{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:47:36Z","timestamp":1768344456596,"version":"3.49.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess the relationship\n                        between maternal anti-thyroid peroxidase (anti-TPO)-negative subclinical\n                        hypothyroidism (SCH) in the first trimester with complications of pregnancy\n                        and neonatal outcomes.<\/jats:p><jats:p>The study was done at a maternity and children's research training\n                        hospital. First-trimester thyroid function tests (TFTs) (free thyroxine\n                        (FT4), thyroid stimulating hormone (TSH), anti-TPO) were checked for mothers\n                        who gave birth at the center, and their newborns were accepted for the\n                        study. Based on the results of the TFTs, two groups were formed, the normal\n                        thyroid function (euthyroid) and SCH groups. The neonatal and maternal\n                        outcomes were noted. <\/jats:p><jats:p>This study included 150 mothers, of whom 110 (73.3%) had normal thyroid\n                        function and 40 (26.7%) had anti-TPO-negative subclinical hypothyroidism\n                        (SCH). Based on thyroid function tests (TSH: 0.1\u20134.0 mIU\/L, FT4: 0.7\u20131.8\n                        ng\/dL), significant differences in pregnancy complications wereobserved,\n                        with higher rates of placental abruption, preeclampsia, and postpartum\n                        hemorrhage in the SCH group (p&lt;0.001). Neonatal outcomes in the SCH group\n                        showed significantly higher rates of small for gestational age (SGA)\n                        (52.5%), NICU admission (77.5%), low Apgar score (52.5%), and transient\n                        tachypnea of the newborn (TTN) (67.5%) (all p&lt;0.001). Logistic regression\n                        analysis identified SCH as a significant risk factor for TTN (OR=7.24; 95%\n                        CI: 3\u201317; p&lt;0.001), while no significant associations were found with\n                        gestational age (p=0.194) or maternal age (p=0.600). <\/jats:p><jats:p>Anti-TPO-negative SCH in pregnancy has undesirable effects, not only during\n                        pregnancy but also in siblings, and surprisingly, it may be a risk factor\n                        for TTN.<\/jats:p>","DOI":"10.1055\/a-2564-0905","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T19:05:28Z","timestamp":1743793528000},"page":"350-354","source":"Crossref","is-referenced-by-count":1,"title":["Anti-TPO-Negative Subclinical Hypothyroidism in the First Trimester\n                    and Its Influences on Obstetric and Neonatal Outcomes"],"prefix":"10.1055","volume":"229","author":[{"given":"Nurdan","family":"Dinlen Fettah","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Kunt","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryem","family":"Sa\u011f\u0131r","sequence":"additional","affiliation":[{"name":"Gynecology, SBU Ankara Dr Sami Ulus Maternity Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fnay","family":"Soysal","sequence":"additional","affiliation":[{"name":"Gynecology, SBU Ankara Dr Sami Ulus Maternity Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 guidelines of the American Thyroid Association for the diagnosis and\n                    management of thyroid disease during pregnancy and the postpartum","volume":"27","author":"E K Alexander","year":"2017","journal-title":"Thyroid"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S2213-8587(17)30107-1","article-title":"Thyroid function and pregnancy outcomes: a systematic review and\n                    meta-analysis","volume":"5","author":"T I Korevaar","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1210\/jc.2016-1235","article-title":"Hypothyroidism in pregnancy: 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Gynecol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-7210.2019.04.005","article-title":"Management of thyroid disorders during pregnancy","author":"Chinese Medical Association","year":"2019"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0453","article-title":"Clinical guidelines for hypothyroidism in pregnancy","author":"American Thyroid Association","year":"2017"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/HJH.0000000000002714","article-title":"Thyroid hormone levels and vascular function in pregnancy","volume":"39","author":"J Figueiredo","year":"2021","journal-title":"J Hypertens"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3598","DOI":"10.1210\/jc.2018-00585","article-title":"Thyroid hormones and respiratory control in the newborn","volume":"103","author":"T Andoh","year":"2018","journal-title":"J Endocrinol 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Janson","year":"2020","journal-title":"Thyroid Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s12020-021-02779-2","article-title":"The impact of levothyroxine in pregnancy outcomes: a systematic review","volume":"72","author":"D Brown","year":"2021","journal-title":"Endocrine"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/AOG.0000000000004636","article-title":"Thyroid disease in pregnancy: evidence and guidelines","volume":"139","author":"S Reed","year":"2022","journal-title":"Obstet Gynecol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2564-0905.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:34:11Z","timestamp":1760394851000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2564-0905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":27,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2025,10,13]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2564-0905","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}