{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:00:23Z","timestamp":1785333623211,"version":"3.55.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2016YFC0901405,2023YFC2507000"],"award-info":[{"award-number":["2016YFC0901405,2023YFC2507000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science & Technology Fundamental Resources Investigation Program of China","award":["2019FY101105"],"award-info":[{"award-number":["2019FY101105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study estimated the participation rate and effectiveness of endoscopic screening of upper gastrointestinal cancer (UGIC) in China.<\/jats:p><jats:p>From 2014 to 2015, we recruited 192805 adults from seven cities in China to build a prospective cohort for UGIC screening, including esophageal cancer and gastric cancer. Overall, 39991 participants were at high risk for UGIC according to an established risk score system and were recommended for endoscopic examination. Participation rates were reported, and their associated factors were explored. After inverse probability of treatment weighting (IPTW) based on propensity scores, Poisson regression was used to estimate the incidence rate ratio (IRR) and 95%CI for UGIC incidence and mortality between screened and non-screened groups from cohort entry until 31 December 2021.<\/jats:p><jats:p>10442 participants underwent endoscopy, giving a participation rate of 26.1%. Higher\n        participation was observed among individuals with higher education levels, history of upper\n        gastrointestinal diseases, and family history of cancer. After a median follow-up of 6.8\n        years (interquartile range 6.7\u20136.9), UGIC incidences after IPTW were 94.6 per 100000\n        person-years in the screened group and 84.7 per 100000 person-years in the non-screened\n        group. The weighted UGIC mortality rates were 13.1 and 33.4 per 100 000 person-years,\n        respectively. The screened group had significantly lower UGIC mortality than the\n        non-screened group, with a weighted IRR of 0.39 (95%CI 0.19\u20130.82).<\/jats:p><jats:p>Participation in endoscopic screening among a high-risk UGIC population in China was low. We found that one-time endoscopic screening significantly reduced mortality caused by UGIC.<\/jats:p>","DOI":"10.1055\/a-2564-9756","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:56:41Z","timestamp":1744142201000},"page":"972-979","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of the participation rate and effectiveness of upper gastrointestinal cancer screening in China: a multicenter population-based screening study"],"prefix":"10.1055","volume":"57","author":[{"given":"Song","family":"Song","sequence":"first","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyi","family":"Geng","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Chen","sequence":"additional","affiliation":[{"name":"National Central Cancer Registry, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongshou","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Central Cancer Registry, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-9056","authenticated-orcid":false,"given":"Wenqiang","family":"Wei","sequence":"additional","affiliation":[{"name":"National Central Cancer Registry, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Ren","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening, National Cancer Center \/ National Clinical Research Center for Cancer \/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3760\/cma.j.cn112152-20240119-00035","article-title":"Cancer incidence and mortality in China, 2022","volume":"04","author":"B Han","year":"2024","journal-title":"J Natl Cancer Cent"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1111\/cas.13606","article-title":"Endoscopy screening effect on stage distributions of esophageal cancer: a cluster randomized cohort study in China","volume":"109","author":"C Guan","year":"2018","journal-title":"Cancer Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e877","DOI":"10.1016\/S2468-2667(21)00157-2","article-title":"Disparities in stage at diagnosis for five common cancers in China: a multicentre, hospital-based, observational study","volume":"6","author":"H 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high-risk individuals: a population-based, multicenter prospective study in China","volume":"13","author":"H Liu","year":"2024","journal-title":"Cancer Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1200\/JCO.23.01284","article-title":"Effectiveness of endoscopic screening on esophageal cancer incidence and mortality: a 9-year report of the endoscopic screening for esophageal cancer in China (ESECC) randomized trial","volume":"42","author":"M Liu","year":"2024","journal-title":"J Clin Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/gutjnl-2019-320200","article-title":"Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study","volume":"70","author":"R Chen","year":"2021","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1200\/JCO.2014.58.0423","article-title":"Long-term follow-up of a community assignment, one-time endoscopic screening study of esophageal cancer in China","volume":"33","author":"W Wei","year":"2015","journal-title":"J Clin Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4511","DOI":"10.1002\/cncr.33119","article-title":"Long-term effectiveness of one-time endoscopic screening for esophageal cancer: a community-based study in rural China","volume":"126","author":"N Zhang","year":"2020","journal-title":"Cancer"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3376","DOI":"10.1200\/JCO.24.00557","article-title":"Reduction in esophageal cancer incidence and mortality by screening endoscopy","volume":"42","author":"C Xia","year":"2024","journal-title":"J Clin 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