{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:29:54Z","timestamp":1784060994393,"version":"3.55.0"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"ICMR-SRF","award":["45\/26\/2022-PHA\/BMS"],"award-info":[{"award-number":["45\/26\/2022-PHA\/BMS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclophosphamide (CP) is a potent anticancer drug, but nephrotoxicity is one of\n                    the vital organ toxicities that it causes as a side effect. We tried to evaluate\n                    the nephroprotective effect of levocabastine (LEV) in CP-induced nephrotoxicity\n                    in Swiss albino mice. Mice were given CP 200\u2009mg\/kg, i.p., once on the\n                        7th day. LEV (0.05 and 0.1\u2009mg\/kg, i.p.) and fenofibrate (FF)\n                    (80\u2009mg\/kg, p.o.) were given daily for 14 days. On the 15th day,\n                    animals were sacrificed and kidneys were removed for examination. The docking\n                    study showed significant binding of LEV and FF against TGF-\u03b21, which is a prime\n                    target molecule involved in nephrotoxicity. CP 200 group showed nephrotoxicity\n                    in terms of oxidative stress, apoptosis, inflammation, and fibrosis as\n                    manifested by decreased levels of SOD, catalase, GSH, blood urea\n                    nitrogen\/creatinine (BUN\/Cr) ratio, and increased TBARS, nitrite, TNF-\u03b1, IL-6,\n                    TGF-\u03b21, IL-1\u03b2, urea, uric acid, creatinine, and BUN. A decrease in body weight\n                    (BW) and an increase in kidney weight (KW) with an increased KW\/BW ratio was\n                    also observed. Cleaved caspase-3 and NF-\u03baB expression was also increased.\n                    Histopathological aberrations, like renal corpuscle damage, Bowman\u2019s space\n                    widening, glomerulus, mesangium cell disintegration, atrophic podocytes,\n                    vacuolation, and fibrotic changes were also seen. LEV 0.1 and FF 80\n                    significantly reversed these changes toward normal and showed nephroprotective\n                    potential. Thus, seeing the protective effect of LEV on CP-intoxicated mice, we\n                    conclude that LEV may be used as an adjuvant with CP in cancer, however, it\n                    needs more studies with the direct cancer model to confirm the claim.<\/jats:p>","DOI":"10.1055\/a-2552-2486","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T23:09:51Z","timestamp":1744672191000},"page":"148-161","source":"Crossref","is-referenced-by-count":1,"title":["Levocabastine ameliorates cyclophosphamide-induced nephrotoxicity in\n                    Swiss albino mice via NF-\u03baB\/cleaved caspase-3\/TGF-\u03b2 signaling\n                    pathways"],"prefix":"10.1055","volume":"75","author":[{"given":"Wasim","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Kalam","family":"Najmi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Mumtaz","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmaceutical\n                    Education and Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ehtaishamul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and\n                    Research, Jamia Hamdard, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/15353702221139206","article-title":"Phenethyl factor isothiocyanate protects against cyclophosphamide-induced\n                    nephrotoxicity via nuclear E2\u2013related factor 2 pathway in rats","volume":"248","author":"A B Uyumlu","year":"2023","journal-title":"Experimental Biology and Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2017.05.006","article-title":"Cyclophosphamide and acrolein induced oxidative stress leading to deterioration\n                    of metaphase II mouse oocyte quality","volume":"110","author":"R Jeelani","year":"2017","journal-title":"Free Radical Biology and 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