{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:59:10Z","timestamp":1791259150941,"version":"4.1.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Low-dose aspirin is an established preventive strategy for reducing the risk of preeclampsia in patients with designated risk factors.<\/jats:p>\n                  <jats:p>This prospective observational study evaluated trends in aspirin prescription rates in a multihospital health system over a 10-month period during which a policy to offer low-dose aspirin universally was instituted.<\/jats:p>\n                  <jats:p>A total of 11,382 patients were included and an interrupted time series was used to analyze rates of aspirin prescriptions ordered by 16 weeks, before and after implementation of the universal policy. There were statistically significant increases in aspirin prescription rates for the entire cohort (incidence rate ratio [IRR]: 2.93; 95% confidence interval [CI]: 2.13\u20134.04) and for a high-risk subcohort including patients with chronic hypertension, pregestational diabetes, and\/or multiple gestation (IRR: 1.48; 95% CI: 1.26\u20131.76).<\/jats:p>\n                  <jats:p>Instituting a policy to offer universal low dose aspirin during pregnancy resulted in significantly increased utilization among patients with high-risk indications for aspirin.<\/jats:p>","DOI":"10.1055\/a-2565-9272","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T22:37:16Z","timestamp":1742942236000},"page":"272-274","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Universalizing Aspirin Prophylaxis on Treatment Provision for High-Risk Pregnant Patients"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7932-1987","authenticated-orcid":false,"given":"Adina R.","family":"Kern-Goldberger","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"},{"name":"Department of Quantitative Health Sciences, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirat","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara D.","family":"Dolin","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bajan","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Raiff","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Lappen","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Obstetrics, Gynecology, and Women's Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"9575","key":"ref1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"L M Askie","year":"2007","journal-title":"Lancet"},{"issue":"02","key":"ref2","first-page":"CD004659","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","author":"L Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"D L Rolnik","year":"2017","journal-title":"N Engl J 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Gynecol"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/jama.2018.21367","article-title":"Ocular prophylaxis for gonococcal ophthalmia neonatorum: US preventive services task force reaffirmation recommendation statement","volume":"321","author":"S J Curry","year":"2019","journal-title":"JAMA"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.2023.12876","article-title":"Folic acid supplementation to prevent neural tube defects: US preventive services task force reaffirmation recommendation statement","volume":"330","author":"M J Barry","year":"2023","journal-title":"JAMA"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/AOG.0000000000001115","article-title":"A cost-benefit analysis of low-dose aspirin prophylaxis for the prevention of preeclampsia in the United States","volume":"126","author":"E F Werner","year":"2015","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of 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