{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:45:11Z","timestamp":1784115911687,"version":"3.55.0"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acanthamoebic keratitis (AK) is a sight-threatening infectious keratitis caused by Acanthamoeba. Timely and appropriate conservative treatment of AK can lead to a cure of the keratitis with good visual acuity, without the need for keratoplasty in the further course of the disease. In treatment-resistant cases, keratoplasty after intensive anti-amoebic therapy (AAT), so-called \u201clow-load keratoplasty\u201d, appears to offer a better overall prognosis and earlier visual and psychological rehabilitation than actively delayed keratoplasty (optical\/therapeutic). Further studies directly comparing early and delayed keratoplasty are needed to even better determine the optimal timing of corneal transplantation in AK.<\/jats:p>","DOI":"10.1055\/a-2558-8878","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T22:30:31Z","timestamp":1750113031000},"page":"629-635","source":"Crossref","is-referenced-by-count":4,"title":["Acanthamoeba Keratitis: What is the Best Time for Keratoplasty in Patients with Resistance to Conservative Therapy?"],"prefix":"10.1055","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-0222","authenticated-orcid":false,"given":"Yaser","family":"Abu Dail","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-3624","authenticated-orcid":false,"given":"Elias","family":"Flockerzi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"Dr. Rolf M. Schwiete Zentrum f\u00fcr Limbusstammzellforschung und kongenitale Aniridie, Universit\u00e4tsklinikum des Saarlandes, Homburg\/Saar, Deutschland"},{"name":"Klinik f\u00fcr Augenheilkunde, Semmelweis Universit\u00e4t, Budapest, Ungarn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8204","authenticated-orcid":false,"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg\/Saar, 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