{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:35:23Z","timestamp":1777332923909,"version":"3.51.4"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastrointestinal worm infestation, mainly by H. contortus, represents one of the main health challenges in sheep farming, exacerbated by resistance to conventional anthelmintics. This study evaluated the efficacy of two homeopathic complex formulations in reducing parasite load in ewes (not lactating\/not pregnant) over a period of 45 days.<\/jats:p>\n                  <jats:p>Thirty Santa In\u00eas and Dorper crossbred sheep were used, distributed in three treatments: T1 (Apis mellifica 15cH\u2009+\u2009Arsenicum album 11cH\u2009+\u2009Cina 9cH\u2009+\u2009Kalium phosphoricum 15cH\u2009+\u2009Spigelia anthelmia 9cH\u2009+\u2009Pereskia aculeata 6cH), T2 (the constituents of T1 but replacing Pereskia aculeata by Ferrum metallicum 6cH) and T3 (control group, without homeopathic treatment). The animals were evaluated by counting the EPG (eggs per gram of feces), monitoring level of anemia by the grade of ocular mucosal coloration (FAMACHA\u00ae method) and measuring body weight on each of days 0, 15, 30 and 45.<\/jats:p>\n                  <jats:p>The results showed a significant (p\u2009&lt;\u20090.05) decline in EPG from the 30th day, being more pronounced in group T2, which showed 79% efficacy on the 45th day. There were no significant differences between the treatments related to FAMACHA\u00ae score or daily weight gain.<\/jats:p>\n                  <jats:p>The homeopathic complexes used in this study, particularly T2 which contains Ferrum metallicum 6cH, contributed to the control of gastrointestinal nematode infection in dry ewes.<\/jats:p>","DOI":"10.1055\/a-2560-8431","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T23:14:29Z","timestamp":1756422869000},"page":"071-077","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Homeopathic Complexes in Gastrointestinal Nematode Control in Sheep"],"prefix":"10.1055","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6595-0264","authenticated-orcid":false,"given":"Ubirat\u00e3 Mariano","family":"de Souza","sequence":"additional","affiliation":[{"name":"ESALQ\/USP, Agronomia, Piracicaba, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-6915","authenticated-orcid":false,"given":"Ricardo Lopes Dias","family":"da Costa","sequence":"additional","affiliation":[{"name":"Scientific Research, Centro de Pesquisa e Desenvolvimento Zootecnia Diversificada, Instituto de Zootecnia, Nova Odessa, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-7813","authenticated-orcid":false,"given":"Luciana Morita","family":"Katiki","sequence":"additional","affiliation":[{"name":"Scientific Research, Centro de Pesquisa e Desenvolvimento Gen\u00e9tica e Biotecnologia, Instituto de Zootecnia, Nova Odessa, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1700-0547","authenticated-orcid":false,"given":"Rodrigo","family":"Giglioti","sequence":"additional","affiliation":[{"name":"Scientific Research, Centro de Pesquisa e Desenvolvimento Gen\u00e9tica e Biotecnologia, Instituto de Zootecnia, Nova Odessa, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-4097","authenticated-orcid":false,"given":"Lenira El Faro","family":"Zadra","sequence":"additional","affiliation":[{"name":"Scientific Research, Centro de Pesquisa e Melhoramento gen\u00e9tico de bovinos de leite, Instituto de Zootecnia, Zona Industrial, Sert\u00e3ozinho, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-8607","authenticated-orcid":false,"given":"Leandro","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"P&D GS-Technology in Natural Products, Centro, Itatiba, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-3572","authenticated-orcid":false,"given":"Cec\u00edlia Jos\u00e9","family":"Ver\u00edssimo","sequence":"additional","affiliation":[{"name":"Scientific Research, Centro de Pesquisa e Desenvolvimento Gen\u00e9tica e Biotecnologia, Instituto de Zootecnia, Nova Odessa, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/agriculture15030341","article-title":"Evaluation of grape pomace supplementation in lamb diets to mitigate Haemonchus contortus infection","volume":"15","author":"M O Mena","year":"2025","journal-title":"Agriculture"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1531233","DOI":"10.3389\/fvets.2025.1531233","article-title":"Tannin alleviated reproductive dysfunction in pregnant ewes infected with Haemonchus contortus","volume":"12","author":"X Li","year":"2025","journal-title":"Front Vet 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The rationale of the \u2018Simile\u2019","volume":"4","author":"P Bellavite","year":"2007","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref9","volume-title":"Organon da arte de curar de Samuel Hahnemann para o s\u00e9culo XXI","author":"M Pustiglione","year":"2021"},{"key":"ref10","first-page":"48","article-title":"Integrative healthcare: arriving at a working definition","volume":"10","author":"H Boon","year":"2004","journal-title":"Altern Ther Health Med"},{"key":"ref11","first-page":"51","article-title":"Fundamentals of homeopathy and principles of use in cattle","volume":"47","author":"M N Issautier","year":"2016","journal-title":"Point V\u00e9t"},{"key":"ref12","first-page":"273","volume-title":"Homeopathic veterinary medicine as an alternative treatment in ruminants","author":"V GG Rubio","year":"2024"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.25259\/JCH_2_2024","article-title":"Integration of homeopathy in one 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gastrointestinal nematodes in peripartum sheep","volume":"108","author":"P A Pacheco","year":"2019","journal-title":"Homeopathy"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.vetpar.2007.10.003","article-title":"Anthelmintic efficacy of neem (Azadirachta indica A. Juss) and the homeopathic product Fator Vermes in Morada Nova sheep","volume":"151","author":"A CS Chagas","year":"2008","journal-title":"Vet Parasitol"},{"key":"ref43","first-page":"23","article-title":"Efficacy of homeopathic treatment against natural infection of sheep by gastrointestinal nematodes","volume":"15","author":"R A da Rocha","year":"2006","journal-title":"Rev Bras Parasitol Vet"}],"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2560-8431.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:39:34Z","timestamp":1777329574000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2560-8431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":42,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,27]]},"published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2560-8431","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]}}}