{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:48:00Z","timestamp":1785800880728,"version":"3.56.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n               Hintergrund Mit Einf\u00fchrung der optischen Koh\u00e4renztomografie (OCT) in die Glaukombildgebung kann das neuroretinale Gewebe von Netzhaut und Sehnervenkopf an unterschiedlichen Messpunkten deutlich genauer als mit vorigen Bildgebungstechniken vermessen und quantifiziert werden. Neben makul\u00e4ren Parametern wie der makul\u00e4ren und peripapill\u00e4ren Dicke der retinalen Nervenfasersicht und der makul\u00e4ren Ganglienzellschichtdicke wurden auch papillennahe Parameter basierend auf der Bruch-Membran-\u00d6ffnung (BMO) definiert und hinsichtlich ihrer Eignung zur Glaukomdiagnostik untersucht. Die vorliegende \u00dcbersicht stellt Vor- und Nachteile dieser Parameter in der Glaukomdiagnostik dar.<\/jats:p><jats:p>\n               Material und Methoden Zusammenfassung der Literatur aus PubMed sowie relevanter Leitlinien und Stellungnahmen.<\/jats:p><jats:p>\n               Ergebnisse und Schlussfolgerung Die minimale Randsaumweite der Bruch-Membran-\u00d6ffnung (BMO-MRW) ist der am h\u00e4ufigsten verwendete OCT-Parameter zur Vermessung des neuroretinalen Randsaums am Sehnervenkopf. Daneben existieren auch Fl\u00e4chenparameter. Im Vergleich zur peripapill\u00e4ren RNFL-Dicke sowie zu makul\u00e4ren Parametern weist die BMO-MRW eine gleichwertige bis \u00fcberlegene Sensitivit\u00e4t in der Glaukomerkennung auf. In der longitudinalen Betrachtung f\u00fchren Effekte wie \u00c4nderungen des Augendruckniveaus zu Fluktuationen in der BMO-MRW, was den Nutzen dieses Parameters bez. der morphometrischen Progressionsanalyse einschr\u00e4nkt. Hier konnte in zahlreichen Studien gezeigt werden, dass die peripapill\u00e4re Nervenfaserschichtdicke (pRNFL) besser zur Progressionsanalyse geeignet ist. Die \u00dcberpr\u00fcfung der automatischen Segmentierung der OCT-Aufnahmen ist f\u00fcr alle OCT-Parameter in der Glaukomdiagnostik relevant.<\/jats:p>","DOI":"10.1055\/a-2558-8721","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T22:30:17Z","timestamp":1753396217000},"page":"718-725","source":"Crossref","is-referenced-by-count":1,"title":["Glaucoma Diagnosis of the Optic Nerve Head Using Optical Coherence Tomography \u2013 Significance of Bruch\u02bcs Membrane Opening and Derived OCT Parameters"],"prefix":"10.1055","volume":"242","author":[{"given":"Philip","family":"Enders","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Augenheilkunde, Universit\u00e4t zu K\u00f6ln, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1055\/s-0033-1358168","article-title":"Spectral-Domain optische Koh\u00e4renztomografie der Makula: klinische Beurteilung","volume":"232","author":"U Kellner","year":"2015","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref2","first-page":"254","article-title":"Spectral domain optical coherence tomography in glaucoma: qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer (an AOS thesis)","volume":"107","author":"T C Chen","year":"2009","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1055\/s-0029-1245740","article-title":"OCT in der Makuladiagnostik \u2013 M\u00f6glichkeiten und Grenzen","volume":"228","author":"M A Gamulescu","year":"2011","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"041204","DOI":"10.1117\/1.2773736","article-title":"Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosis","volume":"12","author":"B Povazay","year":"2007","journal-title":"J Biomed Opt"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5778","DOI":"10.1167\/iovs.09-3790","article-title":"Automated segmentation of the cup and rim from spectral domain OCT of the optic nerve head","volume":"50","author":"M D Abr\u00e0moff","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/ICU.0000000000000231","article-title":"Optical coherence tomography platforms and parameters for glaucoma diagnosis and progression","volume":"27","author":"J C Mwanza","year":"2016","journal-title":"Curr Opin Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ajo.2013.04.016","article-title":"From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change","volume":"156","author":"B C Chauhan","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ophtha.2012.09.055","article-title":"Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter","volume":"120","author":"B C Chauhan","year":"2013","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1167\/iovs.05-1489","article-title":"Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry","volume":"47","author":"C Bowd","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1167\/iovs.11-9309","article-title":"Influence of clinically invisible, but optical coherence tomography detected, optic disc margin anatomy on neuroretinal rim evaluation","volume":"53","author":"A S Reis","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ajo.2013.11.007","article-title":"A method to estimate the amount of neuroretinal rim tissue in glaucoma: comparison with current methods for measuring rim area","volume":"157","author":"S K Gardiner","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1167\/iovs.14-15375","article-title":"Enhanced structure-function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement","volume":"56","author":"V M Danthurebandara","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.ophtha.2015.06.001","article-title":"Bruch\u02bcs Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study","volume":"122","author":"B C Chauhan","year":"2015","journal-title":"Ophthalmology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1136\/bjophthalmol-2016-308957","article-title":"The use of Bruch\u02bcs membrane opening-based optical coherence tomography of the optic nerve head for glaucoma detection in microdiscs","volume":"101","author":"P Enders","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/IJG.0000000000000532","article-title":"Bruch\u02bcs Membrane Opening-Minimum Rim Width Assessment With Spectral-Domain Optical Coherence Tomography Performs Better Than Confocal Scanning Laser Ophthalmoscopy in Discriminating Early Glaucoma Patients From Control Subjects","volume":"26","author":"A P Toshev","year":"2017","journal-title":"J Glaucoma"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/aos.13698","article-title":"Evaluation of two-dimensional Bruch\u02bcs membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort","volume":"97","author":"P Enders","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1038\/s41433-020-01296-x","article-title":"Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws","volume":"35","author":"A Sun","year":"2021","journal-title":"Eye (Lond)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ajo.2022.10.010","article-title":"Racial Differences in Detection of Glaucoma Using Retinal Nerve Fiber Layer Thickness and Bruch Membrane Opening Minimum Rim Width","volume":"246","author":"N W El-Nimri","year":"2023","journal-title":"Am J Ophthalmol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1055\/a-1478-3978","article-title":"Glaucoma Diagnostic Testing: The Influence of Optic Disc Size","volume":"239","author":"P Scheuble","year":"2022","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/eye.2017.306","article-title":"Medscape. Bruch\u02bcs membrane opening-based optical coherence tomography of the optic nerve head: a useful diagnostic tool to detect glaucoma in macrodiscs","volume":"32","author":"P Enders","year":"2018","journal-title":"Eye (Lond)"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6596","DOI":"10.1167\/iovs.16-20561","article-title":"Novel Bruch\u02bcs Membrane Opening Minimum Rim Area Equalizes Disc Size Dependency and Offers High Diagnostic Power for Glaucoma","volume":"57","author":"P Enders","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13874","DOI":"10.1038\/s41598-017-14284-1","article-title":"Optimization Strategies for Bruch\u02bcs Membrane Opening Minimum Rim Area Calculation: Sequential versus Simultaneous Minimization","volume":"7","author":"P Enders","year":"2017","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1097\/IJG.0000000000001947","article-title":"A Decrease in Bruch\u02bcs Membrane Opening-Minimum Rim Area Precedes Decreased Retinal Nerve Fiber Layer Thickness and Visual Field Loss in Glaucoma","volume":"30","author":"H S Choi","year":"2021","journal-title":"J Glaucoma"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s00417-016-3453-4","article-title":"Epiretinal membrane as a source of errors during the measurement of peripapillary nerve fibre thickness using spectral-domain optical coherence tomography (SD-OCT)","volume":"254","author":"F R\u00fcfer","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ogla.2023.12.002","article-title":"OCT Segmentation Errors with Bruch\u02bcs Membrane Opening-Minimum Rim Width as Compared with Retinal Nerve Fiber Layer Thickness","volume":"7","author":"H Yang","year":"2024","journal-title":"Ophthalmol Glaucoma"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"6886","DOI":"10.1167\/iovs.15-16701","article-title":"Structural Measurements for Monitoring Change in Glaucoma: Comparing Retinal Nerve Fiber Layer Thickness With Minimum Rim Width and Area","volume":"56","author":"S K Gardiner","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/IJG.0000000000001222","article-title":"Optical Coherence Tomography Segmentation Errors of the Retinal Nerve Fiber Layer Persist Over Time","volume":"28","author":"N Nagarkatti-Gude","year":"2019","journal-title":"J Glaucoma"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.1167\/iovs.17-22812","article-title":"Intraday Repeatability of Bruch\u02bcs Membrane Opening-Based Neuroretinal Rim Measurements","volume":"58","author":"P Enders","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ajo.2018.07.016","article-title":"Structural Reversal of Disc Cupping After Trabeculectomy Alters Bruch Membrane Opening-Based Parameters to Assess Neuroretinal Rim","volume":"194","author":"C Gietzelt","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.2147\/OPTH.S298045","article-title":"Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes","volume":"15","author":"S F Koenig","year":"2021","journal-title":"Clin Ophthalmol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ogla.2019.09.003","article-title":"Effect of Trabeculectomy on OCT Measurements of the Optic Nerve Head Neuroretinal Rim Tissue","volume":"3","author":"F G Sanchez","year":"2020","journal-title":"Ophthalmol Glaucoma"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s00417-016-3321-2","article-title":"Reversible structural and functional changes after intraocular pressure reduction in patients with glaucoma","volume":"254","author":"M Waisbourd","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1007\/s00417-022-05644-3","article-title":"Short-term changes in Bruch\u02bcs membrane opening-based morphometrics during the first week after trabeculectomy","volume":"260","author":"C Gietzelt","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ajo.2019.04.034","article-title":"Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability","volume":"207","author":"K Nouri-Mahdavi","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.18240\/ijo.2017.10.09","article-title":"Structure-function relationship comparison between retinal nerve fibre layer and Bruch\u02bcs membrane opening-minimum rim width in glaucoma","volume":"10","author":"L Reznicek","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00417-019-04557-y","article-title":"Structure-function relationship between Bruch\u02bcs membrane opening-minimum rim width and perimetry in open-angle glaucoma subtypes","volume":"258","author":"R Li","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1016\/j.ophtha.2015.08.020","article-title":"Importance of Normal Aging in Estimating the Rate of Glaucomatous Neuroretinal Rim and Retinal Nerve Fiber Layer Loss","volume":"122","author":"J R Vianna","year":"2015","journal-title":"Ophthalmology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1055\/a-1098-3466","article-title":"OCT-Diagnostik beim Glaukom: Tipps & Tricks","volume":"237","author":"C Mardin","year":"2020","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13195-022-00998-6","article-title":"The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals","volume":"14","author":"A L\u00f3pez-de-Eguileta","year":"2022","journal-title":"Alzheimers Res Ther"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2558-8721.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T22:30:23Z","timestamp":1753396223000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2558-8721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":39,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,7,24]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2558-8721","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}