{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:10:01Z","timestamp":1756854601961,"version":"3.44.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bisher gibt es keinen geeigneten Parameter f\u00fcr die Vorhersage des Auftretens\n                        einer azot\u00e4mischen chronischen Nierenerkrankung (CNE) nach der Behandlung\n                        einer Hyperthyreose bei Katzen. Ziel dieser Studie war es, klinische und\n                        labordiagnostische Marker sowie die sonografisch gemessene Nierenrindendicke\n                        als Pr\u00e4diktoren einer azot\u00e4mischen CNE nach einer Radiojodtherapie (RJT) zu\n                        untersuchen.<\/jats:p><jats:p>Katzen, vorgestellt f\u00fcr eine RJT (April 2021\u2013April 2022), wurden prospektiv\n                        eingeschlossen. Katzen mit einer Azot\u00e4mie (Kreatinin\u2265140 \u00b5mol\/L) und\/oder\n                        einer pathologischen Nierenmorphologie wurden ausgeschlossen. Nach der RJT\n                        wurden die Katzen \u00fcber 6\u201312 Monate kontrolliert (Messung des Gesamtthyroxins\n                        [TT4], des Thyreoidea-stimulierenden Hormons und des Kreatinins). Katzen mit\n                        persistierender Hyperthyreose und Katzen mit einem Follow up&lt;6 Monaten\n                        wurden von der statistischen Auswertung ausgeschlossen, da keine eindeutige\n                        Aussage bez\u00fcglich ihrer Schilddr\u00fcsen- und Nierenfunktion getroffen werden\n                        konnte. Folgende vor der RJT erhobene Parameter wurden zwischen Katzen, die\n                        nach der RJT eine azot\u00e4mische CNE entwickelten, und solchen, die\n                        nicht-azot\u00e4misch blieben, verglichen: Alter, Gewicht, Dauer seit der\n                        Diagnosestellung der Hyperthyreose bis zu der RJT, Blutdruck, H\u00e4matokrit,\n                        Konzentration von Kreatinin, Harnstoff, Kalium, Phosphat, TT4 und\n                        Symmetrisches Dimethylarginin, urinspezifisches Gewicht,\n                        Protein\/Kreatinin-Quotient im Urin sowie sonografisch gemessene\n                        Nierenrindendicke.<\/jats:p><jats:p>Es wurden 51 Katzen eingeschlossen, 29\/51 gingen in die statistische\n                        Auswertung ein (11\/29 wurden nach der RJT euthyreot und 18\/29 wurden\n                        hypothyreot). Es gab keinen Unterschied in der Frequenz der Azot\u00e4mie\n                        zwischen eu- und hypothyreoten Katzen (5\/11 vs. 6\/18, p=0,7). Keiner der\n                        untersuchten klinischen, labordiagnostischen sowie morphologischen Marker\n                        erwies sich als pr\u00e4diktiv f\u00fcr die Entwicklung einer azot\u00e4mischen CNE nach\n                        einer RJT.<\/jats:p><jats:p>Keiner der untersuchten Parameter war pr\u00e4diktiv f\u00fcr die Entwicklung einer\n                        azot\u00e4mischen CNE bei hyperthyreoten Katzen nach einer RJT. Aufgrund der\n                        kleinen Studienpopulation erscheinen zuk\u00fcnftige gr\u00f6\u00dfere Studien, vor allem\n                        hinsichtlich morphologischer Parameter, sinnvoll.<\/jats:p>","DOI":"10.1055\/a-2563-9702","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T22:33:44Z","timestamp":1756852424000},"page":"209-219","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation verschiedener Pr\u00e4diktoren einer chronischen\n                    Nierenerkrankung bei hyperthyreoten Katzen nach einer Radiojodtherapie \u2013 eine\n                    Pilotstudie"],"prefix":"10.1055","volume":"53","author":[{"given":"Anna Paulina","family":"Menzel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schaub","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Chirurgie, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"G\u00fcssow","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ve","family":"Patzelt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natali","family":"Bauer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Klinische Pathophysiologie und klinische\n                    Laboratoriumsdiagnostik, Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Hazuchova","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.15654\/TPK-150590","article-title":"Pr\u00e4valenz und Risikofaktoren der felinen Hyperthyreose in einer Klinikpopulation\n                    in S\u00fcddeutschland","volume":"44","author":"I 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Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2563-9702.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T22:33:47Z","timestamp":1756852427000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2563-9702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,9,2]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2563-9702","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}