{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T23:35:33Z","timestamp":1779406533414,"version":"3.53.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wrist Surg"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is not well known whether constant fingertip numbness (CN) or thenar muscle atrophy in advanced carpal tunnel syndrome (CTS) improves following carpal tunnel release (CTR).<\/jats:p>\n                  <jats:p>A total of 41 hands from 36 patients were enrolled in this prospective study. Patients endorsed CN (n\u2009=\u200938) and\/or presented on physical exam with thenar atrophy (TA; n\u2009=\u200918); 12 patients had both. After undergoing open CTR, patients were evaluated at 8 days, 3, 6, and 12 months following surgery. Outcomes assessed included Semmes\u2013Weinstein sensibility, grip strength, key-pinch strength, QuickDash scores, and atrophy via direct quantitative measurement.<\/jats:p>\n                  <jats:p>Six months postoperative, 83% of CN patients showed improved sensibility in any digit versus 40% of TA patients. Pinch strength was worse at baseline in TA patients (8.9\u2009\u00b1\u20093.7 vs. 10.8\u2009\u00b1\u20095.0) and returned to baseline in 72 and 80% of CN and TA patients at 6 months and 93.3 and 100% of CN and TA patients at 12 months. Hand function dissatisfaction improved to 100% satisfaction at 3 months. Tingling severity was characterized as \u201cnone\u201d from zero patients at baseline to 42, 72, and 62% of all patients at 3, 6, and 12 months. Atrophy patients presented with 1.4\u2009\u00b1\u20090.8\u2009mm of atrophy at baseline that improved by 1.2\u2009mm at 12 months.<\/jats:p>\n                  <jats:p>Patients with TA showed weaker pinch strengths at baseline but improved more rapidly than CN patients. Hand function significantly improved by 3 months and constant tip numbness resolved in roughly 2\/3 of all patients at 6 months.<\/jats:p>","DOI":"10.1055\/a-2558-7339","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T18:40:11Z","timestamp":1745865611000},"page":"251-256","source":"Crossref","is-referenced-by-count":1,"title":["Natural History of Constant Preoperative Fingertip Numbness and Thenar Atrophy Following Carpal Tunnel Release: A Prospective Study"],"prefix":"10.1055","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-978X","authenticated-orcid":false,"given":"Maheen","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Got","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel F.","family":"DaSilva","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Katarincic","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Akelman","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold-Peter C.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Brown University School of Medicine, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"I Atroshi","year":"1999","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2474-8-114","article-title":"Power grip, pinch grip, manual muscle testing or thenar atrophy - which should be assessed as a motor outcome after carpal tunnel decompression? A systematic review","volume":"8","author":"J Geere","year":"2007","journal-title":"BMC Musculoskelet Disord"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1445-2197.1997.tb01964.x","article-title":"Results of open carpal tunnel release: a comprehensive, retrospective study of 188 hands","volume":"67","author":"A Thurston","year":"1997","journal-title":"Aust N Z J Surg"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/(SICI)1097-0274(199903)35:3<232::AID-AJIM3>3.0.CO;2-G","article-title":"Clinical management of carpal tunnel syndrome: a 12-year review of outcomes","volume":"35","author":"M Feuerstein","year":"1999","journal-title":"Am J Ind Med"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2106\/00004623-198466010-00009","article-title":"Sensibility testing in patients with carpal tunnel syndrome","volume":"66","author":"R M Szabo","year":"1984","journal-title":"J Bone Joint Surg Am"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jhsa.2004.02.003","article-title":"Patient-reported outcome after carpal tunnel release for advanced disease: a prospective and longitudinal assessment in patients older than age 70","volume":"29","author":"M E Leit","year":"2004","journal-title":"J Hand Surg Am"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0363-5023(89)80091-7","article-title":"Analysis of pinch and grip strength after carpal tunnel release","volume":"14","author":"H Gellman","year":"1989","journal-title":"J Hand Surg Am"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2106\/00004623-198567020-00011","article-title":"Results of internal neurolysis of the median nerve for severe carpal-tunnel syndrome","volume":"67","author":"C E Rhoades","year":"1985","journal-title":"J Bone Joint Surg Am"},{"issue":"05","key":"ref9","first-page":"1038","article-title":"Development of the QuickDASH: comparison of three item-reduction approaches","volume":"87","author":"D E Beaton","year":"2005","journal-title":"J Bone Joint Surg Am"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1177\/1753193415622341","article-title":"Interpretation of the QuickDASH score after open carpal tunnel decompression: threshold values associated with patient satisfaction","volume":"41","author":"N D Clement","year":"2016","journal-title":"J Hand Surg Eur Vol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1302\/0301-620X.99B10.BJJ-2016-0587.R2","article-title":"Long-term outcome of carpal tunnel release surgery in patients with severe carpal tunnel syndrome","volume":"99-B","author":"C QY Tang","year":"2017","journal-title":"Bone Joint J"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/(SICI)1097-4598(199712)20:12<1477::AID-MUS1>3.0.CO;2-5","article-title":"AAEM minimonograph #26: the electrodiagnosis of carpal tunnel syndrome. American Association of Electrodiagnostic Medicine","volume":"20","author":"J C Stevens","year":"1997","journal-title":"Muscle Nerve"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.2106\/JBJS.G.01362","article-title":"The value added by electrodiagnostic testing in the diagnosis of carpal tunnel syndrome","volume":"90","author":"B Graham","year":"2008","journal-title":"J Bone Joint Surg Am"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jhsa.2018.11.010","article-title":"False-positive rates for nerve conduction studies and ultrasound in patients without clinical signs and symptoms of carpal tunnel syndrome","volume":"44","author":"J R Fowler","year":"2019","journal-title":"J Hand Surg Am"},{"issue":"04","key":"ref15","doi-asserted-by":"publisher","DOI":"10.5935\/0104-7795.20170037","article-title":"Correla\u00e7\u00e3o entre gravidade cl\u00ednica e estado funcional com achados eletroneuromiograficos, em pacientes com s\u00edndrome do t\u00fanel do carpo: uma revis\u00e3o sistem\u00e1tica","volume":"24","author":"A SF Nunes","year":"2017","journal-title":"Acta Fisiatr"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11552-012-9471-8","article-title":"Carpal tunnel syndrome with thenar atrophy: evaluation of the pinch and grip strength in patients undergoing surgical treatment","volume":"8","author":"C H Fernandes","year":"2013","journal-title":"Hand (N Y)"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/1753193419866646","article-title":"Carpal tunnel decompression in patients with normal nerve conduction studies","volume":"45","author":"S P Mackenzie","year":"2020","journal-title":"J Hand Surg Eur Vol"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2106\/00004623-198769060-00016","article-title":"Results of treatment of severe carpal-tunnel syndrome without internal neurolysis of the median nerve","volume":"69","author":"R H Gelberman","year":"1987","journal-title":"J Bone Joint Surg Am"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0363-5023(10)80099-1","article-title":"Internal neurolysis fails to improve the results of primary carpal tunnel decompression","volume":"16","author":"S E Mackinnon","year":"1991","journal-title":"J Hand Surg Am"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S1388-2457(01)00555-7","article-title":"Clinical and neurophysiological outcome of surgery in extreme carpal tunnel syndrome","volume":"112","author":"M Mondelli","year":"2001","journal-title":"Clin Neurophysiol"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0363-5023(97)80152-9","article-title":"Long-term symptom outcomes of carpal tunnel syndrome and its treatment","volume":"22","author":"F DeStefano","year":"1997","journal-title":"J Hand Surg Am"}],"container-title":["Journal of Wrist Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2558-7339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:55:32Z","timestamp":1779404132000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2558-7339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":21,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,5,21]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2558-7339","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2163-3916","2163-3924"],"issn-type":[{"value":"2163-3916","type":"print"},{"value":"2163-3924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]}}}