{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:31:41Z","timestamp":1755221501453,"version":"3.43.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> This study aimed to evaluate the efficacy of middle cerebral artery peak\n                        systolic velocity measurement in predicting moderate-to-severe fetal anemia\n                        and assess perinatal outcomes in patients who underwent intrauterine\n                        transfusion for fetal anemia.<\/jats:p><jats:p>A retrospective cohort of 91 pregnant women at risk of fetal anemia,\n                        delivered between 2016 and 2024, was studied. The efficacy of middle\n                        cerebral artery peak systolic velocity in predicting moderate-severe fetal\n                        anemia was assessed. Additionally, the perinatal outcomes of fetuses\n                        undergoing intrauterine transfusion were analyzed. <\/jats:p><jats:p>The middle cerebral artery peak systolic velocity threshold of 1.5 multiples\n                        of the median demonstrated a sensitivity of 92.3% and a specificity of 85.7%\n                        in predicting moderate-to-severe fetal anemia before the 35th gestational\n                        week. After the 35th gestational week, sensitivity and specificity were\n                        73.3% and 79.1%, respectively. A total of 53 intrauterine transfusion\n                        procedures were conducted on 24 patients. The survival rate among fetuses\n                        appropriately treated with intrauterine transfusion (n=22) was 68.2%, and\n                        the complication rate per procedure was 11.3%. All intrauterine and neonatal\n                        deaths (n=9) occurred in hydropic fetuses. All neonates who had undergone\n                        intrauterine transfusion were admitted to the neonatal intensive care unit\n                        for advanced care.<\/jats:p><jats:p>Middle cerebral artery Doppler is a valuable method for the screening and\n                        monitoring of fetal anemia, particularly before the 35th gestational week.\n                        Intrauterine transfusion should be considered the preferred treatment for\n                        moderate-to-severe fetal anemia. Given the potential risks and complications\n                        associated with intrauterine transfusion, hydropic fetuses appear to be at\n                        an elevated risk.<\/jats:p>","DOI":"10.1055\/a-2564-9371","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:04:47Z","timestamp":1744311887000},"page":"257-262","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and Treatment of Fetal Anemia: Eight Years Experience of a\n                    Tertiary Center"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0869-4660","authenticated-orcid":false,"given":"\u00d6mer G\u00f6khan","family":"Eyisoy","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Ministry of Health Yozgat\n                    City Hospital, Yozgat, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Konya City Hospital, Konya,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mucize","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Zeynep Kamil Women and\n                    Children\u02bcs Diseases Training and Research Hospital, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murad","family":"Gezer","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Zeynep Kamil Women and\n                    Children\u02bcs Diseases Training and Research Hospital, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oya","family":"Demirci","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine, Zeynep Kamil Women and\n                    Children\u02bcs Diseases Training and Research Hospital, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000362812","article-title":"Intrauterine blood transfusion: current indications and associated risks","volume":"36","author":"I T Lindenburg","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1097\/aog.0b013e31826d7dc1","article-title":"Management and prevention of red cell alloimmunization in pregnancy: a\n                    systematic review","volume":"120","author":"K J Moise","year":"2012","journal-title":"Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1056\/NEJMe068071","article-title":"Diagnosing hemolytic 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systematic review and\n                    meta-analysis","volume":"116","author":"S Pretlove","year":"2009","journal-title":"BJOG"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.7863\/jum.2005.24.4.425","article-title":"Middle cerebral artery peak systolic velocity: technique and variability","volume":"24","author":"G Mari","year":"2005","journal-title":"J Ultrasound Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/uog.17319","article-title":"Complications of intrauterine intravascular blood transfusion: lessons learned\n                    after 1678 procedures","volume":"50","author":"C Zwiers","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"141.e1","DOI":"10.1016\/j.ajog.2011.09.024","article-title":"Long-term neurodevelopmental outcome after intrauterine transfusion for\n                    hemolytic disease of the fetus\/newborn: the LOTUS study","volume":"206","author":"I T Lindenburg","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/s0002-9378(87)80226-0","article-title":"Percutaneous umbilical transfusion in severe rhesus isoimmunization: resolution\n                    of fetal hydrops","volume":"157","author":"M L Socol","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.5152\/TurkPediatriArs.2018.01816","article-title":"Turkish Neonatal Society guideline to the approach, follow-up, and treatment of\n                    neonatal jaundice","volume":"53","author":"A \u00c7oban","year":"2018","journal-title":"Turk Pediatri Ars"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/j.1471-0528.2002.01314.x","article-title":"Longitudinal measurement of peak systolic velocity in the fetal middle cerebral\n                    artery for monitoring pregnancies complicated by red cell alloimmunisation: a\n                    prospective multicentre trial with intention-to-treat","volume":"109","author":"R Zimmermann","year":"2002","journal-title":"BJOG"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1067\/s0002-9378(03)00771-3","article-title":"Conventional management of maternal red cell alloimmunization compared with\n                    management by Doppler assessment of middle cerebral artery peak systolic\n                    velocity","volume":"189","author":"L Pereira","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000456661","article-title":"Accuracy of middle cerebral artery Doppler assessment between 34 and 37 weeks in\n                    fetuses with red cell alloimmunization","volume":"42","author":"E Maisonneuve","year":"2017","journal-title":"Fetal Diagn Ther"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1080\/01443615.2019.1647521","article-title":"Perinatal outcomes of intrauterine transfusion for foetal anaemia due to red\n                    blood cell alloimmunisation","volume":"40","author":"A\u00d6 \u015eavkli","year":"2020","journal-title":"J Obstet Gynaecol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1067\/mob.2001.116690","article-title":"The severity of immune fetal hydrops is predictive of fetal outcome after\n                    intrauterine treatment","volume":"185","author":"I L van Kamp","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1111\/jog.14746","article-title":"Nationwide survey of intrauterine blood transfusion for fetal anemia in\n                    Japan","volume":"47","author":"M Mizuuchi","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00404-015-3915-7","article-title":"Perinatal survival and procedure-related complications after intrauterine\n                    transfusion for red cell alloimmunization","volume":"293","author":"D Deka","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1159\/000328683","article-title":"Procedure-related complications and perinatal outcome after intrauterine\n                    transfusions in red cell alloimmunization in Stockholm","volume":"30","author":"E Tiblad","year":"2011","journal-title":"Fetal Diag Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13224-024-01985-7","article-title":"Intrauterine transfusion for fetal anemia: An 8-year experience from a tertiary\n                    care center","author":"Z Dias","year":"2024","journal-title":"Journal Obstet Gynecol India"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s13224-018-1108-6","article-title":"Perinatal outcome after intrauterine transfusion in Rh isoimmunized mothers","volume":"69","author":"O Potdar","year":"2019","journal-title":"J Obstet Gynecol India"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2564-9371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T22:40:49Z","timestamp":1754692849000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2564-9371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":21,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,8,8]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2564-9371","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2025,4,10]]}}}