{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:11:28Z","timestamp":1777180288803,"version":"3.51.4"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our current research aims to investigate how Resveratrol influences\n                        DOX-induced apoptosis in Saos-2 cells resulting from DNA damage.<\/jats:p><jats:p>Saos-2 cells were cultured with DOX, and an MTT assay was conducted to\n                        evaluate cell viability. The expression levels of DNA damage markers were\n                        evaluated using qRT-PCR and western blotting methods. Apoptosis was also\n                        investigated by flow cytometry.<\/jats:p><jats:p>In a dose-dependent way, DOX produced a profuse suppression of cell\n                        proliferation. This study investigates the effect of Resveratrol on\n                        DOX-induced apoptosis due to DNA damage in Saos-2 cells (P&lt;0.05).\n                        There was an increase in H2AX, ATR, ATM, Rad51, and p53 expression, possibly\n                        contributing to subsequent apoptosis. Furthermore, Resv enhanced the\n                        apoptosis caused by DOX in Saos-2 cells.<\/jats:p><jats:p>The findings from the current research provide an understanding of how Resv\n                        plays a role in potentially treating osteosarcoma by enhancing DOX-induced\n                        apoptosis.<\/jats:p>","DOI":"10.1055\/a-2567-9916","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:47:33Z","timestamp":1745534853000},"page":"202-208","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Doxorubicin Sensitivity in Osteosarcoma Cancer Cells:\n                    Unveiling the Role of Resveratrol-Induced Oxidative DNA Damage"],"prefix":"10.1055","volume":"75","author":[{"given":"Mohammad Reza","family":"Bazavar","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, School of Medicine and Shohada\n                    Educational Hospital, Tabriz University of Medical Sciences, Tabriz,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Helali","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, School of Medicine and Shohada\n                    Educational Hospital, Tabriz University of Medical Sciences, Tabriz,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Mohammadzadeh","family":"Boukani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences,\n                    Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1527","authenticated-orcid":false,"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences,\n                    Tabriz, Iran"},{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of\n                    Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-8118","authenticated-orcid":false,"given":"Amir","family":"Valizadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences,\n                    Tabriz, Iran"},{"name":"Department of Clinical Biochemistry and Laboratory Medicine, Faculty of\n                    Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41571-021-00519-8","article-title":"Advancing therapy for osteosarcoma","volume":"18","author":"J Gill","year":"2021","journal-title":"Nat Rev Clin 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Interact"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of Multidrug Resistance in Cancer Chemotherapy","volume":"21","author":"K Bukowski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.7150\/thno.57828","article-title":"Recent progress in nanomedicine for enhanced cancer chemotherapy","volume":"11","author":"G Wei","year":"2021","journal-title":"Theranostics."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","article-title":"Cisplatin and beyond: molecular mechanisms of action and drug resistance\n                    development in cancer chemotherapy","volume":"53","author":"T Makovec","year":"2019","journal-title":"Radiol Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00262-021-03013-3","article-title":"Chemotherapy: a double-edged sword in cancer 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Medicine"},{"key":"ref13","first-page":"12","article-title":"Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial\n                    Functions","author":"L Kursvietiene","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"ref14","first-page":"4","article-title":"Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor\n                    Microenvironment and Malignant Behaviors of Cancer","volume":"20","author":"Y Han","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref15","first-page":"12","article-title":"The Role of Resveratrol in Cancer Therapy","volume":"18","author":"J H Ko","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"113274","DOI":"10.1016\/j.biopha.2022.113274","article-title":"Applications of resveratrol in the treatment of gastrointestinal cancer","volume":"153","author":"M Roshani","year":"2022","journal-title":"Biomed 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Drug-Resistant Cancer Cells","volume":"14","author":"C Y Choi","year":"2022","journal-title":"Nutrients"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1749-6632.2010.05852.x","article-title":"Chemosensitization of tumors by resveratrol","volume":"1215","author":"S C Gupta","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.20517\/cdr.2021.148","article-title":"DNA damage and metabolic mechanisms of cancer drug resistance","volume":"5","author":"D Tiek","year":"2022","journal-title":"Cancer Drug Resist"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbagen.2013.10.023","article-title":"Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant\n                    human breast cancer cells via increased cellular influx of doxorubicin","volume":"1840","author":"T H Kim","year":"2014","journal-title":"Biochim Biophys 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