20091.646), oligohydramnios (OR\u2009=\u20091.487), and advanced maternal age (OR\u2009=\u20091.470) were correlated with high retinol-binding protein (H-RBP). Decreased or increased RBP levels were correlated with hyperlipidemia (OR\u2009=\u20091.738, 2.857), Antenatal anemia (OR\u2009=\u20091.378, 0.791), gestational diabetes mellitus (GDM, OR\u2009=\u20091.272, 0.796), and small infant size (OR\u2009=\u20090.664, 1.444). L-RBP may indicate an increased risk of antenatal anemia and GDM, whereas H-RBP may indicate a decreased risk of antenatal anemia and GDM. Pregnant women with H-RBP were more likely to give birth to smaller infants, whereas those with L-RBP had a lower risk of this outcome. Additionally, mothers with H-RBP were not likely to give birth to male infants.<\/jats:p><jats:p>Hyperlipidemia, URTI, GH, PE, and GDM affect serum RBP levels, and these exposure factors can lead to different degrees of adverse pregnancy outcomes.<\/jats:p>","DOI":"10.1055\/a-2544-9158","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T19:37:06Z","timestamp":1740512226000},"page":"1846-1857","source":"Crossref","is-referenced-by-count":1,"title":["Association of Maternal Serum Retinol-Binding Protein Levels with Adverse Pregnancy Outcomes: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"42","author":[{"given":"Wenjing","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Medical Technology and Information Engineering, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelian","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Maternal and Child Health Hospital of Linping District, Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Maternal and Child Health Hospital of Linping District, Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Maternal and Child Health Hospital of Linping District, Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1532-6049","authenticated-orcid":false,"given":"Yiming","family":"Chen","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medical, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, People's Republic of China"},{"name":"Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/S0021-9258(18)46017-6","article-title":"Retinoids and retinoid-binding protein expression in rat adipocytes","volume":"267","author":"C Tsutsumi","year":"1992","journal-title":"J Biol 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