{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:30Z","timestamp":1752105630521,"version":"3.41.2"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infectious encephalitis in children can be caused by several pathogens, very rarely this can be caused by bornaviruses (BoDV-1). Due to the recent discovery of the disease in humans and the small number of cases, especially pediatric infections, knowledge about the disease pathology as well as therapeutic options is limited. Therefore, this review shall help raise awareness of this rare and mostly fatal disease, promote an early diagnosis, and present current knowledge about possible treatment options.<\/jats:p>","DOI":"10.1055\/a-2561-8303","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T19:01:36Z","timestamp":1744657296000},"page":"221-225","source":"Crossref","is-referenced-by-count":0,"title":["Bornavirus (BoDV-1) Encephalitis in Children: Update on Diagnosis and Treatment"],"prefix":"10.1055","volume":"56","author":[{"given":"Victoria","family":"Lieft\u00fcchter","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"},{"name":"Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannik","family":"Vollmuth","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-5671","authenticated-orcid":false,"given":"Moritz","family":"Tacke","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"},{"name":"Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Paolini","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Finck","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Liesche-Starnecker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Faculty, University of Augsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"von Both","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"P\u00f6rtner","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Tappe","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Grosse","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJMc1803115","article-title":"Fatal encephalitic Borna disease virus 1 in solid-organ transplant recipients","volume":"379","author":"K Schlottau","year":"2018","journal-title":"N Engl J Med"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1056\/NEJMc1800724","article-title":"Fatal encephalitis associated with Borna disease virus 1","volume":"379","author":"K Korn","year":"2018","journal-title":"N Engl J Med"},{"issue":"03","key":"ref3","first-page":"147","article-title":"Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography","volume":"44","author":"R D\u00fcrrwald","year":"1997","journal-title":"Zentralbl Veterin\u00e4rmed B"},{"volume-title":"Ueber die hitzige Kopfkrankheit der Pferde: auf Verlangen des M\u00fcnsinger-Vereins zur Bef\u00f6rderung der Pferdezucht auf der Alp, und zun\u00e4chst f\u00fcr diese Gegend","year":"1823","author":"C F Autenrieth","key":"ref4"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s42451-022-00440-z","article-title":"Borna disease virus 1\u201c(BoDV-1)-Enzephalitis eines 18-J\u00e4hrigen au\u00dferhalb des bisher bekannten Endemiegebietes","volume":"5","author":"T Meyer","year":"2022","journal-title":"DGNeurologie"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"e2174778","DOI":"10.1080\/22221751.2023.2174778","article-title":"Risk factors for Borna disease virus 1 encephalitis in Germany - a case-control 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cell-mediated encephalitis caused by Borna disease virus. 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