{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:10:07Z","timestamp":1752232207456,"version":"3.41.2"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"name":"The science and technology project of Xuzhou City","award":["KC23280"],"award-info":[{"award-number":["KC23280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from Angelica sinensis, may offer a potential alternative therapeutic approach for UC through the downregulation of inflammatory mediators. Nonetheless, the pharmacological impacts and molecular pathways of angelicone in UC management, particularly in relation to gut microbiota, remain unexplored. The current study scrutinized the modifications in gut microbiota in mice afflicted with UC, induced by 3% dextran sodium sulfate (DSS), utilizing 16S rRNA sequencing. The study demonstrated that angelicone substantially enhanced clinical indices, mitigated colonic damage, decreased cytokine levels, and reestablished the integrity of the intestinal epithelial barrier in UC mice. Furthermore, we discerned distinct bacterial genera that were responsive to angelicone treatment. Importantly, angelicone\n          augmented the abundance of gut microbiota and partially reinstated the disrupted intestinal microbial composition, inclusive of the phyla Proteobacteria, Firmicutes, and Bacteroidetes. To summarize, our research offers novel perspectives into the intervention mechanisms of angelicone in the treatment of UC.<\/jats:p>","DOI":"10.1055\/a-2565-6197","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T20:13:32Z","timestamp":1742847212000},"page":"430-439","source":"Crossref","is-referenced-by-count":0,"title":["Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota"],"prefix":"10.1055","volume":"91","author":[{"given":"Chengwei","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Anal-Rectal, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 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