{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T22:44:56Z","timestamp":1777157096476,"version":"3.51.4"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This case report presents a 29-year-old male with diabetes mellitus who developed rhino-orbito-cerebral mucormycosis (ROCM) that was successfully treated with liposomal amphotericin B orbital injections. Despite emergent endoscopic debridement, the patient's disease progressed intracranially and intraorbitally, but he declined further surgical intervention. Subsequently, due to rapid acute vision loss, we initiated transcutaneous retrobulbar amphotericin B (TRAMB) injections. Following these injections, visual acuity, motility, and intraorbital fungal burden improved despite intracranial progression. This report highlights the benefits of TRAMB administration in aggressive fungal infections and explores the mechanisms behind its effectiveness, particularly in globe preservation. By targeting the infection in an area with a relatively robust blood supply, TRAMB reduces surgical difficulty and improves overall outcomes.<\/jats:p>","DOI":"10.1055\/a-2558-6468","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:36:21Z","timestamp":1742258181000},"page":"e72-e76","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative Administration of Amphotericin B in Orbital Mucormycosis Management: A Case Report"],"prefix":"10.1055","volume":"86","author":[{"given":"Russel T.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Berardinelli","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Napoli, Campania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie B.","family":"Fukui","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy","family":"Khalili","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil S.","family":"Mundi","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin B.","family":"Kassam","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Intent Medical Group, Endeavor Health Advanced Neurosciences Center, Northwest Community Hospital, Arlington Heights, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/13693780500464930","article-title":"The rising trend of invasive zygomycosis in patients with uncontrolled diabetes mellitus","volume":"44","author":"A Chakrabarti","year":"2006","journal-title":"Med Mycol"},{"issue":"05","key":"ref2","first-page":"425","article-title":"Retrobulbar injection of amphotericin B in patients with COVID-19 associated orbital mucormycosis: A systematic review","volume":"38","author":"A Sharifi","year":"2022","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"05","key":"ref3","first-page":"OD09","article-title":"Mucormycosis in a diabetic ketoacidosis patient: A case report","volume":"10","author":"S Biradar","year":"2016","journal-title":"J Clin Diagn Res"},{"issue":"S 06","key":"ref5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/1469-0691.12566","article-title":"Mucormycosis\u2013from the pathogens to the disease","volume":"20","author":"U Binder","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00405-022-07620-3","article-title":"Is mucormycosis the end? 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