{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:47:59Z","timestamp":1773042479183,"version":"3.50.1"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study examined if analytical procedures influence the relationship between\n                    lactate metabolism and fat oxidation during exercise in 54 young men (age: 27\u00b17\n                    y; body fat: 23\u00b110%; VO2max: 46.9\u00b110.2\n                        mL\u00b7kg\u22121\u00b7min\u22121). The first lactate threshold was\n                    assessed using the log\u2013log transformation of blood lactate and running speed\n                    (LT1log\u2013log), an increase of 1 mM above the baseline (LT1Bsln1.0), and a fixed\n                    blood lactate concentration of 2 mM (LT1OBLA2). The second lactate threshold was\n                    determined using the maximal distance approach (LT2Dmax) and a fixed lactate\n                    concentration of 4 mM (LT2OBLA4). The highest (FATmax) and lowest (FATmin) fat\n                    oxidation rates were determined using a third-degree polynomial regression (P3),\n                    visual inspection, and mathematical modeling (SIN). FATmax and FATmin showed the\n                    strongest correlation with LT1log\u2013log (r: 0.65, p&lt;0.01) and\n                    LT2OBLA4 (r: 0.81, p&lt;0.01), regardless of fitness. FATmaxP3 and\n                    LTOBLA2 showed the best agreement in untrained individuals. Conversely, FATmaxP3\n                    and LT1log\u2013log showed the best agreement in obese men and trained subjects.\n                    LT2OBLA4 showed the best agreement with FATmin. When investigating the\n                    association between fat oxidation and lactate metabolism during exercise,\n                    LT1log\u2013log and LT2OBLA4 should be computed, while mathematical modeling or\n                    visual analysis should be applied for FATmax, depending on the fitness\n                    level.<\/jats:p>","DOI":"10.1055\/a-2563-9203","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:53:04Z","timestamp":1742518384000},"page":"577-587","source":"Crossref","is-referenced-by-count":2,"title":["Association of blood lactate accumulation with fat metabolism during\n                    exercise: method matters"],"prefix":"10.1055","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-5043","authenticated-orcid":false,"given":"Isaac Armando","family":"Chavez-Guevara","sequence":"additional","affiliation":[{"name":"Faculty of Sports, Universidad Autonoma de Baja\n                    California \u2013 Campus Ensenada, Ensenada, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ferri-Marini","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences, University of\n                    Groningen, University Medical Center Groningen, Groningen, The\n                    Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratko","family":"Peric","sequence":"additional","affiliation":[{"name":"Department for Exercise Physiology, Orthopedic Clinic Orthosport, Banja\n                    Luka, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-9016","authenticated-orcid":false,"given":"Brendan","family":"Egan","sequence":"additional","affiliation":[{"name":"School of Health and Human Performance, Dublin City\n                    University, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariazel","family":"Rubio-Valles","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Cultura Fisica, Universidad\n                    Autonoma de Chihuahua, Chihuahua, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Duron-Borjas","sequence":"additional","affiliation":[{"name":"Faculty of Sports, Universidad Autonoma de Baja\n                    California \u2013 Campus Ensenada, Ensenada, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulfo","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Instituto de Ciencias Biom\u00e9dicas,\n                    Universidad Aut\u00f3noma de Ciudad Ju\u00e1rez, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1113\/JP280955","article-title":"Lactate in contemporary biology: a phoenix risen","volume":"600","author":"G A Brooks","year":"2022","journal-title":"J Physiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1074\/jbc.M806409200","article-title":"Lactate inhibits lipolysis in fat cells through activation of an orphan\n                    G-protein-coupled receptor, GPR81","volume":"284","author":"C Liu","year":"2009","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1017\/S0007114511004673","article-title":"Lactate and the GPR81 receptor in metabolic regulation: implications for adipose\n                    tissue function and fatty acid utilization by muscle during 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observed sex\n                    differences","volume":"106","author":"O J Chrzanowski-Smith","year":"2021","journal-title":"Exp Physiol"},{"key":"ref36","first-page":"19","article-title":"Turning down lipid oxidation during heavy exercise--what is the mechanism?","volume":"59 Suppl 7","author":"K Sahlin","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1139\/H09-027","article-title":"Control of lipid oxidation at the mitochondrial level","volume":"34","author":"K Sahlin","year":"2009","journal-title":"Appl Physiol Nutr Metab"},{"issue":"06","key":"ref38","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2165\/00007256-200939060-00003","article-title":"Lactate threshold concepts: how valid are they","volume":"39","author":"O Faude","year":"2009","journal-title":"Sports Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.52082\/jssm.2021.170","article-title":"Maximal fat 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Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2563-9203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:39:57Z","timestamp":1751927997000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2563-9203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":40,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2563-9203","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3,20]]},"published":{"date-parts":[[2025,3,20]]}}}