{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T23:10:03Z","timestamp":1744326603776,"version":"3.40.4"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Charit\u00e9 Clinician Scientist Program","award":["to Tina Kienitz"],"award-info":[{"award-number":["to Tina Kienitz"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Shift work causes a disruption between the circadian system and the external\n                    light-dark cycle, but also a misalignment between various levels of the\n                    circadian system. There is no information on patients with adrenal insufficiency\n                    (AI) who are working shifts. The objective of the study was to analyze the\n                    hormone replacement therapy with hydrocortisone (HC) and the adaptation scheme\n                    in patients with AI on shifts. Patients working on shifts (n=15) from two German\n                    endocrine centers received a questionnaire regarding their therapy scheme, dose\n                    adaptations, working shifts, dose adaptations during working shifts, and\n                    occurrence of adrenal crisis. We observed that 20% of patients stated that they\n                    experience difficulties taking glucocorticoid replacement on time, 40% of\n                    patients reported these difficulties to occur only occasionally. Consequently,\n                    nearly half of the patients had forgotten to take their replacement therapy at\n                    some point. More than 50% of patients reported an adrenal crisis during the last\n                    two years. The timely adaptation of HC or of modified-release HC during shifts\n                    was very inhomogeneous. In conclusion, the adaptation schemes for HC dosing\n                    during shift work are currently not evidence-based but opinion-driven. Our\n                    findings highlight the need for further investigations of shift workers with\n                    AI.<\/jats:p>","DOI":"10.1055\/a-2549-5784","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T23:30:36Z","timestamp":1740958236000},"page":"236-241","source":"Crossref","is-referenced-by-count":0,"title":["Time Adjustment of Hydrocortisone Doses During Shift Work in Patients\n                    with Adrenal Insufficiency"],"prefix":"10.1055","volume":"57","author":[{"given":"Tina","family":"Kienitz","sequence":"additional","affiliation":[{"name":"Endocrinology, Endocrinology in Charlottenburg, Berlin,\n                    Germany"},{"name":"Department of Endocrinology and Metabolism, Charit\u00e9 \u2013\n                    Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu\n                    Berlin and Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Strasburger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Charit\u00e9 \u2013\n                    Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu\n                    Berlin and Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Elbelt","sequence":"additional","affiliation":[{"name":"Section Endocrinology\/Diabetology, Medical Clinic B,\n                    Universit\u00e4tsklinikum Ruppin-Brandenburg, Medizinische Hochschule Brandenburg,\n                    Neuruppin, Germany"},{"name":"Endocrinology, Endokrinologikum Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Lang","sequence":"additional","affiliation":[{"name":"Endocrinology, Endocrinology in Charlottenburg, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Charit\u00e9 \u2013\n                    Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu\n                    Berlin and Berlin Institute of Health, Berlin, Germany"},{"name":"Department of Human Nutrition, German Institute of Human Nutrition\n                    Potsdam-Rehbru\u0308cke, Nuthetal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bobbert","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Charit\u00e9 \u2013\n                    Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu\n                    Berlin and Berlin Institute of Health, Berlin, Germany"},{"name":"Department of Human Nutrition, German Institute of Human Nutrition\n                    Potsdam-Rehbru\u0308cke, Nuthetal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology, Endocrinology in Charlottenburg, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1530\/EJE-14-0824","article-title":"Adrenal crisis","volume":"172","author":"B Allolio","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.beem.2008.09.009","article-title":"Therapeutic management of adrenal insufficiency","volume":"23","author":"S Hahner","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-021-00252-7","article-title":"Adrenal insufficiency","volume":"7","author":"S Hahner","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S2213-8587(14)70142-1","article-title":"Diagnosis and management of adrenal insufficiency","volume":"3","author":"I Bancos","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1210\/jc.2015-1710","article-title":"Diagnosis and treatment of primary adrenal insufficiency: an endocrine society\n                    clinical practice guideline","volume":"101","author":"S R Bornstein","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","first-page":"882","article-title":"Nebennierenrinden-insuffizienz \u2013 Lebensbedrohliche erkrankung mit vielf\u00e4ltigen\n                    ursachen","volume":"110","author":"M Quinkler","year":"2013","journal-title":"Dtsch Arzteblatt Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/joim.12162","article-title":"Consensus statement on the diagnosis, treatment and follow-up of patients with\n                    primary adrenal insufficiency","volume":"275","author":"E S Husebye","year":"2014","journal-title":"J Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beem.2014.09.009","article-title":"Optimal glucocorticoid replacement in adrenal insufficiency","volume":"29","author":"M Oksnes","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.23736\/S0391-1977.17.02701-8","article-title":"Secondary adrenal insufficiency: from the physiopathology to the possible role\n                    of modified-release hydrocortisone treatment","volume":"43","author":"R M Paragliola","year":"2018","journal-title":"Minerva Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/cen.13267","article-title":"Management of glucocorticoid replacement in adrenal insufficiency shows notable\n                    heterogeneity \u2013 data from the EU-AIR","volume":"86","author":"R D Murray","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1530\/EJE-14-1114","article-title":"Modified-release hydrocortisone decreases BMI and HbA1c in patients with primary\n                    and secondary adrenal insufficiency","volume":"172","author":"M Quinkler","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/EJE-09-0170","article-title":"Improving glucocorticoid replacement therapy using a novel modified-release\n                    hydrocortisone tablet: a pharmacokinetic study","volume":"161","author":"G Johannsson","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1530\/EJE-17-0067","article-title":"Long-term safety of once-daily, dual-release hydrocortisone in patients with\n                    adrenal insufficiency: a phase 3b, open-label, extension study","volume":"176","author":"A G Nilsson","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/ejendo\/lvae107","article-title":"Conventional steroids vs. dual-release hydrocortisone on metabolic,\n                    cardiovascular, and bone outcomes in adrenal insufficiency: a 10-year study","volume":"191","author":"V Guarnotta","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"ref15","first-page":"75","article-title":"Dual-release hydrocortisone in Addison\u2019s disease \u2013 a review of the\n                    literature","volume":"10","author":"R Giordano","year":"2014","journal-title":"Eur Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/EJE-20-0642","article-title":"Cardiometabolic and psychological effects of dual-release hydrocortisone: a\n                    cross-over study","volume":"184","author":"R Dineen","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1210\/clinem\/dgad370","article-title":"Tissue glucocorticoid metabolism in adrenal insufficiency: a prospective study\n                    of dual-release hydrocortisone therapy","volume":"108","author":"R A Dineen","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/ejendo\/lvae037","article-title":"Monitoring adrenal insufficiency through salivary steroids: a pilot study","volume":"190","author":"L Tucci","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"ref19","first-page":"257","article-title":"Downloaded from [Internet]","author":"J D Veldhuis","year":"1989","journal-title":"Am J Physiol Endocrinol Metab at Charit\u00e9-Med.\n                    Bibliothek"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1530\/EJE-13-0450","article-title":"Perspectives on the management of adrenal insufficiency: clinical insights from\n                    across Europe","volume":"169","author":"A Grossman","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/EJE-08-0550","article-title":"Normal overall mortality rate in Addison\u2019s disease, but young patients are at\n                    risk of premature death","volume":"160","author":"M M Erichsen","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1210\/er.2009-0033","article-title":"Mortality in patients with pituitary disease","volume":"31","author":"M Sherlock","year":"2010","journal-title":"Endocr Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1210\/jc.2018-02298","article-title":"Sex-specific risk of cardiovascular disease in autoimmune Addison disease-a\n                    population-based cohort study","volume":"104","author":"J Skov","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/EJE-15-1096","article-title":"Reduction in daily hydrocortisone dose improves bone health in primary adrenal\n                    insufficiency","volume":"174","author":"J Schulz","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1530\/EJE-08-0880","article-title":"Glucocorticoid replacement therapy and pharmacogenetics in Addison\u2019s disease:\n                    effects on bone","volume":"160","author":"K L\u00f8v\u00e5s","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/jc.2014-3191","article-title":"High incidence of adrenal crisis in educated patients with chronic adrenal\n                    insufficiency: a prospective study","volume":"100","author":"S Hahner","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/07487304211064218","article-title":"Disturbance of the circadian system in shift work and its health impact","volume":"37","author":"D B Boivin","year":"2022","journal-title":"J Biol Rhythms"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.mehy.2011.06.002","article-title":"Hypotheses for mechanisms linking shiftwork and cancer","volume":"77","author":"L Fritschi","year":"2011","journal-title":"Med Hypotheses"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2478\/v10001-010-0032-5","article-title":"Shift work and metabolic syndrome, diabetes mellitus and ischaemic heart\n                    disease","volume":"23","author":"D Szosland","year":"2010","journal-title":"Int J Occup Med Environ Health"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.3390\/nu13114178","article-title":"The effects of shift work on cardio-metabolic diseases and eating patterns","volume":"13","author":"A Hemmer","year":"2021","journal-title":"Nutrients"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mce.2011.09.003","article-title":"Circadian system, sleep and endocrinology","volume":"349","author":"C J Morris","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse metabolic and cardiovascular consequences of circadian misalignment","volume":"106","author":"FAJ L Scheer","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/er.2015-1080","article-title":"The functional and clinical significance of the 24-hour rhythm of circulating\n                    glucocorticoids","volume":"38","author":"H Oster","year":"2017","journal-title":"Endocr Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/001401398186784","article-title":"Changes in cortisol secretion during shiftwork: implications for tolerance to\n                    shiftwork?","volume":"41","author":"J Hennig","year":"1998","journal-title":"Ergonomics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/BF00379398","article-title":"Effect of shift work on the night-time secretory patterns of melatonin,\n                    prolactin, cortisol and testosterone","volume":"60","author":"Y Touitou","year":"1990","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"ref36","first-page":"E608","article-title":"Internal dissociation of the circadian markers of the cortisol rhythm in night\n                    workers","volume":"270","author":"L Weibel","year":"1996","journal-title":"Am J Physiol"},{"key":"ref37","first-page":"R261","article-title":"The circadian melatonin and cortisol secretion pattern in permanent night shift\n                    workers","volume":"265","author":"M Roden","year":"1993","journal-title":"Am J Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/EJE-20-0181","article-title":"Standardised patient education in adrenal insufficiency: a prospective\n                    multi-centre evaluation","volume":"183","author":"S Burger-Stritt","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1037\/a0037885","article-title":"Sleepiness at work: a review and framework of how the physiology of sleepiness\n                    impacts the workplace","volume":"99","author":"H M Mullins","year":"2014","journal-title":"J Appl Psychol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/cen.12991","article-title":"Glucocorticoid therapy for adrenal insufficiency: nonadherence, concerns and\n                    dissatisfaction with information","volume":"84","author":"SC E Chapman","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.12968\/bjon.2024.33.3.120","article-title":"Considering the impact of shift working on health","volume":"33","author":"F Bostock","year":"2024","journal-title":"Br J Nurs"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1087-0792(98)90004-1","article-title":"Shift work and disturbed sleep\/wakefulness","volume":"2","author":"T Akerstedt","year":"1998","journal-title":"Sleep Med Rev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-3999(02)00438-5","article-title":"Prevalence and consequences of sleep disorders in a shift worker population","volume":"53","author":"M M Ohayon","year":"2002","journal-title":"J Psychosom Res"},{"key":"ref44","first-page":"3082","article-title":"Metabolic effects of short-term elevations of plasma cortisol are more\n                    pronounced in the evening than in the morning","volume":"84","author":"L Plat","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"bvad114.141","DOI":"10.1210\/jendso\/bvad114.141","article-title":"THU611 circadian misalignment of melatonin secretion in adrenal insufficiency\n                    (AI)","volume":"7","author":"M Darji","year":"2023","journal-title":"J Endocr Soc"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2549-5784.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T22:45:12Z","timestamp":1744325112000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2549-5784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,2]]},"references-count":45,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,4,10]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2549-5784","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published-other":{"date-parts":[[2025,3,2]]},"published":{"date-parts":[[2025,3,2]]}}}