{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:44:31Z","timestamp":1785894271197,"version":"3.56.0"},"reference-count":170,"publisher":"Georg Thieme Verlag KG","issue":"06\/07","funder":[{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-66\/2024-03\/200032"],"award-info":[{"award-number":["451-03-66\/2024-03\/200032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Datura stramonium is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel\u02bcs trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its seeds), jimson weed (originating from the first recorded poisoning involving this plant), and apple of Peru (indicating the plant\u02bcs origin). All parts of the plant contain the tropane alkaloids hyoscyamine, scopolamine, and atropine together with several minor alkaloids, which cause poisoning such as typical anticholinergic syndrome with neuropsychiatric effects. A review of 114 papers from various databases (Scopus, Web of Science, PubMed, and Google Scholar) revealed that poisoning incidents involving this plant have been relatively common from 2001 to 2024. The analysis indicated that all cases of poisoning from D. stramonium can be categorized into two main groups: accidental and misuse. Accidental poisonings are primarily\n          linked to the contamination of other crops in the field, leading to mass poisoning of humans and animals. They can also result from misidentifying the plant as another edible species, children\u02bcs curiosity, and self-medication. On the other hand, misuse is typically associated with recreational drug use, suicide attempts, criminal activities, and magico-religious practices. To prevent poisoning from this plant, it is essential to eliminate the weed from fields, yards, gardens, and other disturbed areas. Additionally, it is important to educate the general public about the plant\u02bcs appearance and the dangers associated with its consumption, particularly in the context of self-medication and recreational drug use.<\/jats:p>","DOI":"10.1055\/a-2552-4434","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T01:14:08Z","timestamp":1742001248000},"page":"353-370","source":"Crossref","is-referenced-by-count":5,"title":["Datura stramonium \u2013 A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century"],"prefix":"10.1055","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-1412","authenticated-orcid":false,"given":"Milica","family":"A\u0107imovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Alternative and Vegetable Crops, Institute of Field and Vegetable Crops, Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref1","first-page":"10","article-title":"The genus Datura: From research subject to powerful hallucinogen","volume":"1","author":"K Bonde","year":"1998","journal-title":"EthnoLeaflets"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.forsciint.2004.03.011","article-title":"Fatal Datura poisoning: Identification of atropine and scopolamine by high performance liquid chromatography\/photodiode array\/mass spectrometry","volume":"145","author":"P A Steenkamp","year":"2004","journal-title":"Forensic Sci Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.2042-7158.1955.tb12051.x","article-title":"Structure of the roots of Datura stramonium L. and Datura tatula L","volume":"7","author":"B P Jackson","year":"1955","journal-title":"J Pharm 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using tobamoviruses","volume":"11","author":"D Mih\u00e1lik","year":"2022","journal-title":"Plants"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"107394","DOI":"10.1016\/j.ntt.2024.107394","article-title":"Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura stramonium","volume":"106","author":"O Bamisi","year":"2024","journal-title":"Neurotoxicol Teratol"},{"key":"ref17","first-page":"69","volume-title":"Drugs Affecting the Parasympathetic System","author":"P B Bradley","year":"1989"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/a-2283-2350","article-title":"Eye diseases: When the solution comes from plant alkaloids","volume":"90","author":"R Lorrai","year":"2024","journal-title":"Planta Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.jcrs.2006.04.039","article-title":"Preoperative use of atropine to prevent intraoperative 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