{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:51:22Z","timestamp":1774500682272,"version":"3.50.1"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"The Public Welfare Projects of Jinhua Science and Technology\n                        Bureau, Zhejiang Province","award":["2022-4-103"],"award-info":[{"award-number":["2022-4-103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast cancer (BC) threatens women\u2019s health, and the prognosis is dismal. Folic\n                    acid metabolism affects cancer prognosis, but research on folic acid\n                    metabolism-related genes (FMRs) in BC is scarce. We used TCGA-BRCA as the\n                    training set and GSE21653 as the validation set. Five FMRs (PLAT, SERPINA3,\n                    IFNG, SLC19A1, NFKB2) were screened via univariate and LASSO Cox regression\n                    analyses, and a prognostic model was built based on multivariate Cox regression\n                    analysis. The model showed excellent predictive performance. Differentially\n                    expressed genes in high- and low-risk groups were enriched in steroid hormone\n                    biosynthesis and neuroactive ligand-receptor interaction pathways. The low-risk\n                    group exhibited higher immune cell infiltration and better immunotherapy\n                    response. AM-5992 and 5-fluorodeoxyuridine 10mer may be potential BC drugs. This\n                    FMR-based model can accurately predict BC prognosis, offering a clinical\n                    reference.<\/jats:p>","DOI":"10.1055\/a-2554-4861","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T22:44:56Z","timestamp":1744325096000},"page":"262-272","source":"Crossref","is-referenced-by-count":1,"title":["A Breast Cancer Prognostic Model Based on Folic Acid\n                    Metabolism-Related Genes to Reveal the Immune Landscape"],"prefix":"10.1055","volume":"57","author":[{"given":"Lin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital,\n                    Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-3381","authenticated-orcid":false,"given":"Xiaotao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital,\n                    Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital,\n                    Zhejiang University School of Medicine, Jinhua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunlan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang\n                    University School of Medicine, Jinhua, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.3390\/ijms25094832","article-title":"Exploring the immunological profile in breast cancer: recent advances in\n 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