{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:45:01Z","timestamp":1780933501613,"version":"3.54.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KL2 Career Development Program","award":["5KL2TR001874-08"],"award-info":[{"award-number":["5KL2TR001874-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A didelphys uterus is a rare M\u00fcllerian duct anomaly (MDA) caused by the incomplete fusion of the M\u00fcllerian ducts, leading to the formation of two distinct uterine cavities. The occurrence of simultaneous twin pregnancies, with each fetus developing in a separate horn of a didelphys uterus, is estimated at approximately 1 in 1,000,000 cases. This case report describes a rare instance of a spontaneous dichorionic diamniotic twin pregnancy, with one fetus in each horn of a didelphys uterus.<\/jats:p><jats:p>This is the case of a 35-year-old woman with unilateral renal agenesis who presented with a spontaneous dichorionic diamniotic twin pregnancy, with one fetus in each uterine cavity. This patient's pregnancy complications included intrahepatic cholestasis of pregnancy and rising creatinine levels, leading to a planned cesarean delivery at 36 weeks. The delivery was complicated by intrapartum hemorrhage and the postpartum course was further complicated by sepsis and endometritis.<\/jats:p><jats:p>This case highlights the complexity of managing a dichorionic diamniotic twin pregnancy in a didelphys uterus with concomitant congenital unilateral renal agenesis. It contributes to the understanding of optimal management strategies for MDA presentations and highlights the necessity for ongoing research into complications and long-term outcomes associated with such anomalies.<\/jats:p>","DOI":"10.1055\/a-2562-1607","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T23:53:11Z","timestamp":1742428391000},"page":"e53-e57","source":"Crossref","is-referenced-by-count":2,"title":["Di-Cavitary Twin Pregnancy in Didelphys Uterus with Associated Renal Agenesis"],"prefix":"10.1055","volume":"15","author":[{"given":"Helen","family":"Woolcock Martinez","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-069X","authenticated-orcid":false,"given":"Whitney A.","family":"Booker","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/humupd\/7.2.161","article-title":"Clinical implications of uterine malformations and hysteroscopic treatment results","volume":"7","author":"G F Grimbizis","year":"2001","journal-title":"Hum Reprod Update"},{"key":"ref2","first-page":"7279548","article-title":"Successful vaginal delivery of naturally conceived dicavitary twin in didelphys uterus: a rare reported case","volume":"2017","author":"H N Al Yaqoubi","year":"2017","journal-title":"Case Rep Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.epsc.2016.08.008","article-title":"Uterine didelphys with concomitant renal anomalies in both mother and fetus","volume":"14","author":"M Boehnke","year":"2016","journal-title":"J Pediatr Surg Case Rep"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1148\/rg.2021210022","article-title":"M\u00fcllerian duct anomalies: role in fertility and pregnancy","volume":"41","author":"M D Sugi","year":"2021","journal-title":"Radiographics"},{"issue":"14","key":"ref5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJMoa1516783","article-title":"Antenatal betamethasone for women at risk for late preterm delivery","volume":"374","author":"C Gyamfi-Bannerman","year":"2016","journal-title":"N Engl J Med"},{"key":"ref6","first-page":"29","volume-title":"Embryology and Development of Congenital Anomalies of the Pelvis and Female Organs","author":"V Naidoo","year":"2023"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpurol.2011.11.003","article-title":"Renal and urological abnormalities occurring with Mullerian anomalies","volume":"9","author":"M A Hall-Craggs","year":"2013","journal-title":"J Pediatr Urol"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpag.2021.04.013","article-title":"A retrospective analysis of female M\u00fcllerian duct anomalies in association with congenital renal abnormalities","volume":"34","author":"E RM Mooren","year":"2021","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0301-2115(99)00259-6","article-title":"Clinical implications of the didelphic uterus: long-term follow-up of 49 cases","volume":"91","author":"P K Heinonen","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/gmit.gmit_103_22","article-title":"Obstructed hemivagina and ipsilateral renal anomaly syndrome: a systematic review about diagnosis and surgical management","volume":"12","author":"G Moufawad","year":"2023","journal-title":"Gynecol Minim Invasive Ther"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"653.e1","DOI":"10.1016\/j.jpurol.2021.06.023","article-title":"Multiple variants of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome - 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