{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:06:44Z","timestamp":1790824004285,"version":"4.1.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico\n          (n\u2009=\u200931, 84%), followed by in vitro studies (n\u2009=\u20094, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.<\/jats:p>","DOI":"10.1055\/a-2560-1844","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:34:56Z","timestamp":1742258096000},"page":"271-273","source":"Crossref","is-referenced-by-count":2,"title":["Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps"],"prefix":"10.1055","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-5964","authenticated-orcid":false,"given":"Amin","family":"Sharifan","sequence":"additional","affiliation":[{"name":"Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e1012","DOI":"10.1016\/S2214-109X(23)00198-5","article-title":"Description of the first global outbreak of mpox: An analysis of global surveillance data","volume":"11","author":"H Laurenson-Schafer","year":"2023","journal-title":"Lancet Glob Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1056\/NEJMe2416384","article-title":"Evolving Epidemiology of Mpox in Africa in 2024","volume":"392","author":"T A Ghebreyesus","year":"2025","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S0140-6736(24)02669-2","article-title":"Suspected and confirmed mpox cases in DR Congo: A retrospective analysis of national epidemiological and laboratory surveillance data, 2010\u201323","volume":"405","author":"E Bangwen","year":"2025","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"E1577","DOI":"10.1016\/S2214-109X(24)00363-2","article-title":"Mpox outbreaks in Africa constitute a public health emergency of continental security","volume":"12","author":"N Ndembi","year":"2024","journal-title":"Lancet Glob Health"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1056\/NEJMoa2411368","article-title":"Evolving Epidemiology of Mpox in Africa in 2024","volume":"392","author":"N Ndembi","year":"2025","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41577-022-00775-4","article-title":"Monkeypox: Disease epidemiology, host immunity and clinical interventions","volume":"22","author":"F M Lum","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1001\/jama.2024.21091","article-title":"Mpox clinical presentation, diagnostic approaches, and treatment strategies: A review","volume":"332","author":"B K Titanji","year":"2024","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e03586-23","DOI":"10.1128\/spectrum.03586-23","article-title":"Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease","volume":"12","author":"R R Mudhasani","year":"2024","journal-title":"Microbiol Spectr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"D J Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s41231-019-0050-7","article-title":"Lost in translation: The valley of death across preclinical and clinical divide \u2013 identification of problems and overcoming obstacles","volume":"4","author":"A A Seyhan","year":"2019","journal-title":"Transl Med Commun"}],"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2560-1844.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:30:55Z","timestamp":1745533855000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2560-1844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":10,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,4,24]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2560-1844","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3,17]]},"published":{"date-parts":[[2025,3,17]]}}}