{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:45:11Z","timestamp":1792320311058,"version":"4.4.0"},"reference-count":53,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostate cancer (PCa) ranks among the most prevalent cancers in men, noted for\n                    its high mortality rate and unfavorable prognosis. Estrogen-related genes (ERGs)\n                    are significantly associated with the progression of PCa. This investigation\n                    aims to comprehensively assess the prognosis of PCa based on ERGs and explore\n                    its underlying biological mechanisms. Univariate, multivariate, and Least\n                    Absolute Shrinkage and Selection Operator (LASSO) regression analyses were\n                    conducted to identify prognostic signature genes and build a prognostic model.\n                    The model\u2019s predictive performance was assessed using Receiver Operating\n                    Characteristic (ROC) curve analysis. Gene Set Enrichment Analysis (GSEA), Gene\n                    Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment\n                    analyses were employed to investigate the underlying molecular mechanisms of\n                    PCa. Antitumor drugs with high sensitivity were predicted using the CellMiner\n                    database and the pRRophitic package. Additionally, miRNAs targeting the\n                    identified signature genes were predicted using the miRNet database. This study\n                    identified six ERGs as prognostic biomarkers for PCa: POU4F1, BMP2, PGF, GAS1,\n                    GNAZ, and FGF11. The findings indicated that individuals in the low-risk\n                    category exhibited improved prognostic results. Notably, PCa progression may be\n                    closely linked to the cell adhesion molecule pathway and epigenetic regulation.\n                    Additionally, hsa-let-7a-5p and hsa-miR-34a-5p were identified as potential\n                    therapeutic regulators for PCa treatment. In conclusion, this research offers\n                    novel perspectives into the progression of PCa, providing robust scientific\n                    support for the development of personalized treatment strategies for PCa\n                    patients.<\/jats:p>","DOI":"10.1055\/a-2548-1568","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T22:44:56Z","timestamp":1744325096000},"page":"273-285","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Assessment and Analysis of Underlying Biological\n                    Mechanisms of Prostate Cancer Based on Estrogen-Related Genes"],"prefix":"10.1055","volume":"57","author":[{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Urology Department, Affiliated Jinhua Hospital, Zhejiang University\n                    School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Die","family":"Fan","sequence":"additional","affiliation":[{"name":"Dental Department, Hubei Medical College Affiliated Shiyan People\u2019s\n                    Hospital, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Urology Department, Affiliated Jinhua Hospital, Zhejiang University\n                    School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Urology Department, Affiliated Jinhua Hospital, Zhejiang University\n                    School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Urology Department, Affiliated Jinhua Hospital, Zhejiang University\n                    School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Urology Department, Affiliated Jinhua Hospital, Zhejiang University\n                    School of Medicine, Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.3390\/molecules27175730","article-title":"Prostate cancer review: genetics, diagnosis, treatment options, and alternative\n                    approaches","volume":"27","author":"M Sekhoacha","year":"2022","journal-title":"Molecules"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.6004\/jnccn.2023.0050","article-title":"Prostate cancer, Version 4.2023, NCCN clinical practice guidelines in\n                    oncology","volume":"21","author":"E M Schaeffer","year":"2023","journal-title":"J Natl Compr Cancer Network"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s11427-022-2218-x","article-title":"Cancer statistics in Chinese older people, 2022: current burden, time trends,\n                    and comparisons with the US, Japan, and the Republic of Korea","volume":"66","author":"W Ju","year":"2023","journal-title":"Sci China Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3390\/biom10111536","article-title":"Curcumin against prostate cancer: current evidence","volume":"10","author":"D Termini","year":"2020","journal-title":"Biomolecules"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5694\/mja2.51722","article-title":"Modern paradigms for prostate cancer detection and management","volume":"217","author":"I S Williams","year":"2022","journal-title":"Med J Australia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-95693-0_1","article-title":"Brief overview of prostate cancer statistics, grading, diagnosis and treatment\n                    strategies","volume":"1095","author":"H Schatten","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s12951-023-02219-0","article-title":"Prostate cancer-derived small extracellular vesicle proteins: the hope in\n                    diagnosis, prognosis, and therapeutics","volume":"21","author":"H Chen","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-020-00243-0","article-title":"Prostate cancer","volume":"7","author":"R J Rebello","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/exd.14688","article-title":"Oestrogen inhibits psoriasis-like dermatitis induced by imiquimod in mice in\n                    relation to increased IL-10 producing cells despite elevated expression of\n                    IL-22, IL-23, IL-17 mRNA","volume":"32","author":"K Kobayashi","year":"2023","journal-title":"Exp Dermatol"},{"key":"ref10","first-page":"Cd010668","article-title":"Belimumab for systemic lupus erythematosus","volume":"2","author":"J A Singh","year":"2021","journal-title":"Cochrane Database System Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1161\/CIRCRESAHA.119.316100","article-title":"A critical role for estrogen-related receptor signaling in cardiac\n                    maturation","volume":"126","author":"T Sakamoto","year":"2020","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1109300","DOI":"10.3389\/fimmu.2023.1109300","article-title":"An estrogen response-related signature predicts response to immunotherapy in\n                    melanoma","volume":"14","author":"M Lin","year":"2023","journal-title":"Front Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e220182","DOI":"10.1530\/EC-22-0182","article-title":"Maintaining bone health by estrogen therapy in patients with advanced prostate\n                    cancer: a narrative review","volume":"11","author":"HJ T Coelingh Bennink","year":"2022","journal-title":"Endocr Connect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1038\/s41598-020-60844-3","article-title":"A systematic study of the impact of estrogens and selective estrogen receptor\n                    modulators on prostate cancer cell proliferation","volume":"10","author":"C Lafront","year":"2020","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"R179","DOI":"10.1530\/ERC-17-0493","article-title":"Sex steroids in the tumor microenvironment and prostate cancer progression","volume":"25","author":"C Boibessot","year":"2018","journal-title":"Endocr Relat Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e170809","DOI":"10.1172\/JCI170809","article-title":"The estrogen signaling pathway reprograms prostate cancer cell metabolism and\n                    supports proliferation and disease progression","volume":"134","author":"C Lafront","year":"2024","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41388-018-0438-2","article-title":"The role of PIP5K1\u03b1\/pAKT and targeted inhibition of growth of subtypes of breast\n                    cancer using PIP5K1\u03b1 inhibitor","volume":"38","author":"M Sarwar","year":"2019","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/bjh.18601","article-title":"Identification of a signature based on non-apoptotic regulatory cell death to\n                    improve prognosis prediction in acute myeloid leukaemia","volume":"201","author":"Y Zheng","year":"2023","journal-title":"Br J Haematol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"gkaf018","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded\n                    functionality and improved support for small counts and larger datasets","volume":"53","author":"Y Chen","year":"2025","journal-title":"Nucleic Acid Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2105-14-244","article-title":"R Circos: an R package for Circos 2D track plots","volume":"14","author":"H Zhang","year":"2013","journal-title":"BMC Bioinform"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"J Friedman","year":"2010","journal-title":"J Statist 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        cell populations using gene expression","volume":"17","author":"E Becht","year":"2016","journal-title":"Genome Biol"},{"key":"ref26","first-page":"3012","article-title":"GenVisR: genomic visualizations in R","volume":"32","author":"Z L Skidmore","year":"2016","journal-title":"Bioinformatics (Oxford, England)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e107468","DOI":"10.1371\/journal.pone.0107468","article-title":"pRRophetic: an R package for prediction of clinical chemotherapeutic response\n                    from tumor gene expression levels","volume":"9","author":"P Geeleher","year":"2014","journal-title":"PloS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/JU.0000000000003452","article-title":"Updates to advanced prostate cancer: AUA\/SUO guideline (2023)","volume":"209","author":"W Lowrance","year":"2023","journal-title":"J Urol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1158\/0008-5472.CAN-19-1231","article-title":"PGC1\u03b1 suppresses prostate cancer cell invasion through ERR\u03b1 transcriptional\n                    control","volume":"79","author":"L Valcarcel-Jimenez","year":"2019","journal-title":"Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.31557\/APJCP.2020.21.2.423","article-title":"Progesterone receptor expression in the benign prostatic hyperplasia and\n                    prostate cancer tissues, relation with transcription, growth factors, hormone\n                    reception and components of the AKT\/mTOR signaling athway","volume":"21","author":"L V Spirina","year":"2020","journal-title":"Asian Pacific J Cancer Prevent"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s10637-022-01298-4","article-title":"BMP2 as a promising anticancer approach: functions and molecular mechanisms","volume":"40","author":"T T Li","year":"2022","journal-title":"Invest New Drugs"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-019-09688-8","article-title":"Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon\n                    cancer","volume":"23","author":"D Unterleuthner","year":"2020","journal-title":"Angiogenesis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"102215","DOI":"10.1016\/j.plefa.2020.102215","article-title":"Long chain omega-3 fatty acids and their oxidized metabolites are associated\n                    with reduced prostate tumor growth","volume":"164","author":"J F Bilodeau","year":"2021","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/cac2.12469","article-title":"Bifidobacterium adolescentis orchestrates CD143(+) cancer-associated fibroblasts\n                    to suppress colorectal tumorigenesis by Wnt signaling-regulated GAS1","volume":"43","author":"S Chen","year":"2023","journal-title":"Cancer Commun (London, England)"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/15353702221131888","article-title":"GAS1RR, an immune-related enhancer RNA, is related to biochemical\n                    recurrence-free survival in prostate cancer","volume":"248","author":"Z Xiong","year":"2023","journal-title":"Exp Biol Med (Maywood, N.J.)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"145964","DOI":"10.1016\/j.gene.2021.145964","article-title":"Overexpressed GNAZ predicts poor outcome and promotes G0\/G1 cell cycle\n                    progression in hepatocellular carcinoma","volume":"807","author":"F Tian","year":"2022","journal-title":"Gene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molonc.2014.07.013","article-title":"Infiltrating T cells promote prostate cancer metastasis via modulation of\n                    FGF11\u2192miRNA-541\u2192androgen receptor (AR)\u2192MMP9 signaling","volume":"9","author":"S Hu","year":"2015","journal-title":"Mol Oncol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1874467212666190215112915","article-title":"Targeting chromatin remodeling for cancer therapy","volume":"12","author":"J Kaur","year":"2019","journal-title":"Curr Mol Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.3390\/ijms25053074","article-title":"The CHD protein kismet restricts the synaptic localization of cell adhesion\n                    molecules at the Drosophila neuromuscular junction","volume":"25","author":"I R Smith","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-013-9444-6","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer\n                    progression and metastasis","volume":"32","author":"N Beauchemin","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1040-8428(01)00171-8","article-title":"Cell adhesion molecules and adhesion abnormalities in prostate cancer","volume":"41","author":"M D Mason","year":"2002","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1212476","DOI":"10.3389\/fimmu.2023.1212476","article-title":"Cancer immunotherapies: advances and bottlenecks","volume":"14","author":"R Rui","year":"2023","journal-title":"Front Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.3390\/cells11182793","article-title":"Boosting the immune response-combining local and immune therapy for prostate\n                    cancer treatment","volume":"11","author":"J Karwacki","year":"2022","journal-title":"Cells"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41568-020-0267-9","article-title":"Prostate carcinogenesis: inflammatory storms","volume":"20","author":"J S de Bono","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/curroncol30040323","article-title":"Metastatic castration-resistant prostate cancer, immune checkpoint inhibitors,\n                    and beyond","volume":"30","author":"S M Lanka","year":"2023","journal-title":"Curr Oncology (Toronto, Ont.)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ccell.2020.08.007","article-title":"Nivolumab plus ipilimumab for metastatic castration-resistant prostate cancer:\n                    preliminary analysis of patients in the CheckMate 650 trial","volume":"38","author":"P Sharma","year":"2020","journal-title":"Cancer Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"107447","DOI":"10.1016\/j.pharmthera.2019.107447","article-title":"5-fluorouracil and other fluoropyrimidines in colorectal cancer: past, present\n                    and future","volume":"206","author":"S Vodenkova","year":"2020","journal-title":"Pharmacol Therap"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12943-023-01780-4","article-title":"Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through\n                    NSUN2\/YBX1\/QSOX1 axis in EGFR-mutant non-small-cell lung cancer","volume":"22","author":"Y Wang","year":"2023","journal-title":"Mol Cancer"},{"key":"ref49","first-page":"1638","article-title":"Let-7 microRNAs are possibly associated with perineural invasion in colorectal\n                    cancer by targeting IGF axis","volume":"12","author":"A M Niculae","year":"2022","journal-title":"Life (Basel, Switzerland)"},{"key":"ref50","first-page":"4493","article-title":"HSA-miR-34a-5p regulates the SIRT1\/TP53 axis in prostate cancer","volume":"14","author":"Y Wen","year":"2022","journal-title":"Am J Transl Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1169425","DOI":"10.3389\/fonc.2023.1169425","article-title":"An anoikis-related gene signature for prediction of the prognosis in prostate\n                    cancer","volume":"13","author":"X Zhao","year":"2023","journal-title":"Front Oncol"},{"key":"ref52","first-page":"43","article-title":"An endoplasmic reticulum stress-related signature featuring ASNS for predicting\n                    prognosis and immune landscape in prostate cancer","volume":"16","author":"Z Wu","year":"2024","journal-title":"Aging"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12894-023-01275-w","article-title":"Characterization of metabolism-associated molecular patterns in prostate\n                    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