{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T23:40:06Z","timestamp":1746574806840,"version":"3.40.5"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to compare the nasal continuous positive airway pressure\n                        (nCPAP) and bi-level positive airway pressure (BiPAP) in preterm infants\n                        with respiratory distress syndrome (RDS).<\/jats:p><jats:p>Preterm infants (\u226432 weeks of gestation) were randomly assigned, at birth,\n                        into two study groups: nCPAP or BiPAP. Primary outcomes (surfactant\n                        administration and failure of non-invasive respiratory support within the\n                        first 72\u2009hours), and secondary outcomes (duration of ventilation support,\n                        pneumothorax, bronchopulmonary dysplasia, patent ductus arteriosus,\n                        necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of\n                        prematurity, time to total enteral feeding, length of hospital stay, and\n                        mortality) were assessed.<\/jats:p><jats:p>A total of 188 preterm infants with RDS were analysed. Mean gestational age\n                        was 28.8\u00b11.8 weeks (nCPAP) versus 29\u00b11.9 weeks (BiPAP). There were no\n                        statistically significant differences between groups in the failure of\n                        non-invasive respiratory support (25% vs. 33%, RR: 0.74, 95% CI: 0.47\u20131.17)\n                        or surfactant administration (35% vs. 38%, RR: 0.92, 95% CI: 0.49\u20131.71). No\n                        significant differences were observed in secondary outcomes between the two\n                        groups. Subgroup analysis of infants&lt;30 weeks yielded similar\n                        results.<\/jats:p><jats:p>Although two-level CPAP theoretically offers benefits, BiPAP was not superior\n                        to nCPAP as initial support in preterm infants with RDS. This underscores\n                        the continued value of the simpler, well-established nCPAP and the need for\n                        multicentre trials involving preterm infants of varying gestational\n                        ages.<\/jats:p>","DOI":"10.1055\/a-2546-1381","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T23:00:42Z","timestamp":1746572442000},"source":"Crossref","is-referenced-by-count":0,"title":["Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm\n                    Infants: A Randomized Controlled Trial"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-1834","authenticated-orcid":false,"given":"Sema","family":"Arayici","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Akdeniz University Faculty of Medicine,\n                    Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulsum Kadioglu","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences, Ankara City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgul","family":"Say","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Alanya Alaaddin Keykubat University, Alanya,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Yekta","family":"Oncel","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Izmir Katip Celebi University Faculty of\n                    Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Nur","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences, Ministry of\n                    Health Ankara City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurdan","family":"Uras","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Istinye University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evrim","family":"Dizdar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences, Ankara City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fped.2020.00270","article-title":"A Review on Noninvasive Respiratory Support for Management of Respiratory\n                    Distress in Extremely Preterm Infants","volume":"28","author":"Y Shi","year":"2020","journal-title":"Front 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(CPAP) in preterm infants \u226432 weeks: A retrospective cohort\n                    study","volume":"52","author":"Z H Rong","year":"2016","journal-title":"J Paediatr Child Health"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1111\/j.1651-2227.2010.01910.x","article-title":"Role of bilevel positive airway pressure in the management of preterm newborns\n                    who have received surfactant","volume":"99","author":"G Ancora","year":"2010","journal-title":"Acta Paediatr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"F85","DOI":"10.1136\/adc.2009.169219","article-title":"Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in\n                    preterm babies with respiratory distress syndrome: a randomised control\n                    trial","volume":"95","author":"G Lista","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12887-021-02741-w","article-title":"Non-invasive duo positive airway pressure ventilation versus nasal continuous\n                    positive airway pressure in preterm infants with respiratory distress syndrome:\n                    a randomized controlled trial","volume":"21","author":"A Malakian","year":"2021","journal-title":"BMC Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4172\/2167-0870.1000221","article-title":"Nasal bilevel vs continuous positive airway pressure in preterm infants: a\n                    randomized controlled trial","volume":"5","author":"T Aguiar","year":"2015","journal-title":"J Clin Trials"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ped.14061","article-title":"Effectiveness of nCPAP for moderate preterm infants compared to BiPAP: A\n                    Randomized, Controlled Non-Inferiority Trial","volume":"62","author":"M J Lee","year":"2020","journal-title":"Pediatr Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/2277-9175.174965","article-title":"Analysis and comparison of the effects of N-BiPAP and Bubble-CPAP in treatment\n                    of preterm newborns with the weight of below 1500 grams affiliated with\n                    respiratory distress syndrome: A randomised clinical trial","volume":"27","author":"A Sadeghnia","year":"2016","journal-title":"Adv Biomed Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304107.182","article-title":"Randomised controlled trial of synchronised intermittent positive airway\n                    pressure (SiPAP) versus continuous positive airway pressure (CPAP) as a primary\n                    mode of respiratory support in preterm infants with respiratory distress\n                    syndrome","volume":"98","author":"F E 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Pulmonol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.earlhumdev.2015.07.004","article-title":"N-BiPAP treatment in infants with respiratory distress syndrome: Apopulation\n                    study","volume":"91","author":"A L Solev\u00e5g","year":"2015","journal-title":"Early Hum Dev"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2546-1381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T23:00:43Z","timestamp":1746572443000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2546-1381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1055\/a-2546-1381","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]}}}